Development of a new catheter for segmental adrenal venous sampling

• Project/Area Number: 24591808
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: Seiji Kazumasa 東北大学, 大学病院, 講師 (50400247)
• Co-Investigator(Kenkyū-buntansha): Takase Kei 東北大学, 医学系研究科, 教授 (60361094) ; Morimoto Rei 東北大学, 大学病院, 助教 (30547394)
• Co-Investigator(Renkei-kenkyūsha): Oota Makoto 東北大学, 流体科学研究所, 准教授 (20400418) ; Haga Yoichi 東北大学, 医工学(系)研究科(研究院), 教授 (00282096) ; Nakamura Yasuhiro 東北大学, 医学系研究科, 准教授 (80396499)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: インターベンショナルラジオロジー / 血管 / 放射線 / 副腎 / 副腎静脈サンプリング / 原発性アルドステロン症 / カテーテル / 原発性アルドステロン

Outline of Final Research Achievements

Segmental venous sampling is essential for diagnosis and localization of aldosterone producing adenomas. In segmental adrenal venous sampling (S-AVS), blood samples are obtained with microcatheters inserted into the target venous tributary. However, it sometimes happen that blood samples cannot be obtained through catheters. In such cases, it is assumed that suction pressure　deforms venous wall, then catheter tip is considered to be occluded. To our knowledge, there has been no study concerning hemodynamics in venous catheter blood sampling. The purpose of this study is to simulate the blood flow in venous blood sampling using synthetic very small blood vessel or Computational Fluid Dynamics method and to search the catheter tip shape suitable for the procedure.
The prototype of microcatheter whose tip was shaped suitable for S-AVS was created. And then, the performance of the microcatheter was evaluated in an animal study.

Research Products

• [Presentation] Development of a new catheter for selective venous sampling: a new study with improved model (2016)
  • Author(s): 木下 知、清治和将、太田 信、高瀬 圭
  • Organizer: ECR 2016
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2016-03-02
• [Presentation] Development of a New Catheter with Innovative Concepts for Selective Ven ous Sampling- Preliminary CFD Study (2015)
  • Author(s): 木下 知、清治和将、高瀬 圭、太田 信
  • Organizer: 12th ICFD(International Conference on Flow Dynamics）
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2015-10-27
• [Presentation] Development of a new catheter for selective venous sampling: a primary C FD study (2015)
  • Author(s): 木下 知、清治和将、高瀬 圭、松本 翔、太田 信
  • Organizer: ECR(European congress of radiology)2015
  • Place of Presentation: オーストリア、ウィーン
  • Year and Date: 2015-03-04 – 2015-03-08
• [Presentation] Development of a new catheter for selective venous sampling (2014)
  • Author(s): 木下 知、清治和将、高瀬 圭、松本 翔、太田 信
  • Organizer: COMSOL Conference Tokyo 2014
  • Place of Presentation: 東京 秋葉原
  • Year and Date: 2014-12-05
• [Presentation] Development of a new catheter with innovative concept for selective venous sampling - preliminary study (2013)
  • Author(s): 木下 知、清治和将、大竹 匡、太田 信、権 貴龍
  • Organizer: 10th ICFD (International Conference of Flow Dynamics)
  • Place of Presentation: 仙台国際センター