Development of novel tumor-specific PLGA microbubble ultrasound contrast media
| Project/Area Number |
24591809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
TSUSHIMA Yoshito 群馬大学, 医学(系)研究科(研究院), 教授 (20375546)
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| Research Collaborator |
ACHMAD Arifudin 群馬大学, 大学院医学系研究科放射線診断核医学分野, 助教 (30757381)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 超音波断層法 / 超音波造影剤 / マイクロバブル / 抗EGFR抗体 / Cetuximab / drug-delivery agent / ナノバブル |
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| Outline of Final Research Achievements |
The aim of this study was to develop a novel ultrasound contrast media which specifically accumulates into malignant tumors, and also acts as a drug-delivery agent. After several attempts, Cetuximab-labelled nanobubble (CTX-NB) was successfully synthesized. Cetuximab is the monoclonal antibody to the epidermal growth factor receptor (EFGR). CTX-NB has a shell of Poly-D,L-lactide-co-glycolide (PLGA), and contains perfluorooctyl bromide (PFOB). Specific accumulation and internalization of CTX-NB were microscopically confirmed in vitro using cultured EFGR-positive MDA-MB-231 human breast cancer cells.
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Report
(4 results)
Research Products
(5 results)
