Treatment of venous thromboembolism with molecular targeting

• Project/Area Number: 24591816
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Miyazaki
• Principal Investigator: FURUKOJI Eiji 宮崎大学, 医学部, 助教 (00423723)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 静脈 / 血栓 / 遺伝子 / 静脈血栓 / 遺伝子導入

Outline of Final Research Achievements

The purpose of this study is to examine the effects of the gene transfer after thrombolysis in rat inferior vena cava (IVC). We exposed rat IVC and venous thrombosis was induced by ligation of the IVC. After thrombolysis, we performed gene transfer using recombinant adenovirus. As a result, it was expected that we could evaluate the association between thrombolysis and gene transfer in this animal model.