Development of novel interventional therapy for advanced pancreatic cancer

• Project/Area Number: 24591819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nara Medical University
• Principal Investigator: TANAKA Toshihiro 奈良県立医科大学, 医学部, 准教授 (70326338)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 膵癌 / 血管塞栓術 / 球状塞栓物質 / 薬剤溶出性ビーズ / インターベンショナル・ラジオロジー / IVR

Outline of Final Research Achievements

To develop novel interventional therapy for liver metastases from pancreatic cancer. First, in ex vivo study, feasibility of bead-TAE using arterial port system was examined. Beads under 500um in size could pass through the port. Next, for hypovascular liver metastases, bland-TAE using beads was conducted, and high anti-tumor effect was shown. In a study of irinotecan eluting beads, using VX2 tumor rabbits, 40um beads TACE was conducted and histologically beads were distributed inside of the tumors with high necrotic ratio and also pharmacological advantage was shown.

Research Products

• [Journal Article] Pharmacokinetics and AntitumorEfficacyof Chemoembolization Using40 lm Irinotecan-Loaded Microspheres inaRabbitLiverTumorModel (2014)
  • Author(s): Tanaka T, Nishiofuku H, Fukuoka Y 他
  • Journal Title: J Vasc Intervent Radiol Volume: 25 Issue: 7 Pages: 1037-1044
  • DOI: 10.1016/j.jvir.2014.04.005
  • Peer Reviewed
• [Journal Article] An early-stage, non-hypervascular HCC successfully treated by superselective, bland transarterial embolization using 40-μm microspheres (2014)
  • Author(s): Tanaka T, Maeda S, Nishiofuku H, Masada T, Sato T, Anai H, Sakaguchi H, Kichikawa K
  • Journal Title: Anticancer Res Volume: 34 Pages: 1947-1951
  • Peer Reviewed
• [Journal Article] Repeated bland-TAE using small microspheres injected via an implantable port-catheter system for liver metastases: an initial experience (2014)
  • Author(s): Tanaka T, Nishiofuku H, Maeda S, Masada T, Anai H, Sakaguchi H, Kichikawa K
  • Journal Title: Cardiovasc Intervent Radiol Volume: 37 Pages: 493-497
  • Peer Reviewed