Research for enhancing immunological antitumor effects in radiation therapy
| Project/Area Number |
24591832
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 腫瘍免疫 / 放射線治療 / サイトカイン / 抗腫瘍抗体 / 陽子線治療 / 抗腫瘍免疫 / GM-CSF / TGF-β |
|---|
| Outline of Final Research Achievements |
Five of 10 tested mice malignant melanoama after 40 Gy irradiation were controlled (C-group) and the remaining 5 developed progression (R-group). The level of IFN-γ in the supernatants of 48 hr-cultivated spleen cells obtained 28 days after irradiation in the C-group was 5.4 ± 6.9 pg/ml, but that in the R-group was 0.6 ± 0.6 pg/ml (p<0.05). Similarly, plasma IFN-γ level in the C-group was also higher than that in the R-group.
To assess whether autoimmunity induced by radiotherapy (RT) has beneficial impacts on outcomes for metastatic breast cancer patients, plasma serially corrected before, during, and after RT from 28 patients with metastatic breast cancer were analyzed. Western blot experiments were performed to detect antibody formation to tumor antigens extracted from human breast cancer cell lines. Tumor-specific antibodies were detected in 57% of the patients. The 3-year OS rates of IgG positive (n=16) and negative (n=12) groups were 65.6 % and 22.2 %, respectively.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Proton beam therapy combined with concurrent chemotherapy for esophageal cancer.2015
Author(s)
Ishikawa H, Hashimoto T, Moriwaki T, Hyodo I, Hisakura K, Terashima H, Ohkohchi N, Ohno T, Makishima H, Mizumoto M, Ohnishi K, Okumura T, Sakurai H.
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Journal Title
Anticancer Research
Volume: 35
Pages: 1757-62
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Health-related quality of life after carbon-ion radiotherapy for prostate cancer: A 3-year prospective study.2014
Author(s)
Katoh H, Tsuji H, Ishikawa H, Kamada T, Wakatsuki M, Hirasawa N, Suzuki H, Akakura K, Nakano T, Shimazaki J, Tsujii H.
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Journal Title
Int J Urol.
Volume: 21
Issue: 4
Pages: 370-5
DOI
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Peer Reviewed
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[Presentation] Particle therapy for prostate cancer2014
Author(s)
Ishikawa H, Okumura T, Ohnishi K, Mizumoto M, Fukumitsu N, Aihara T, Murofushi K, Katoh H, Ohno T, Nakano T, Sakurai H
Organizer
Micro, Mini and Nano Dosimetry & International Prostate Cancer Treatment Workshop 2014
Place of Presentation
Port Douglas, Australia
Year and Date
2014-10-20 – 2014-10-25
Related Report
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[Presentation] Proton Beam Therapy combined with Concurrent Chemotherapy for Esophageal Cancer2014
Author(s)
Ishikawa H, Okumura T, Ohno T, Makishima H, Ohnishi K, Mizumoto M, Aihara T, Numajiri H, Hashimoto T, Sakurai H
Organizer
The 56th Annual Meeting of the American Society for Radiation Oncology (ASTRO)
Place of Presentation
San Francisco, USA
Year and Date
2014-09-14 – 2014-09-17
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[Presentation] The impacts of radiation-induced up-regulations of IFN-γ, GM-CSF, and TNF-α on local tumor control of malignant melanoma in vivo.2012
Author(s)
Hitoshi Ishikawa, Yukari Yoshida, Yasuko Muto, Su K. Metcalfe, Mei Zhang, Lurong Zhang, Paul Okunieff, Hideyuki Sakurai, Takashi Nakano
Organizer
Annual Meeting - American Society for Radiation Oncology (ASTRO) 2012
Place of Presentation
ボストン、米国
Related Report
