The development of entirely new method for predicting tumor control in radiation therapy using dual-energy spectral CT
| Project/Area Number |
24591830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hirosaki University |
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Principal Investigator |
AOKI Masahiko 弘前大学, 医学部附属病院, 准教授 (70292141)
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| Co-Investigator(Kenkyū-buntansha) |
HATAYAMA Yoshiomi 弘前大学, 大学院医学研究科, 助教 (20451487)
NARITA Yuichiro 弘前大学, 大学院医学研究科, 講師 (30311385)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAI Yoshihiro 弘前大学, 大学院医学研究科, 教授 (50107653)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 放射線治療 / 放射線抵抗性 / 低酸素 / デュアルエネルギーCT / 肺腫瘍 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate an efficacy and limitations of dual energy CT, which became possible for the first time by dual energy CT using a garnet detector, for predicting tumor recurrence after radiotherapy.
As a result, we found following three major findings. First, the material differentiation and material identification and quantification by dual energy CT was accurate. Second, the average iodine density was reduced significantly in large tumors. Finnaly, in tumors that iodine density was reduced, regardless of the tumor size, local recurrence after radiation therapy was significantly higher. The average iodine density estimated by dual energy gemstone spectral CT imaging might be a useful, non-invasive and quantitative assessment of the radioresistance caused by the hypoxic cell population in the tumor.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] LW6, a HIF-1 Inhibitor, Selectively Induces Apoptosis in Hypoxic Cells through Depolarization of Mitochondria in A549 Human Lung Cancer Cells2015
Author(s)
Sato M, Hirose K, Kashiwakura I, Aoki M, Kawaguchi H, Hatayama Y, Akimoto H, Narita Y, Takai Y
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Journal Title
Molecular Medicine Reports
Volume: In press
Related Report
Peer Reviewed / Open Access
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[Journal Article] Investigation of the clinicopathological features of squamous cell carcinoma of the vulva: a retrospective survey of the Tohoku Gynecologic Cancer Unit2015
Author(s)
Futagami M, Yokoyama Y, Iino K, Aoki M, Shoji T, Sugiyama T, Ariga H, Tokunaga H, Takano T, Watanabe Y, Yaegashi N, Jingu K, Sato N, Terada Y, Anbai A, Ohta T, Kurachi H, Kuroda Y, Nishiyama H, Fujimori K, Watanabe T, Sato H, Tase T, Wada H, Mizunuma H.
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Journal Title
Int J Clin Oncol
Volume: In press
Related Report
Peer Reviewed / Open Access
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[Journal Article] Both radical prostatectomy with neoadjuvant LHRH agonist and estramustine and radiotherapy with neoadjuvant hormonal therapy achieved favorable oncological outcome in high risk prostate cancer: a propensity-score matching analysis2014
Author(s)
Koie T, Ohyama C, Yamamoto H, Imai A, Hatakeyama S, Yoneyama T, Hashimoto Y, Yoneyama T, Tobisawa Y, Aoki M, Takai Y
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Journal Title
World Journal of Surgical Oncology
Volume: 12
Issue: 1
Pages: 134-134
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Contribution of dynamic sentinel lymphoscintigraphy images to the diagnosis of patients with malignant skin neoplasms in the upper and lower extremities.2014
Author(s)
Miura H, Ono S, Shibutani K, Seino H, Tsushima F, Kakehata S, Hirose K, Fujita H, Kakuta A, Aoki M, Hatayama Y, Kawaguchi H, Sato M, Takai Y, Kaneko T, Sawamura D
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Journal Title
Springerplus
Volume: 3
Issue: 1
Pages: 625-625
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Preliminary Results from a Multi-center Prospective Study (JROSG 05-5) on Postoperative Radiotherapy for Patients with High-risk Ductal Carcinoma in situ with Involved Margins or Margin Widths 1 mm or less than.2014
Author(s)
Shikama N, Sekiguchi K, Nakamura N, Sekine H, Nakayama Y, Imanaka K, Akiba T, Aoki M, Hatayama Y, Ogo E, Kagami Y, Kawashima M, Karasawa K
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Journal Title
American Journal of Breast Cancer Research
Volume: 1
Pages: 1-8
Related Report
Peer Reviewed
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[Presentation] Stereotactic Body Radiation Therapy for Patients With Pulmonary Interstitial Change2014
Author(s)
H. Yamashita, H. Onishi, Y. Shioyama, M. Yasuo, T. Kenji, Y. Matsuo, M. Akifumi, M. Haruo, M. Aoki, K. Nihe
Organizer
The 56th Annual meeting of the ASTRO
Place of Presentation
San Francisco, CA, USA
Year and Date
2014-09-14 – 2014-09-17
Related Report
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[Presentation] Stereotactic Body Radiation Therapy for Patients 90 Years or Older With Stage I Non-Small Cell Lung Cancer2014
Author(s)
Y. Shioyama, H. Onishi, Y. Matsumoto, K. Takayama, Y. Matsuo, A. Miyakawa, H. Yamashita, H. Matsushita,M. Aoki, K. Nihei
Organizer
The 56th Annual meeting of the ASTRO
Place of Presentation
San Francisco, CA, USA
Year and Date
2014-09-14 – 2014-09-17
Related Report
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