Development of new radiotherapy targeting stem cell of glioblastoma

• Project/Area Number: 24591834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: NODA SHIN-EI 群馬大学, 医学部附属病院, 講師 (60396645)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経膠芽腫 / GRP78 / 放射線腫瘍学 / 放射線生物学 / 癌幹細胞 / 放射線治療 / 神経膠腫幹細胞

Outline of Final Research Achievements

cell cycle, DNA double strand break, intracell-metabolism, mechanism of radioresistance for GRP78 were verified using glioblastoma stem cell knockdowned GRP78 specifically by siRNA.
Radiosensitization of glioblastoma stem cell were measured by GRP78 knockdown in vivo.

Research Products

• [Journal Article] Image Fusion for Radiosurgery, Neurosurgery and Hypofractionated Radiotherapy. (2015)
  • Author(s): Inoue H, Nakajima A, Sato H, Noda SE, Saito J. Suzuki Y
  • Journal Title: Cureus Volume: 7 Pages: 252-252
  • Peer Reviewed / Open Access
• [Journal Article] Topics in Chemotherapy, Molecular-targeted Therapy, and Immunotherapy for Newly-diagnosed Glioblastoma Multiforme. (2015)
  • Author(s): Okonogi N, Shirai K, Oike T, Murata K, Noda SE, Suzuki Y, Nakano N
  • Journal Title: Anticancer research Volume: 35 Pages: 1229-1235
  • Peer Reviewed
• [Journal Article] Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irradiation and can be augmented by ctla-4 blockade in a mouse model. (2014)
  • Author(s): Yoshimoto Y, Suzuki Y, Mimura K, Ando K, Oike T, Sato H, Okonogi N, Maruyama T, Izawa S, Noda SE, Fujii H, Kono K, Nakano T.
  • Journal Title: PLoS One. Volume: 9(3) Issue: 3 Pages: e92572-e92572
  • DOI: 10.1371/journal.pone.0092572
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the radiosensitivities of neurons and glial cells derived from the same rat brain. (2014)
  • Author(s): Kudo S, Suzuki Y, Noda SE, Mizui T, Shirai K, Okamoto M, Maminuma T, Yoshida Y, Shirao T,Nakano T.
  • Journal Title: Exp Ther Med Volume: 8 Pages: 754-758
  • Peer Reviewed / Open Access
• [Journal Article] Dose-Volume Prediction of Radiation-Related Complications after Hypofractionated Conformal Radiotherapy for Brain Metastases in Critical Areas (2014)
  • Author(s): Inoue HK, Sato H, Suzuki Y, Saitoh J, Noda SE, Seto K, Torikai K, Nakano T
  • Journal Title: Cureus Volume: 6
  • DOI: 10.7759/cureus.189
  • Peer Reviewed / Open Access
• [Journal Article] HLA class I expression and its alteration by preoperative hyperthermo-chemoradiotherapy in patients with rectal cancer. (2014)
  • Author(s): Sato H, Suzuki Y, Ide M, Katoh T, Noda SE, Ando K, Oike T, Yoshimoto Y, Okonogi N, Mimura K, Asao T, Kuwano H, Nakano T.
  • Journal Title: PLoS One. Volume: 9(9) Issue: 9 Pages: e108122-e108122
  • DOI: 10.1371/journal.pone.0108122
  • Peer Reviewed / Open Access
• [Journal Article] Can combined intracavitary/interstitial approach be an alternative to interstitial brachytherapy with the Martinez Universal Perineal Interstitial Template (MUPIT) in computed tomography-guided adaptive brachytherapy for bulky and/or irregularly shaped gynecological tumors? (2014)
  • Author(s): Oike T, Ohno T, Noda SE, Kiyohara H, Ando K, Shibuya K, Tamaki T, Takakusagi T,Sato H,Nakano T
  • Journal Title: Radiat Oncol. Volume: 16 Issue: 1 Pages: 222-222
  • DOI: 10.1186/s13014-014-0222-6
  • Peer Reviewed / Open Access
• [Journal Article] Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells. (2014)
  • Author(s): Murata K, Noda SE, Oike T, Takahashi A, Yoshida Y, Suzuki Y, Ohno T, Funayama T, Kobayashi Y, Takahashi T, Nakano T.
  • Journal Title: J Radiat Res. Volume: in press
  • Peer Reviewed
• [Journal Article] Radiotherapy plus concomitant adjuvant temozolomide for glioblastoma: Japanese mono-institutional results. (2013)
  • Author(s): Oike T, Suzuki Y, Sugawara K, Shirai K, Noda SE, Tamaki T, Nagaishi M, Yokoo H, Nakazato Y, Nakano T.
  • Journal Title: PLoS One. Volume: 8(11): Issue: 11 Pages: e78943-e78943
  • DOI: 10.1371/journal.pone.0078943
  • Peer Reviewed
• [Journal Article] Five-fraction CyberKnife radiotherapy for large brain metastases in critical areas: impact on the surrounding brain volumes circumscribed with a single dose equivalent of 14 Gy (V14) to avoid radiation necrosis. (2013)
  • Author(s): Inoue HK, Sato H, Seto K, Torikai K, Suzuki Y, Saitoh J, Noda SE, Nakano T.
  • Journal Title: J Radiat Res. Volume: 55(2) Issue: 2 Pages: 334-42
  • DOI: 10.1093/jrr/rrt127
  • Peer Reviewed
• [Journal Article] X irradiation changes dendritic spine morphology and density through reduction of cytoskeletal proteins in mature neurons. (2013)
  • Author(s): Shirai K, Mizui T, Suzuki Y, Okamoto M, Hanamura K, Yoshida Y, Hino M, Noda SE, Al-jahdari WS, Chakravarti A, Shirao T, Nakano T.
  • Journal Title: Radiat Res. Volume: 179 Issue: 6 Pages: 630-6
  • DOI: 10.1667/rr3098.1
  • Peer Reviewed
• [Journal Article] Three-fraction Cyberknife radiotherapy for brain metastases in critical areas: referring to the risk evaluating radiation necrosis and the surrounding brain volumes circumscribed with a single dose equivalence of 14Gy (V14) (2013)
  • Author(s): Hiroshi K. INOUE
  • Journal Title: Journal of Radiation Research Volume: 54(3) Issue: 4 Pages: 1-9
  • DOI: 10.1093/jrr/rrt006
  • Peer Reviewed
• [Journal Article] 婦人科腫瘍に対する腔内照射と組織内照射の併用（ハイブリッド小線源治療） (2013)
  • Author(s): 野田真永、大野達也、中野隆史
  • Journal Title: 臨床放射線 Volume: 58 Pages: 406-412
  • Peer Reviewed
• [Journal Article] Comparison of hematological toxicities between innovator and generic cisplatin formulations in cervical cancer patients treated with concurrent chemoradiotherapy. (2013)
  • Author(s): Oike T, Ohno T, Noda SE, Sato H, Tamaki T, Kiyohara H, Ando K, Nakano T.
  • Journal Title: J Radiat Res. Volume: 54 Issue: 3 Pages: 474-478
  • DOI: 10.1093/jrr/rrs121
  • Peer Reviewed
• [Journal Article] 子宮頸癌に対するイメージベース小線源治療の展望 (2012)
  • Author(s): 大野達也、野田真永、中野隆史
  • Journal Title: 臨床放射線 Volume: 57 Pages: 502-509
  • Peer Reviewed
• [Presentation] The report of preliminary results of linac-based stereotactic radiotherapy in 3 sessions for brain metastases in our institution. (2013)
  • Author(s): Shin-ei Noda, Takashi Nakano
  • Organizer: 第3回国際放射線神経生物学会大会
  • Place of Presentation: 沖縄