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Dose dynamic susceptibility contrast MRI have a potential imaging biomaker after radiotherapy

Research Project

Project/Area Number 24591852
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionTokyo Medical University

Principal Investigator

NAKAYAMA Hidetsugu  東京医科大学, 医学部, 准教授 (20436273)

Co-Investigator(Kenkyū-buntansha) TOKUUYE Koichi  東京医科大学, 医学部, 教授 (00334061)
HISHIDA Hirotoshi  工学院大学, 工学部, 准教授 (60373966)
AKATA Souichi  東京医科大学, 医学部, 教授 (70246198)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsイメージングバイオマーカー / DSC MRI / 放射線治療 / 機能性MRI / 治療効果判定 / MRI / DSC MRI / バイオマーカー
Outline of Final Research Achievements

Radiotherapy causes physiological changes of microenvironment in tumor tissue, which may have potential as a predictive value for radiation response. This study was prospectively conducted to clarify whether dynamic susceptiblility contrast (DSC) MR imaging detects the microvascular change in tumor before and after radiotherapy. Patients who had brain metastases underwent stereotactic radiotherapy were assessed by DSC MR imaging. DSC MR imaging was performed within one week before SRT. DSC MR imaging parameters a relative blood volume (rCBV) and a relative cerebral blood volume (rCBF) were analyzed. The differences of rCBV ratios (p = 0.002) and rCBF ratios (p = 0.004) between pre-SRT and one month after SRT were statistically significance. Microvascluar flow in rCBV ratios and rCBF ratios were deceased prior to shrinking of tumor in contrast weighted T1 imaging. DSC MR imaging has possibility early imaging biomarker for tumor response after radiotherapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] Can dynamic susceptibly MRI be a potential imaging biomarker after radiotherapy?2014

    • Author(s)
      T Itonaga, H Nakayama, Y Tajima et al.
    • Organizer
      33Th. Annual meeting of european society for radiotherpay & oncology
    • Place of Presentation
      ウィーン
    • Related Report
      2013 Research-status Report
  • [Presentation] Dynamic susceptibly MRIによる放射線治療後のイメージングバイオマーカーとしての可能性2013

    • Author(s)
      白石沙眞 三上隆二 中山秀次
    • Organizer
      第444関東地方定期大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 転移性脳腫瘍のDSC MRIによる描出

    • Author(s)
      中山秀次
    • Organizer
      革新的医療技術創出研究会
    • Place of Presentation
      東京大学
    • Related Report
      2012 Research-status Report
  • [Presentation] DSC MRIによる定位放射線治療後の効果判定

    • Author(s)
      中山秀次
    • Organizer
      新都心画像研究会
    • Place of Presentation
      東京医科大学
    • Related Report
      2012 Research-status Report
  • [Remarks] 放射線治療部門の研究

    • URL

      http://rad-tmc.fiw-web.net/

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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