The study of anti-tumor with anti-metastasis under combination of 4-methylumbelliferone on X-irradiation against cancer cell
Project/Area Number |
24591831
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Hirosaki University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MONZEN Satoru 弘前大学, 大学院保健学研究科, 助教 (20514136)
TERASHIMA Shingo 弘前大学, 大学院保健学研究科, 助教 (00583733)
YOSHINO Hironori 弘前大学, 大学院保健学研究科, 助教 (10583734)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 4-メチルウンベリフェロン / 放射線治療 / 転移 / サイトカイン / 放射線 / 抗癌作用 / 4-メチルウンベリフェロン / 浸潤 / 4-メチルウンベリフェロン |
Outline of Final Research Achievements |
Radiotherapy is generally effective against cancer, however distant metastasis cannot be controlled by radiotherapy alone. Our experiments are studied to develop new radiotherapy combined with 4-Methylumbelliferone (MU) in order to prevent metastasis of cancer cells. On this study, the treatment of radiation combined with MU showed anti-cancer and anti-metastatic effects compared with radiation alone. MU is hoped to apply in a clinical setting as anti-metastatic drug on radiotherapy.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Reconsideration of the Iwasaki-Waggener iterative perturbation method for reconstructing high-energy X-ray spectra.2012
Author(s)
Iwasaki A, Kimura S, Sutoh K, Kamimura K, Sasamori M, Seino M, Komai F, Terashima S, Kubota M, Narita Y, Hosokawa Y, Miyazawa M.
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Journal Title
Radiol Phys Technol.
Volume: 5(2):
Pages: 248-269
Related Report
Peer Reviewed
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