Developement of a noble technique in external-beam radiation therapy

• Project/Area Number: 24591838
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MIZOWAKI TAKASHI 京都大学, 医学(系)研究科(研究院), 准教授 (90314210)
• Co-Investigator(Kenkyū-buntansha): NORIHISA Yoshiki 京都大学, 大学院医学研究科, 助教 (90456898) ; INOKUCHI Haruo 京都大学, 大学院医学研究科, 助教 (60648880)
• Research Collaborator: IKEDA Itaru ; NAKAMURA Kiyonao ; YAMADA Masahiro
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 放射線治療 / 前立腺癌 / 寡分割照射 / 強度変調放射線治療 / 定位照射 / 定位放射線照射 / 画像誘導放射線治療 / 動体追尾照射

Outline of Final Research Achievements

We performed a clinical study: "assessment of the intrafractional internal prostate motions during external beam radiation therapy (C594)". We found that baseline drift significantly affected on the actually delivered dose distribution, while respiration-induced movement had much smaller impacts. In addition, Adding a 7 mm margin is adequate to conpensate the effects of intrafractional movements, including baseline drifts, of the prostate. We also concluded that 54 Gy in 15 fractions is the most adequate schedule for hypofractional approach to the prostate cancer, if both LQ and LQL models were taken into consideration. Base on the finding, we established and conducted a pilot clininal study for the evaluation of the safty of hypofractional stereotactic intensity-modulated radiation therapy (C751). As of the end of March 2015, 17 cases out of 25 patients required in this study had been registered.

Research Products

• [Journal Article] Impact of intrafractional prostate motion on simultaneous boost intensity-modulated radiotherapy to the prostate: A simulation study based on intrafractional motion in the prone position (2015)
  • Author(s): Ikeda I, Mizowaki T, Ono T, Yamada M, Nakamura M, Monzen H, Yano S, Hiraoka M
  • Journal Title: Medical Dosimetry Volume: 未定 Issue: 4 Pages: 325-32
  • DOI: 10.1016/j.meddos.2015.04.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 強度変調放射線治療（IMRT） (2015)
  • Author(s): 溝脇 尚志
  • Journal Title: Prostate Journal Volume: 未定
• [Journal Article] Assessment of interfractional prostate motion in patients immobilized in the prone position using a thermoplastic shell. (2014)
  • Author(s): Ikeda I, Mizowaki T, Sawada Y, Nakata M, Norihisa Y, Ogura M, Hiraoka M.
  • Journal Title: J Radiat Res Volume: 55 Issue: 1 Pages: 168-174
  • DOI: 10.1093/jrr/rrt089
  • NAID: 120005373208
  • Peer Reviewed / Open Access
• [Journal Article] Long-term outcomes of dynamic conformal arc irradiation combined with neoadjuvant hormonal therapy in Japanese patients with T1c-T2N0M0 prostate cancer: case series study. (2014)
  • Author(s): Ikeda I, Mizowaki T, Norihisa Y, Takayama K, Kamba T, Inoue T, Nakamura E, Kamoto T, Ogawa O, Hiraoka M.
  • Journal Title: Jpn J Clin Oncol Volume: 44 Issue: 2 Pages: 180-185
  • DOI: 10.1093/jjco/hyt197
  • Peer Reviewed
• [Journal Article] 強度変調放射線治療（IMRT） (2013)
  • Author(s): 溝脇尚志
  • Journal Title: Prostate Cancer Front Line Volume: 2(3) Pages: 2-7
• [Presentation] Intensity-modulated radiation therapy for prostate cancer: current status and perspectives in Japan (2015)
  • Author(s): Takashi Mizowaki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2015-05-25 – 2015-05-29
  • Invited
• [Presentation] X線外部照射療法：最新の知見 (2015)
  • Author(s): 溝脇尚志
  • Organizer: 第15回泌尿器腫瘍放射線治療研究会
  • Place of Presentation: ナレッジキャピタルカンファレンスセンター大阪
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] 高リスク前立腺癌に対する外部照射療法における全骨盤照射の意義 (2014)
  • Author(s): 溝脇尚志、井口治男、中村清直、神波大己、井上貴博、山崎俊成、小林 恭、小川 修、平岡真寛
  • Organizer: 第30回前立腺シンポジウム
  • Place of Presentation: 東京コンファレンスセンター・品川
  • Year and Date: 2014-12-13 – 2014-12-14
  • Invited
• [Presentation] Vero 4DRTとNovalisでの前立腺癌IMRTにおける急性期有害事象の比較検討 (2014)
  • Author(s): 中村清直、溝脇尚志、井口治男、池田格、井上貴博、神波大己、小川修、平岡真寛
  • Organizer: 日本放射線腫瘍学会第27回学術大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] X線外部照射療法 (2014)
  • Author(s): 溝脇尚志
  • Organizer: 第10回泌尿器腫瘍放射線研究会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-08-30
  • Invited
• [Presentation] 限局期前立腺癌に対する78Gy高線量強度変調放射線治療における晩期障害の長期観察 (2014)
  • Author(s): 井口治男、溝脇尚志、高山賢二、則久佳毅、池田格、小林恭、神波大己、井上貴博、小川修、平岡真寛
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] 強度変調放射線治療 (2014)
  • Author(s): 溝脇尚志
  • Organizer: 第43回放射線による制癌シンポジウム
  • Place of Presentation: メルパルク京都
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] Long-term outcome of high-dose IMRT with neoadjuvant hormonal therapy under early salvage policy for localized prostate cancer (2014)
  • Author(s): Takashi Mizowaki, Kenji Takayama, Yoshiki Norihisa, Itaru Ikeda,Tomomi Kamba, Toshiyuki Kamoto, Takahiro Inoue,Eijiro Nakamura, Osamu Ogawa and Masahiro Hiraoka
  • Organizer: 73rd Annual Meeting of the Japan Radiological Society
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-04-11 – 2014-04-14
  • Invited
• [Presentation] Long-term outcome of IMRT with neoadjuvant hormonal therapy under early salvage policy for T3-4N0M0 prostate cancer. (2014)
  • Author(s): Mizowaki T, Takayama K, Norihisa Y, Ikeda I, Kamba T, Kamoto T, Inoue T, Nakamura E, Ogawa O, Hiraoka M
  • Organizer: ESTRO 33
  • Place of Presentation: Vienna, Austria
• [Presentation] B期前立腺癌に対するネオアジュバント内分泌療法併用高線量IMRTの長期治療成績. (2014)
  • Author(s): 溝脇尚志, 高山賢二, 則久佳毅, 井口治男, 池田格, 神波大己, 賀本敏行, 井上貴博, 小川修, 平岡真寛
  • Organizer: 第27回日本高精度放射線外部照射研究
  • Place of Presentation: 東京
• [Presentation] Long-term outcome of high-dose IMRT with neoadjuvant hormonal therapy under early salvage policy for localized prostate cancer. (2014)
  • Author(s): Mizowaki T, Takayama K, Norihisa Y, Ikeda I, Kamba T, Kamoto T, Inoue T, Nakamura E, Ogawa O, Hiraoka M
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Relationship Between Intra-fraction Prostate Motion And Rectal Dilatation. (2014)
  • Author(s): Ikeda I, Mizowaki T, Nakamura M, Yano S, Yamada M, Inokuchi H, Norihisa Y, Hiraoka M
  • Organizer: 2nd International Symposium of Training Plan for Oncology Professionals
  • Place of Presentation: Osaka, Japan
• [Presentation] Guidelines of prostate cancer in Japan. (2013)
  • Author(s): Mizowaki T
  • Organizer: 5th China-Japan-Korea Trilateral Symposium on Radiation Oncology
  • Place of Presentation: Chengdu, China
  • Invited
• [Presentation] Vero4DRT（MHI-TM2000）を用いた動体追尾照射におけるマージン設定 (2013)
  • Author(s): 溝脇尚志, 松尾幸憲, 植木奈美, 中村晶, 飯塚裕介, 中村光宏, 石原佳知, 宮部結城, 秋元麻未, 椋本宜学, 平岡真寛
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] C期前立腺癌に対するネオアジュバント内分泌療法併用高線量IMRTの長期治療成績 (2013)
  • Author(s): 溝脇尚志, 高山賢二, 則久佳毅, 井口治男, 池田格, 神波大己, 賀本敏行, 井上貴博, 小川修, 平岡真寛
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] C期前立腺癌に対するネオアジュバント内分泌療法併用高線量IMRTの長期治療成績 (2013)
  • Author(s): 溝脇尚志, 高山賢二, 則久佳毅, 井口治男, 池田格, 神波大己, 賀本敏行, 中村英二郎, 井上貴博, 清水洋祐, 小川修, 平岡真寛
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] 限局性前立腺癌に対する早期救済ポリシー下でのネオアジュバント内分泌療法併用高線量IMRTの長期治療成績 (2013)
  • Author(s): 溝脇尚志, 井口治男, 池田格, 中村京平, 神波大己, 井上貴博, 山崎俊成, 小林恭, 小川修, 平岡真寛
  • Organizer: 第29回前立腺シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] Relationship Between Intra-fraction Prostate Motion And Rectal Dilatation. (2013)
  • Author(s): Ikeda I, Mizowaki T, Nakamura M, Yano S, Yamada M, Inokuchi H, Norihisa Y, Hiraoka M
  • Organizer: ASTRO 55
  • Place of Presentation: Atlanta, USA
• [Presentation] 前立腺癌腹臥位シェル固定下IMRTにおける呼吸性移動の影響 (2013)
  • Author(s): 池田格,溝脇尚志,小野智博,門前一,中村京平,中村光宏,矢野慎輔,井口治男,平岡真寛
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] Impact of MLC leaf width on incidence of the late rectal bleeding after intensity-modulated radiotherapy for localized prostate carcinoma. (2013)
  • Author(s): H. Inokuchi, T. Mizowaki, Y. Norihisa, K. Takayama, I. Ikeda, M. Hiraoka
  • Organizer: ASTRO 55
  • Place of Presentation: Atlanta, USA
• [Presentation] 前立腺強度変調放射線治療における標準化と個別化 (2013)
  • Author(s): 溝脇尚志
  • Organizer: 第26回日本高精度放射線外部照射研究会
  • Place of Presentation: 京都テルサ
  • Invited
• [Presentation] 救済放射線療法 (2013)
  • Author(s): 溝脇尚志
  • Organizer: 第15回前立腺癌臨床課題研究会
  • Place of Presentation: 東京パレスホテル
  • Invited
• [Presentation] Interim Outcomes of a High-dose Whole Pelvic IMRT for Very High-risk Group of Patients With Locally Advanced Prostate Cancer. (2012)
  • Author(s): T. Mizowaki, Y. Norihisa, M. Ogura, K. Takayama, T. Kamba, T. Inoue, Y. Shimizu, T. Kamoto, O. Ogawa, M. Hiraoka
  • Organizer: ASTRO 54th Annual Meeting
  • Place of Presentation: Boston, MA, USA
• [Presentation] 超高リスク局所進展前立腺癌に対する高線量全骨盤IMRTの初期治療成績 (2012)
  • Author(s): 溝脇尚志, 則久佳毅, 高山賢二, 神波大己, 井上貴博, 中村英二郎, 賀本敏行, 小川修, 平岡真寛
  • Organizer: 第8回泌尿器腫瘍放射線研究会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 腹臥位シェル固定下でのintra-fractional prostate motionの検討 (2012)
  • Author(s): 池田格, 溝脇尚志, 中村光宏, 矢野慎輔, 井口治男, 則久佳毅, 平岡真寛
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] IMRTのピットフォール（前立腺癌を中心に） (2012)
  • Author(s): 則久佳毅
  • Organizer: 第25回日本高精度放射線外部照射研究会
  • Place of Presentation: 広島国際会議場
  • Invited
• [Presentation] 限局期前立腺癌IMRTにおいてMLC幅が晩期直腸出血に与える影響 (2012)
  • Author(s): 井口治男,, 溝脇尚志, 高山賢二, 則久佳毅, 池田格, 平岡真寛
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京国際フォーラム
• [Book] Intensity-Modulated Radiation Therapy - Clinical Evidence and Techniques (2015)
  • Author(s): Editors: Yasumasa Nishimura,Ritsuko Komaki
  • Publisher: Springer