| Project/Area Number |
24591824
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
IIDA YASUHIKO 鈴鹿医療科学大学, 薬学部, 教授 (60252425)
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| Research Collaborator |
FUJISAWA YUTAKA 鈴鹿医療科学大学, 薬学部, 助手 (30511993)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | PET診断 / がん診断 / ヘマトポルフィリン / 放射性薬剤 / Cu-64 / PET |
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| Outline of Final Research Achievements |
For positron emission tomography (PET) diagnosis, we usually use four β+ emitters, 11C, 13N, 15O, and 18F. However, these radionuclides cannot allow us to take enough time of radiopharmaceuticals synthesis, preparation or delivering due to their short half-lives from 2 to 110 minutes. Therefore, the development of novel PET tracers with longer half-lives would be contributed to releasing from such time restrictions and enlarging PET utilities. 64Cu is a β+ emitter with long half-life (12.8hr) and it has a suitable property for labeling of various PET tracers. In this study, we planned to develop novel PET tracers labeled with 64Cu using for tumor diagnosis, and synthesized 64Cu labeled Hematoporphyrin (HP) and its derivatives (HPDs). Hematoporphyrin has been widely used as photosensitizer in photodynamic therapy and can specifically accumulate in tumors. We evaluated their potentials as PET tracers for tumor diagnosis in mice bearing MDA-MB-231 human breast cancer cells.
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