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Effects of oxygenation on radiosensitivity for hypoxic tumor cells.

Research Project

Project/Area Number 24591844
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

OGAWA KAZUHIKO  大阪大学, 医学(系)研究科(研究院), 教授 (40253984)

Co-Investigator(Kenkyū-buntansha) MATSUSHITA Masayuki  琉球大学, 医学部, 教授 (30273965)
ISHIUCHI Syogo  琉球大学, 医学(系)研究科(研究院), 教授 (10312878)
YOSHIMI Naoki  琉球大学, 医学(系)研究科(研究院), 教授 (30166996)
KOSHI Kiyotaka  琉球大学, 医学部附属病院, その他 (90195660)
Co-Investigator(Renkei-kenkyūsha) MURAYAMA Sadayuki   (60239548)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords低酸素腫瘍細胞 / 放射線抵抗性に関わる機序 / 放射線治療効果 / 遺伝子発現 / 酸素化 / 放射線抵抗性にかかわる機序
Outline of Final Research Achievements

This study has investigated the effects and the mechanisms of oxygenation on radiosensitivity for hypoxic malignant tumor cells. Our results have indicated that hypoxic tumor cells irradiated under hypoxic conditions and oxygenation had significantly slow growth compared to those irradiated under hypoxic contitions. Furthermore, concering in vivo group treated by irradiation and hyperbaric oxygennation, 78 genes have down-regulated compared to the group treated by irradiation without HBO. Especillay, hypoxia and HIF-1-related genes, such as vascular endothelial growth factor and Insulin-like growth factor-binding protein, have prominently down-regulated. These results indicate that oxygenation affects and tumor growth delay and changes of gene expression for hypoxic tumor cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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