| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
I investigated about radiation-induced anti-tumor immunity in vitro and in vivo and reported about 1) The tumor antigen–specific T-cell response was induced by chemoradiotherapy in patients with esophageal squamous cell cancer, 2) Stress protein, HMGB1, released after irradiation played important role in the activation of tumor specific anti-tumor immunity, 3) In patients with rectal cancer, hyperthermo-chemo-radiotherapy enhaced the expression of HLA class-I in the tumor cells, and 4) In a mouse model, the immune response plays an important role in local and systemic therapeutic efficacies of radiotherapy, which can be augmented by immune checkpoint blockade (antiCTLA4 antibody etc.).
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