Development of integrin targeting liposome for imaging and radionuclide therapy of pancreatic cancer
| Project/Area Number |
24591828
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
YOSHIMOTO MITSUYOSHI 独立行政法人国立がん研究センター, その他部局等, 主任研究員 (00345638)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵がん / リポソーム / RGD / インテグリン / 膵癌 / RGDペプチド / 内照射治療 |
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| Outline of Final Research Achievements |
αvβ3 integrin is overexpressed in endothelial cells and various tumor cells including pancreatic cancer. In this study, we developed RGD-modified liposomes for imaging and internal radionuclide therapy of pancreatic cancer. We successfully synthesized the RGD-modified liposomes with about 100 nm of particle size. The RGD-modified liposomes dose-dependently inhibited the binding of 125I-echistatin to PANC-1. The IC50 values were 5-67 μM as phospholipids. In contrast, RKG-modified liposome and unmodified liposome did not inhibit the binding. Biodistribution studies using the liposomes loaded with 111In indicated rapid clearance of the RGD-modified liposome from blood. Significant accumulation of radioactivity in spleen was found with increase in the amount of RGD modification (170.4-403.9% ID/g at 24 h). Unmodified liposome showed the highest tumor uptake (2.80% ID/g) at 24 h, whereas the RGD-modified liposomes showed the lower tumor uptake (1.47-2.25% ID/g).
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Controlled Administration of Penicillamine Reduces Radiation Exposure in Critical Organs during 64Cu-ATSM Internal Radiotherapy: A Novel Strategy for Liver Protection2014
Author(s)
Yoshii Y, Matsumoto H, Yoshimoto M, Furukawa T, Morokoshi Y, Sogawa C, Zhang MR, Wakizaka H, Yoshii H, Fujibayashi Y, Saga T.
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Journal Title
PLoS One
Volume: 9
Issue: 1
Pages: e86996-e86996
DOI
Related Report
Peer Reviewed
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[Journal Article] Non-invasive X-ray Micro-computed Tomographic Evaluation of Indomethacin on Urethane-induced Lung Carcinogenesis in Mice2012
Author(s)
Ueno T, Imaida K, Yoshimoto M, Hayakawa T, Takahashi M, Imai T, Yanaka A, Tsuta K, Komiya M, Wakabayashi K, Mutoh M.
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Journal Title
Anticancer Resarch
Volume: 32
Pages: 1773-4780
Related Report
Peer Reviewed
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[Presentation] Controlled administration of penicillamine reduces radiation exposure to normal organs in 64Cu-ATSM internal radiotherapy2013
Author(s)
Yoshshii Y, Matsumoto H, Yoshimoto M, Furukawa T, Yukie M, Sogawa C, Zhang M, Wakizaka H, Fujibayashi Y, Saga T.
Organizer
The 60th Annual Meeting of the Society of Nuclear Medicine
Place of Presentation
Vancouver, Canada
Related Report
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