Brain stroke validation from diffusion weighed image of twice-refocused spin-echo sequence
| Project/Area Number |
24591801
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | 秋田県立脳血管研究センター(研究部門) |
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Principal Investigator |
Nakamura Kazuhiro 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 主任研究員 (10312638)
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| Co-Investigator(Kenkyū-buntansha) |
豊嶋 英仁 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 特任研究員 (00595077)
木下 俊文 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 放射線医学研究部長 (70314599)
近藤 靖 秋田県立脳血管研究センター(研究部門), 神経内科学研究部, 特任研究員 (70360360)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 脳・神経 / 放射線 / 核磁気共鳴画像 / 拡散強調画像 / 脳卒中 / 核磁気共鳴画像（MRI) / 核磁気共鳴画像（ＭＲＩ） / 核磁気共鳴画像(MRI) |
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| Outline of Final Research Achievements |
Typical single refocused pulsed-gradient spin-echo (SRSE-DWI) sequence is interacted by susceptibility-induced background gradient fields around vessels, while twice-refocused spin-echo (TRSE-DWI) sequence is reduced the effect. The difference between SRSE-DWI and TRSE-DWI will indicate CBV weighted image. We evaluated the ADC reduced ratio in both sequence with computer simulations in a vascular model. We made TRSE-DWI sequence for animal MRI and evaluated on stroke model rats. The simulation results indicate possible criteria for brain stroke validation. The experimental results did not show adequate S/N images. At this moment, we now evaluating the images from normal volunteer and stroke patients.
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Report
(6 results)
Research Products
(27 results)
