| Project/Area Number |
24591805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kinki University (2013-2014)
National Institute of Radiological Sciences (2012) |
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Principal Investigator |
KIMURA Yuichi 近畿大学, 生物理工学部, 教授 (60205002)
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| Co-Investigator(Kenkyū-buntansha) |
TOYAMA Hiroshi 藤田保健衛生大学, 医学部, 教授 (90247643)
HONTANI Hidekata 名古屋工業大学, 情報工学部, 教授 (60282688)
HATANO Kentaro 国立長寿医療研究センター, 認知症先進医療開発センター, 室長 (50228475)
YAMADA Takashi 中部大学, 応用生物学部, 講師 (50532860)
山田 貴史 中部大学, 公私立大学の部局等, 講師 (50531860)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子イメージング / PET / 核医学 / 動物実験 / Bayes推定 / 生体信号処理 |
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| Outline of Final Research Achievements |
This project aimed at developing methods for blood sampling, metabolite analysis, and noise deduction for quantitative functional molecular imaging using PET and mice. The blood sampling system can be operated automatically, and it can separate the plasma and measure the volume and an amount of radioactivity using a few micro-litter of sampled blood that does not affect mice physiological condition. Direct metabolite analysis is also archived with the sampling system. And, a statistical model for noise in measured data can reduce the noise. These achievements can be applied mice to fully quantitative PET functional imaging to mice.
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