Efficacy and tolerance of ultra high dose rate synchrotron irradiation
Project/Area Number |
24591840
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kobe University |
Principal Investigator |
OKAMOTO Yoshiaki 神戸大学, 医学(系)研究科(研究院), 講師 (20362791)
|
Co-Investigator(Kenkyū-buntansha) |
SASAKI Ryohei 医学部付属病院, 特命教授 (30346267)
YOSHIDA Kenji 神戸大学, 医学部附属病院, 特命講師 (80351906)
MIYAWAKI Daisuke 医学(系)研究科(研究院), 助教 (30546502)
FURUSE Motomasak 大阪医科大学, 医学部, 講師 (70340560)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 放射光 / Mirobeam / Spring-8 / スリット照射 / 線量率 / 白色X線 / 動物実験 / 高線量率 |
Outline of Final Research Achievements |
This study was prformed at Spring-8, Hyogo Japan, using synchrotron radiation. Normal tissue tolerance to ultra-high dose rate radiation was examined using C57/BL6 mice brain in vivo. The comparison between broad beam and several slit beams irradiation revealed that a LD50 of slitbeam (500 Gy)achieved approximately 7-folds higher than that of broad beam(70 Gy). Moreover, the slit beam irradiation did not cause severe neuronalcells loss. The slit beam irradiation to the brain did not induce abnormal behavior disorder in mice. The slit beam irradiation to the spinal cord did not cause any difference to that of broad beam irradiation.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Treatment Outcomes of Particle Radiotherapy Using Protons or Carbon Ions as a Single-Modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck2014
Author(s)
Masaru Takagi,Yusuke Demizu, Naoki Hashimoto, Masayuki Mima, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Yasue Niwa, Koichi Morimoto, Takashi Akagi, Takashi Daimon, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Masao Murakami, and Nobukazu Fuwa
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Journal Title
Radiotherapy and Oncology,
Volume: 113(3)
Issue: 3
Pages: 364-370
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prognostic Value of FDG PET Imaging in Patients with Laryngeal Cancer2014
Author(s)
Kitajima K, Suenaga Y, Kanda T, Miyawaki D, Yoshida K, Ejima Y, Sasaki R, Komatsu H, Saito M, Otsuki N, Nibu K, Kiyota N, Minamikawa T, Sugimura K.
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Journal Title
PLoS One
Volume: 9(5)
Issue: 5
Pages: e96999-e96999
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Transcutaneous application of CO2 enhances the antitumor effect of radiation therapy in human malignant fibrous histiocytoma.2014
Author(s)
Onishi Y, Akisue T, Kawamoto T, Ueha T, Hara H, Toda M, Harada R, Minoda M, Morishita M, Sasaki R, Nishida K, Kuroda R, Kurosaka M
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Journal Title
Int J Oncol.
Volume: 45(2)
Issue: 2
Pages: 732-738
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Particle therapy using carbon ions or protons as a definitive therapy for patients with primary sacral chordoma.2014
Author(s)
Mima M, Demizu Y, Jin D, Hashimoto N, Takagi M, Terashima K, Fujii O, Niwa Y, Akagi T, Daimon T, Hishikawa Y, Abe M, Murakami M, Sasaki R, Fuwa N.
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Journal Title
Br J Radiol.
Volume: 87(1033)
Issue: 1033
Pages: 20130512-20130512
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Retrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastases2014
Author(s)
Y Ejima, K Kakutani, Y Sakai, K Yoshida, D Miyawaki, H Uezono, H Hara, T Akisue, K Nishida, R Sasaki
Organizer
The 15th Asian Oceanian Congress of Radiology
Place of Presentation
Kobe, Japan
Year and Date
2014-09-24 – 2014-09-28
Related Report
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[Presentation] A Novel Radiosensitizer, Monogalactosyl diacylglycerol, Enhanced the Cytotoxic Effects for the Pancreatic Cancer2014
Author(s)
H Akasaka, R Sasaki, I Takayama, M Nakahana, NS Sulaiman, D Miyawaki, K Yoshida, Y Ejima, H Uezono, Y Mizushina
Organizer
European Society for Radiotherapy & Oncology 33
Place of Presentation
Vienna, Austria
Year and Date
2014-04-04 – 2014-04-08
Related Report
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