Development of nuclear medicinal molecular imaging probe using nanocarrier "Lactosome"
| Project/Area Number |
24591821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Shunsaku 京都大学, 工学研究科, 教授 (80150324)
KURIHARA Kensuke 京都大学, 医学研究科, 助教 (90531997)
FUNAKI Yoshihito 東北大学, サイクロトロン・アイソトープセンター, 助教 (50261491)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 分子イメージング / 腫瘍 / PET / SPECT / 放射性標識 / ラクトソーム / 放射性標識合成 / マウス / インビボ |
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| Outline of Final Research Achievements |
Nanoparticles in the blood stream with diameters from a few tens of nm to 200 nm are expected to accumulate in solid tumors due to the enhanced permeability and retention (EPR) effect. We focus on and have developed micelles composed of amphiphilic polymer “Lactosome” for cancer imaging probes, as a novel nanocarrier which possesses a tumor accumulation property due to the EPR effect. We reported previously radiosynthesis and a successful in vivo imaging of mouse tumor of 18F-labeled Lactosome as the preliminary study with using small animal PET. In this study, in order to elucidation further characteristics of Lactosomes with aim of developing radiotracers for in vivo solid tumor imaging by SPECT, some kind of radioiodine-labeled Lactosomes were synthesized and evaluated in tumor or inflammation model mice.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Radiosynthesis and initial evaluation of 18F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.2013
Author(s)
F.Yamamoto, R.Yamahara, A.Makino, K.Kurihara, H.Tsukada, E.Hara, I.Hara, S.Kizaka-Kondoh, Y.Ohkubo, E.Ozeki, S.Kimura
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Journal Title
Nucl. Med. Biol.
Volume: 40
Issue: 3
Pages: 387-394
DOI
Related Report
Peer Reviewed
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[Presentation] COX-2イメージングを目的としたニメスリド誘導体の脳移行性評価2015
Author(s)
山本由美, 荒井潤, 比佐拓矢, 岡安明日香, 大 明代, 齋藤陽平, 山本文彦, 向高弘, 大嶋孝志, 前田稔, 大久保恭仁
Organizer
日本薬学会第135年会
Place of Presentation
神戸
Year and Date
2015-03-26 – 2015-03-28
Related Report
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[Presentation] Chemotherapy and Radionuclide Therapy Using 90Y-DOTA-Lactosome after Percutaneous Ethanol Injection Therapy Compared with Using Doxorubicin and Pegylated liposomal doxorubicin2014
Author(s)
Kensuke Kurihara, Motoki Ueda, Isao Hara, Eri Hara, Kohei Sano, Akira Makino, Eiichi Ozeki, Fumihiko Yamamoto, Hideo Saji, Kaori Togashi and Shunsaku Kimura
Organizer
27 th Annual Congress of the European Association of Nuclear Medicine
Place of Presentation
Gothenburg, Sweden
Year and Date
2014-10-18 – 2014-10-22
Related Report
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