Approaches to the 4D-CBCT using 2 axis fluoroscopic X-ray

• Project/Area Number: 24591829
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: SHIMIZU Shinichi 北海道大学, 医学(系)研究科(研究院), 准教授 (50463724)
• Co-Investigator(Kenkyū-buntansha): MIYAMOTO Naoki 北海道大学, 北海道大学病院, 助教 (00552879) ; TAKAO Seishin 北海道大学, 北海道大学病院, 助教 (10614216)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 放射線治療 / 粒子線治療 / 陽子線治療 / 動体追跡装置 / CBCT / 4次元 / 4D-CBCT / コーンビームCT / 4DCT / 四次元放射線治療

Outline of Final Research Achievements

Construction of a radiation therapy system which can consider respiratory movement of tumor and organs. Location variation and irradiation time are also considered using the 2 axis of X-ray fluoroscopic motion tracking device that are installed at the proton therapy within the gantry. To enable image of the cone-beam CT to get the original source image of 4-dimensional CBCT (4D-CBCT) with the use of the motion tracking device and try to develop the principle and performs imaging test by phantom. Morphological changes of the patients on the treatment couch by imaging moving tumors and organs by 4D-CBCT, the appropriateness of the treatment planning time and compare present status of tumor irradiated and the condition of the normal tissues are to be verified.

Research Products

• [Journal Article] Early results of urethral dose reduction and small safety margin in intensity-modulated radiation therapy (IMRT) for localized prostate cancer using a real-time tumor-tracking radiotherapy (RTRT) system (2014)
  • Author(s): Shimizu S, Nishioka K, Suzuki R, Shinohara N, Maruyama S, Abe T, Kinoshita R, Katoh N, Onimaru R, Shirato H
  • Journal Title: Radiation Oncology Volume: 9 Issue: 1 Pages: 118-126
  • DOI: 10.1186/1748-717x-9-118
  • NAID: 120005438247
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preliminary analysis for integration of spot-scanning proton beam therapy and real-time imaging and gating. (2014)
  • Author(s): Shimizu S, Matsuura T, Umezawa M, Hiramoto K, Miyamoto N, Umegaki K, Shirato H
  • Journal Title: Physica Medica Volume: 30 Issue: 5 Pages: 555-558
  • DOI: 10.1016/j.ejmp.2014.04.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A proton beam therapy system dedicated to spot-scanning increases accuracy with moving tumors by real-time imaging and gating and reduces equipment size. (2014)
  • Author(s): Shimizu S, Miyamoto N, Matsuura T, Fujii Y, Umezawa M, Umegaki K, Hiramoto K, Shirato H
  • Journal Title: PLoS One Volume: 9(4) Issue: 4 Pages: 94971-94977
  • DOI: 10.1371/journal.pone.0094971
  • NAID: 120005438246
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT (2013)
  • Author(s): Nishioka K, Shimizu S, Kinoshita R, Inoue T, Onodera S, Yasuda K, Harada K, Nishikawa Y, Onimaru R, Shirato H
  • Journal Title: Radiation Oncology Volume: 8 Issue: 1 Pages: 185-185
  • DOI: 10.1186/1748-717x-8-185
  • NAID: 120005372345
  • Peer Reviewed
• [Presentation] Realization of the Cone Beam CT by FPDs That Mounted on the Spot-Scanning Dedicated Proton Beam Gantry (2014)
  • Author(s): Shimizu S, Takao S, Matsuura T, Miyamoto N, Baba R, Umekawa T, Matsuda K, Sasaki T, Nagamine Y, Umegaki K, Shirato H
  • Organizer: ASTRO 56th Annual meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Safety, stability, and location of implantation of multiple gold markers into the soft bladder wall by rigid cystoscopy (2013)
  • Author(s): Nishioka K, Shimizu S, Onimaru R, Kinoshita R, Kato N, Harada K, Abe T, Maruyama S, Shinohara N, Shirato H
  • Organizer: 55th annual meeting of American Society of Therapeutic Radiology and Oncology
  • Place of Presentation: Georgia World Congress Center(Atlanta,USA)
• [Presentation] 4DCTを用いた肺内マーカー移動の解析 (2013)
  • Author(s): 加藤徳雄、井上哲也、鈴木隆介、原田慶一、鬼丸力也、清水伸一、白土博樹
  • Organizer: 日本医学放射線学会北日本地方会
  • Place of Presentation: 新潟コンベンションセンター(新潟市)
• [Presentation] Real-time tracking radiotherapy (2013)
  • Author(s): Shimizu S
  • Organizer: Particle Radiosurgery, A new Frontier in Physics in Medicine
  • Place of Presentation: conference center of the University of Innsbruck(Obergurgl, Austria)
  • Invited
• [Presentation] Pros and Cons of fluoroscopy based motion detection (2013)
  • Author(s): Shimizu S
  • Organizer: 4D treatment planning workshop 2013
  • Place of Presentation: Paul Scherrer Institute(Villigen, Switzerland)
  • Invited
• [Presentation] 骨盤部CBCT画像での臓器輪郭描出に関する検討． (2012)
  • Author(s): 西岡健太郎、井上哲也、小野寺俊輔、安田耕一、原田慶一、清水伸一、木下留美子、西川由記子、鬼丸力也、白土博樹
  • Organizer: 日本医学放射線学会北日本地方会
  • Place of Presentation: 北海道大学学術交流会館(札幌市)
• [Presentation] Decreasing Acute and Late Toxicity using Urethral Dose Reduction and Smaller Safety Margin around CTV for Prostate Cancer IMRT with a Real-Time Tumor-Tracking (RTRT) System (2012)
  • Author(s): Shimizu S, Nishioka K, Onimaru R, Kinoshita R, Harada K, Nishikawa N, Abe T, Maruyama S, Shinohara N, Shirato H
  • Organizer: 54th annual meeting of American Society of Therapeutic Radiology and Oncology
  • Place of Presentation: Boston Convention and Exhibition Center (USA)
• [Patent(Industrial Property Rights)] 放射線治療システム (2014)
  • Inventor(s): 清水 伸一、髙尾 聖心、宮本 直樹、松浦 妙子、梅垣 菊男、他
  • Industrial Property Rights Holder: 清水 伸一、髙尾 聖心、宮本 直樹、松浦 妙子、梅垣 菊男、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-08-04
  • Overseas
• [Patent(Industrial Property Rights)] 放射線治療システム (2014)
  • Inventor(s): 清水 伸一、髙尾 聖心、宮本 直樹、松浦 妙子、梅垣 菊男、他
  • Industrial Property Rights Holder: 清水 伸一、髙尾 聖心、宮本 直樹、松浦 妙子、梅垣 菊男、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-08-05
  • Overseas
• [Patent(Industrial Property Rights)] 放射線治療システム (2014)
  • Inventor(s): 清水 伸一、髙尾 聖心、宮本 直樹、松浦 妙子、梅垣 菊男、他
  • Industrial Property Rights Holder: 清水 伸一、髙尾 聖心、宮本 直樹、松浦 妙子、梅垣 菊男、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-07-31
  • Overseas
• [Patent(Industrial Property Rights)] 放射線治療システム (2013)
  • Inventor(s): 清水伸一、高尾聖心、宮本直樹、松浦妙子、梅垣菊男、梅川徹、他
  • Industrial Property Rights Holder: 清水伸一、高尾聖心、宮本直樹、松浦妙子、梅垣菊男、梅川徹、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-05