Significance of gadoxetic acid-enhanced MR imaging signal intensity for predicting the efficacy of hepatic arterial infusion chemotherapy in hepatocellular carcinoma

• Project/Area Number: 24591814
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: FUJITA Nobuhiro 九州大学, 大学病院, 助教 (30610612)
• Co-Investigator(Kenkyū-buntansha): NISHIE Akihiro 九州大学, 医学(系)研究科(研究院), 講師 (20457427) ; ASAYAMA Yoshiki 九州大学, 大学病院, 講師 (40380414) ; USHIJIMA Yasuhiro 九州大学, 医学(系)研究科(研究院), 助教 (40432934) ; TAKAYAMA Yukihisa 九州大学, 医学(系)研究科(研究院), 助教 (60546563) ; HONDA Hiroshi 九州大学, 医学(系)研究科(研究院), 教授 (90145433) ; 石神 康生 九州大学, 大学病院, 助教 (10403916)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 肝細胞癌 / MRI / Gd-EOB-DTPA / 肝動注化学療法 / 放射線医薬品・造影剤 / 放射性医薬品・造影剤

Outline of Final Research Achievements

The purpose of the present study was to clarify the relationship in hepatocellular carcinoma cases between the tumor signal intensity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging and the patient response to hepatic arterial infusion chemotherapy. The higher intensity group in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging showed a significantly higher progression-free survival rate than the lower intensity group. Patients with HCCs of higher intensity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging can respond better to hepatic arterial infusion chemotherapy.

Research Products

• [Journal Article] Hepatocellular carcinoma: clinical significance of signal heterogeneity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging. (2015)
  • Author(s): Fujita N, Nishie A, Kubo Y, Asayama Y, Ushijima Y, Takayama Y, Moirta K, Shirabe K, Aishima S, Honda H.
  • Journal Title: European Radiology Volume: 25 Issue: 1 Pages: 221-220
  • DOI: 10.1007/s00330-014-3349-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Role of tumor-associated macrophages in the angiogenesis of well-differentiated hepatocellular carcinoma: pathological-radiological correlation. (2014)
  • Author(s): Fujita N, Nishie A, Aishima S, Kubo Y, Asayama Y, Ishigami K, Kakihara D, Ushijima Y, Takayama Y, Shirabe K, Oda Y, Honda H.
  • Journal Title: ONCOLOGY REPORTS Volume: 31 Issue: 6 Pages: 2499-2505
  • DOI: 10.3892/or.2014.3138
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Significance of gadoxetic acid-enhanced MR imaging signal intensity for predicting the efficacy of hepatic arterial infusion chemotherapy in hepatocellular carcinoma (2015)
  • Author(s): Fujita N, Nishie A, Asayama Y, Ishigami K, Ushijima Y, Takayama Y, Okamoto D, Morita K, Shirabe K, Koto K, Kubo Y, Aishima S, Honda H.
  • Organizer: 27th European Congress of Radiology
  • Place of Presentation: VIENNA
  • Year and Date: 2015-03-04 – 2015-03-08
• [Presentation] 肝細胞癌のGd-EOB-DTPA造影MRI所見と持続肝動注化学療法の効果の比較検討 (2014)
  • Author(s): 藤田展宏、西江昭弘、浅山良樹、牛島泰宏、高山幸久、岡本大佑、森田孝一郎、調 憲、古藤 和浩、久保雄一郎、相島慎一、本田浩
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] Clinical significance of signal heterogeneity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging in hepatocellular carcinoma (2013)
  • Author(s): Nobuhiro Fujita, Akihiro Nishie, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Hiroshi Honda, Dai Shimamoto, Koichiro Morita, Ken Shirabe, Yuichiro Kubo
  • Organizer: 99th Scientific Assembly and Annual Meeting of Radiological Society of North America
  • Place of Presentation: Chicago
• [Presentation] 肝細胞癌のGd-EOB-DTPA造影MRI所見と悪性度の検討 -肝細胞相における取り込みの不均一性の意義- (2013)
  • Author(s): 藤田展宏、西江昭弘、浅山良樹、牛島泰宏、高山幸久、調 憲、 相島慎一、本田浩
  • Organizer: 第19回肝血流動態イメージ研究会
  • Place of Presentation: 東京