Development of radiotherapy quality assurance system in clinical trials to evaluate advanced radiotherapy.

• Project/Area Number: 24591847
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Juntendo University
• Principal Investigator: ISHIKURA Satoshi 順天堂大学, 医学部, 客員准教授 (40407242)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 品質保証 / 放射線治療 / 臨床試験 / 多施設共同研究 / 強度変調放射線治療 / 国際協調

Outline of Final Research Achievements

In this study, we checked if a study coordinator can review and evaluate radiotherapy treatment planning of enrolled cases in a clinical trial. Then we investigated how to establish and manage radiotherapy quality assurance system in clinical trials to evaluate advanced radiotherapy.
The globally harmonized efforts will be imperative to develop and prevail advanced radiotherapy.

Research Products

• [Journal Article] Global harmonization of quality assurance naming conventions in radiation therapy clinical trials. (2014)
  • Author(s): 1.Melidis C, Bosch WR, Izewska J, Fidarova E, Zubizarreta E, Ulin K, Ishikura S, Followill D, Galvin J, Haworth A, Besuijen D, Clark CH, Miles E, Aird E, Weber DC, Hurkmans CW, Verellen D.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 90 Issue: 5 Pages: 1242-1249
  • DOI: 10.1016/j.ijrobp.2014.08.348
  • Peer Reviewed
• [Journal Article] Radiation therapy quality assurance in clinical trials--Global Harmonisation Group. (2014)
  • Author(s): 2.Melidis C, Bosch WR, Izewska J, Fidarova E, Zubizarreta E, Ishikura S, Followill D, Galvin J, Xiao Y, Ebert MA, Kron T, Clark CH, Miles EA, Aird EG, Weber DC, Ulin K, Verellen D, Hurkmans CW.
  • Journal Title: Radiother Oncol Volume: 111 Issue: 3 Pages: 327-329
  • DOI: 10.1016/j.radonc.2014.03.023
  • Peer Reviewed
• [Presentation] Radiotherpay quality assurance for a multicenter prostate IMRT trial: a benchmark and an individual case review. (2015)
  • Author(s): 1.Ishikura S, Nakamura K, Mizowaki T, Shikama N, Nihei K, Kagami Y.
  • Organizer: The 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2015-05-25 – 2015-05-29
• [Presentation] An RTQA program in a multicenter prostate IMRT trial: a benchmark and an individual case review. (2014)
  • Author(s): 3.Ishikura S, Nakamura K, Mizowaki T, Shikama N, Nihei K, Kagami Y.
  • Organizer: The 33rd ESTRO Annual Meeting
  • Place of Presentation: Reed Messe Vienna GmbH Congress Center
  • Year and Date: 2014-04-04 – 2014-04-08
• [Presentation] An RTQA program in a multicenter prostate IMRT trial: a benchmark and an individual case review. (2014)
  • Author(s): 2. Ishikura S, Nakamura K, Mizowaki T, Shikama N, Nihei K, Kagami Y.
  • Organizer: The 33rd ESTRO Annual Meeting
  • Place of Presentation: Vienna
• [Presentation] Harmonizing quality assurance procedures and corresponding naming conventions in clinical trials in radiotherapy. (2013)
  • Author(s): 1. Hurkmans CW, Ebert M, Xiao Y, Ishikura S, Weber DC, Zubizarreta E, Izewska J, Bosch WR, Clark C, Followill DS.
  • Organizer: The 2nd ESTRO Forum
  • Place of Presentation: Geneva
• [Presentation] Inter-observer variability of target volume definition in a multi-institutional trial of hypofractionated intensity-modulated radiotherapy using image-guided techniques for localized prostate cancer. (2012)
  • Author(s): Nakamura K, Akimoto T, Mizowaki T, Hatano K, Shikama N, Kodaira T, Nakamura N, Kozuka T, Ishikura S, Kagami Y.
  • Organizer: The 6th S. Takahashi Memorial Symposium & The 6th Japan-Us Cancer Therapy International Joint Symposium
  • Place of Presentation: 広島
• [Presentation] Harmonisation of quality assurance for clinical trials in radiotherapy. (2012)
  • Author(s): Melidis C, Bosch WR, Izewska J, Fidarova E, Ishikura S, Followill D, Galvin J, Haworth A, Kron T, Hurkmans CW.
  • Organizer: The 31st ESTRO Annual Meeting
  • Place of Presentation: Barcelona