| Project/Area Number |
24591806
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Clinical research Center, Chiba-East National Hospital, National Hospital Organization |
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Principal Investigator |
otuki kazunori 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (50399755)
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| Co-Investigator(Kenkyū-buntansha) |
AKUTSU naotake (ITO taihei / KENMOCHI takashi / MARUTAMA michihiro) 千葉東病院臨床研究センター, 移植医療再生部長 (00344979)
丸山 通広 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (40399754)
剣持 敬 藤田保健衛生大学, 医学部, 教授 (50215133)
伊藤 泰平 藤田保健衛生大学, 医学部, 准教授 (60509701)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | pet / PET / 移植・再生医療 / 膵臓移植 / 核医学 / ＰＥＴ / 膵臓再生 / Computed Tomography / ドナー / メチオニン |
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| Outline of Final Research Achievements |
The objective of this study was to evaluate the post-operative insulin independence in 10 living donor (LD) and 10 brain-dead donor (BD) pancreas transplantations for 20 patients with type I diabetes mellitus by using 11C-methionine PET. Patient survivals were 100% at 5 years for LD transplants and at 2 years for BD transplants. The SUVs of LD and BD pancreas transplants with insulin independence were 7.2 ± 1.8 and 10.4 ± 2.3, respectively. The SUVs of LD pancreas transplants with insulin dependence and BD pancreas transplants with graft failure were 3.6 ± 1.1 and 2.9 ± 1.0, respectively. At 5 years after transplantation, for the LD transplants, the insulin-independent rate was 100% for the graft recipients with an SUV higher than 5, and the median insulin independence duration of the graft recipients with an SUV lower than 5 was 7 month (p < 0.01). The 11C-methionine PET may be a potent modality to predict long-term insulin independence and the avoidance of pancreas graft failure.
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