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A prophylaxis and a treatment for radiation induced mucosal damage in high risk radiotherapy patient

Research Project

Project/Area Number 24591854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionHyogo Medical University

Principal Investigator

KAMIKONYA NORIHIKO  兵庫医科大学, 医学部, 教授 (00185985)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Masayuki  兵庫医科大学, 医学部, 非常勤講師 (90388827)
TAKADA Yasuhiro  兵庫医科大学, 医学部, 助教 (20461048)
DOI Hiroshi  兵庫医科大学, 医学部, 助教 (50529047)
MAEDA Hiroaki  兵庫医科大学, 医学部, 助教 (00388828)
HIROTA Shozo  兵庫医科大学, 医学部, 教授 (20181216)
NIWA Yasue  兵庫医科大学, 医学部, 助教 (60648294)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords放射線障害 / 直腸粘膜障害 / 亜鉛 / 抗凝固剤 / 高齢者
Outline of Final Research Achievements

A total of 34 female Wistar rats were used. The rats were divided into five groups: aspirin 5 mg/kg/day group (ASA5), aspirin 10 mg/kg/day group (ASA10), aspirin 20 mg/kg/day (ASA20), and saline group (Saline). The rats were administered with aspirin at dose of 5, 10, 20 mg/kg or saline orally, day by day before and after irradiation. A single fraction of 25 Gy was delivered selectively for the rectum without any surgical procedures. The rectal mucosal changes of each rat were evaluated macroscopically and pathologically. There were no apparent correlation between the administration of aspirin and the severity of radiation proctitis in the macroscopic findings, and the morphological mucosal damage in the pathological examination. In the proportion of the severe changes and the morphological mucosal damage, the ASA20 group showed significantly milder inflammation than the other groups (p < 0.05).

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (28 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (18 results) (of which Invited: 3 results) Book (2 results)

  • [Journal Article] The timing of surgery after preoperative short-course S-1 chemoradiotherapy with delayed surgery for T3 lower rectal cancer2014

    • Author(s)
      Beppu Naohito, Matsubara Nagahide, Noda Masashi, Yamano Tomoki, Doi Hiroshi, Kamikonya Norihiko, Yamanaka Naoki, Yanagi Hidenori, Tomita Naohiro
    • Journal Title

      Int J Colorectal Dis.

      Volume: 29 Issue: 12 Pages: 1459-1466

    • DOI

      10.1007/s00384-014-1997-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathologic evaluation of the response of mesorectal positive nodes to preoperative chemoradiotherapy in patients with rectal cancer2014

    • Author(s)
      Beppu Naohito, Matsubara Nagahide, Noda Masashi, Yamano Tomoki, Doi Hiroshi, Kamikonya Norihiko, Yamanaka Naoki, Yanagi Hidenori, Tomita Naohiro
    • Journal Title

      Surgery

      Volume: 157 Issue: 4 Pages: 743-751

    • DOI

      10.1016/j.surg.2014.10.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predicting Delivery Error Using a DICOM-RT Plan for Volumetric Modulated Arc Therapy2014

    • Author(s)
      Miura H, Tanooka M, Fujiwara M, Takada Y, Doi H, Odawara S, Kosaka K, Kamikonya N and Hirota S
    • Journal Title

      nternational Journal of Medical Physics, Clinical Engineering and Radiation Oncology.

      Volume: 3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DICOM-RT Plan Complexity Verification for Volumetric Modulated Arc Therapy2014

    • Author(s)
      Miura H, Tanooka M, Inoue H, Fujiwara M, Kosaka K, Doi H, Takada Y, Odawara S, Kamikonya N, Hirota S
    • Journal Title

      International Journal of Medical Physics, Clinical Engineering and Radiation Oncology.

      Volume: 3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 直腸癌に対する化学療法併用 短期加速過分割放射線治療の短期成績2014

    • Author(s)
      土井啓至,別府直仁,柳秀憲,上紺屋憲彦,廣田省三
    • Journal Title

      臨床放射線

      Volume: 59

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART) combined with S-1 for locally advanced rectal cancer.2013

    • Author(s)
      Doi Hiroshi, Beppu Naohito, Odawara Soichi, Tanooka Masao, Takada Yasuhiro, Niwa Yasue, Fujiwara Masayuki, Kimura Fumihiko, Yanagi Hidenori, Yamanaka Naoki, Kamikonya Norihiko, Hirota Shozo.
    • Journal Title

      Journalof Radiation Reserch

      Volume: 54 Pages: 1118-24

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional radiochromic film dosimetry for volumetric modulated arc therapy using a spiral water phantom.2013

    • Author(s)
      Tanooka Masao, Doi Hiroshi, Miura Hideharu , Inoue Hiroyuki, Niwa Yasue, Takada Yasuhiro, Fujiwara Masayuki, Sakai Toshiyuki, Sakamoto Kiyoshi, Kamikonya Norihiko , Hirota Shozo.
    • Journal Title

      Journal of Radiation Reserch

      Volume: 54 Pages: 1153-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term sequential changes of radiation proctitis and angiopathy in rats.2012

    • Author(s)
      Doi H, Kamikonya N, Takada Y, Fujiwara M, Tsuboi K, Miura H, Inoue H, Tanooka M, Nakamura T, Shikata T, Kimura T, Tsujimura T, Hirota S.
    • Journal Title

      J Radiat Res

      Volume: 53 Pages: 217-224

    • NAID

      130001876825

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 放射線性障害に対する亜鉛製剤による治療効果の検証2014

    • Author(s)
      小田原聡、上紺屋憲彦
    • Organizer
      がんプロフェッショナル養成基盤推進プラン平成26年度近畿地区3拠点合同フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2014-12-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規分子標的治療薬の影響を受けたと考えられた晩期放射線性皮膚軟部組織障害の一例2014

    • Author(s)
      丹羽康江,髙田康弘,鈴木公美,小田原聡一,土井啓至,冨士原将之,田ノ岡征雄,井上裕之,上紺屋憲彦,廣田省三
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 放射線粘膜障害に対するポラプレジンク含嗽液の前向き臨床試験2014

    • Author(s)
      鈴木公美、土井啓至、冨士原将之、丹羽康江、小田原聡一、高田康弘、中山雅裕、志方敏幸、木村健、上紺屋憲彦、廣田省三
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫に対するVMAT後肝障害の画像的評価2014

    • Author(s)
      冨士原将之,小田原聡一,鈴木公美,小坂賢吾,樽谷和雄,髙田康弘,土井啓至,丹羽康江,上紺屋憲彦,廣田省三.
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 放射線腸管障害に対する亜鉛製剤による防護効果2014

    • Author(s)
      小田原聡一,土井啓至,辻村亨,志方敏幸,鈴木公美,小坂賢吾,井上裕之,田ノ岡征雄,髙田康弘,丹羽康江,冨士原将之,上紺屋憲彦,廣田省三
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 三次元半導体検出器を用いたVMATにおける線量分布検証法の確立に向けて2014

    • Author(s)
      井上 裕之、田ノ岡 征雄、小坂 賢吾、樽谷 和雄、若山 司、高田 康弘、土井 啓至、春井 章吾、冨士原 将之、門前 一、上紺屋 憲彦
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 治療RISを介在させない放射線治療情報システム構築と実運用の試み 第2報2014

    • Author(s)
      樽谷和雄 薮田和利 橋本貴生  田中雅之 藤井彩  上田恵吾 三輪大介 小坂賢吾 上紺屋憲彦 香川一史
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 当院における前立腺癌-125小線源療法の臨床的検討2014

    • Author(s)
      髙田康弘,鈴木公美,小田原聡一,土井啓至,丹羽康江,冨士原将之,井上裕之,田ノ岡征雄,坪井慶太,上紺屋憲彦,廣田省三
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of the complexity of volumetric modulated arc therapy treatment plan by the non-irradiation method using DICOM-RT2014

    • Author(s)
      Hiroyuki Inoue, Hideharu Miura, Masao Tanooka, Kengo Kosaka, Kazuo Tarutani, Mitsuhiro Shibayama, Etsuko Nakamura, Tsukasa Wakayama, Jun Uehigashi, Toshiyuki Sakai, Masahiko Oda, Katsumi Yasumasa, Masayuki Fujiwara, Norihiko Kamikonya
    • Organizer
      14th Asia-Oceania Congress of Medical Physics & 12th South East Asia Congress of Medical Physics
    • Place of Presentation
      Ho Chi Minh City, Vietnam
    • Year and Date
      2014-10-23 – 2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Polaprezinc Protects Intestinal Epithelium from Radiation-induced Damage in Mice2014

    • Author(s)
      Soichi Odawara, Hiroshi Doi, Tooru Tohru Tsujimura, toshiyuki Shikata, Hitomi Suzuki, Kengo Kosaka, Hiroyuki Inoue, Masao Tanooka, Yasuhiro Takada, Yasue Niwa, Masayuki Fujiwara, Norihiko Kamikonya, Shozo Hirota
    • Organizer
      ASTRO’s 56th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-09-14 – 2014-09-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hemithoracic radiotherapy for malignant pleural mesothelioma following and extra pleural pneumonectomy2014

    • Author(s)
      Soichi Odawara, Masayuki Fujiwara, Hiroshi Doi, Masao Tanooka, Yasuhiro Takada, Yasue Niwa, Seiki Hasegawa, Koji Nakano, Norihiko Kamikonya, Shozo Hirota
    • Organizer
      ESTRO
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-04-05 – 2014-04-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical experience of the reducing acute radiation dermatitis by coating skin with tape.テープ材によるビルドアップ効果と相反する皮膚反応を呈した臨床経験の報告.2013

    • Author(s)
      丹羽康江,田ノ岡征雄,小田原聡一,土井啓至,髙田康弘,冨士原将之,酒井敏行,和泉正幸,上紺屋憲彦,廣田省三
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 放射線治療後の晩期障害と高気圧酸素治療~現在の社会的背景と今後の展望~.2013

    • Author(s)
      丹羽康江,大江与喜子,不破信和,村上昌雄,上紺屋憲彦,廣田省三.
    • Organizer
      第23回日本臨床工学会
    • Place of Presentation
      山形
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 放射線治療に伴う粘膜障害は軽減できるのか?:亜鉛製剤の有用性に迫る.2013

    • Author(s)
      上紺屋憲彦
    • Organizer
      第62回中国・四国放射線治療懇話会
    • Place of Presentation
      島根
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Safety and adverse events of neoadjuvant short- course hypoerfractionationed accelerated radiotherapy (SC-HART) combined with chemotherapy for rectal cancer2013

    • Author(s)
      Doi Hiroshi, Beppu Naohito, Odawara Soichi, Tanooka Masao, Takada Yasuhiro, Niwa Yasue, Fujiwara Masayuki, Kimura Fumihiko, Yanagi Hidenori, Yamanaka Naoki, Kamikonya Norihiko, Hirota Shozo.
    • Organizer
      ECCO2013(The European Cancer Congress)
    • Place of Presentation
      Amsterdam, Nederland
    • Related Report
      2013 Research-status Report
  • [Presentation] 前立腺癌強度変調放射線治療時の膀胱容量に関する要因分析2013

    • Author(s)
      髙田康弘,小田原聡一,土井啓至,丹羽康江,冨士原将之,三浦英治,井上裕之,田ノ岡征雄,坪井慶太,上紺屋憲彦,廣田省三
    • Organizer
      日本放射線腫瘍学会第26回学術大会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 放射線治療2013

    • Author(s)
      上紺屋憲彦
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Is obesity correlated with gastrointestinal toxicity induced by radiotherapy for prostate cancer?2012

    • Author(s)
      Doi H, Ishimaru F, Tanooka M, Miura H, Inoue H, Takada Y, Fujiwara M, Yamamoto S, Kamikonya N, Hirota S.
    • Organizer
      European Society for Therapeutic Radiology and Oncology
    • Place of Presentation
      Barcelona Spain
    • Related Report
      2012 Research-status Report
  • [Book] 放射線医学放射線腫瘍学2012

    • Author(s)
      上紺屋憲彦
    • Total Pages
      176
    • Publisher
      京都:金芳堂
    • Related Report
      2012 Research-status Report
  • [Book] 臨床放射線腫瘍学‐最新知見に基づいた放射線治療の実践.2012

    • Author(s)
      上紺屋憲彦
    • Total Pages
      536
    • Publisher
      東京:南江堂
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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