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Studies about a radiosensitizer that is clinically usable

Research Project

Project/Area Number 24591845
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionSapporo Medical University

Principal Investigator

SAKATA Koh-ichi  札幌医科大学, 医学部, 教授 (10235153)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords放射線治療 / 子宮頚部癌 / DNA修復 / PARP阻害剤 / ノギテカン / 放射線増感剤 / DNA2重鎖切断 / 相同組換え修復
Outline of Final Research Achievements

An inhibitor of Poly (ADP-ribose) polymerase-1 (PARP-1), Olaparib enhanced sensitivity to radiation and Camptothecin (CPT) at low concentrations and after relatively short exposure times such as 2 h. The radiosensitizing effect of olaprib was not dependent on the p53 status of tumor cells. These characteristics could be advantageous for clinical radiotherapy since tumor cells may be exposed to low concentrations of olaparib and/or may have different levels of p53 mutation. The combination of olaparib and CPT had a stronger radiosensitizing effect, indicating that combining a PARP inihibitor with a topoiomerase I inhibitor could be promising for clinical radiosensitization.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2015 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy.2015

    • Author(s)
      Someya M, Yamamoto H, Nojima M, Hori M, Tateoka K, Nakata K, Takagi M, Saitoh M, Hirokawa N, Tokino T, Sakata K
    • Journal Title

      Radiotherapy and Oncology

      Volume: in press Issue: 2 Pages: 235-239

    • DOI

      10.1016/j.radonc.2015.04.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I study of oral S-1 and concurrent radiotherapy in patients with head and neck cancer.2013

    • Author(s)
      Nakata K, Sakata K, Someya M, Miura K, Hayashi J, Hori M, Takagi M, Himi T, Kondo A, Hareyama M.
    • Journal Title

      J Radiat Res

      Volume: 54(4) Issue: 4 Pages: 679-683

    • DOI

      10.1093/jrr/rrs133

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The combination of olaparib and camptothecin for effective radiosensitization2012

    • Author(s)
      Katsutoshi Miura
    • Journal Title

      Radiation Oncology

      Volume: 7 Issue: 1 Pages: 62-62

    • DOI

      10.1186/1748-717x-7-62

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The Combination of Olaparib and Camptothecin Effectively Sensitize Radiation2012

    • Author(s)
      Koh-ichi Sakata
    • Organizer
      American Society for Therapeutic Radiology and Oncology, 54th annual meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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