A prophylaxis and a treatment for radiation induced mucosal damage in high risk radiotherapy patient
Project/Area Number |
24591854
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Hyogo Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Masayuki 兵庫医科大学, 医学部, 非常勤講師 (90388827)
TAKADA Yasuhiro 兵庫医科大学, 医学部, 助教 (20461048)
DOI Hiroshi 兵庫医科大学, 医学部, 助教 (50529047)
MAEDA Hiroaki 兵庫医科大学, 医学部, 助教 (00388828)
HIROTA Shozo 兵庫医科大学, 医学部, 教授 (20181216)
NIWA Yasue 兵庫医科大学, 医学部, 助教 (60648294)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 放射線障害 / 直腸粘膜障害 / 亜鉛 / 抗凝固剤 / 高齢者 |
Outline of Final Research Achievements |
A total of 34 female Wistar rats were used. The rats were divided into five groups: aspirin 5 mg/kg/day group (ASA5), aspirin 10 mg/kg/day group (ASA10), aspirin 20 mg/kg/day (ASA20), and saline group (Saline). The rats were administered with aspirin at dose of 5, 10, 20 mg/kg or saline orally, day by day before and after irradiation. A single fraction of 25 Gy was delivered selectively for the rectum without any surgical procedures. The rectal mucosal changes of each rat were evaluated macroscopically and pathologically. There were no apparent correlation between the administration of aspirin and the severity of radiation proctitis in the macroscopic findings, and the morphological mucosal damage in the pathological examination. In the proportion of the severe changes and the morphological mucosal damage, the ASA20 group showed significantly milder inflammation than the other groups (p < 0.05).
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] DICOM-RT Plan Complexity Verification for Volumetric Modulated Arc Therapy2014
Author(s)
Miura H, Tanooka M, Inoue H, Fujiwara M, Kosaka K, Doi H, Takada Y, Odawara S, Kamikonya N, Hirota S
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Journal Title
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology.
Volume: 3
Related Report
Peer Reviewed
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[Journal Article] Neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART) combined with S-1 for locally advanced rectal cancer.2013
Author(s)
Doi Hiroshi, Beppu Naohito, Odawara Soichi, Tanooka Masao, Takada Yasuhiro, Niwa Yasue, Fujiwara Masayuki, Kimura Fumihiko, Yanagi Hidenori, Yamanaka Naoki, Kamikonya Norihiko, Hirota Shozo.
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Journal Title
Journalof Radiation Reserch
Volume: 54
Pages: 1118-24
Related Report
Peer Reviewed
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[Journal Article] Three-dimensional radiochromic film dosimetry for volumetric modulated arc therapy using a spiral water phantom.2013
Author(s)
Tanooka Masao, Doi Hiroshi, Miura Hideharu , Inoue Hiroyuki, Niwa Yasue, Takada Yasuhiro, Fujiwara Masayuki, Sakai Toshiyuki, Sakamoto Kiyoshi, Kamikonya Norihiko , Hirota Shozo.
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Journal Title
Journal of Radiation Reserch
Volume: 54
Pages: 1153-9
Related Report
Peer Reviewed
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[Journal Article] Long-term sequential changes of radiation proctitis and angiopathy in rats.2012
Author(s)
Doi H, Kamikonya N, Takada Y, Fujiwara M, Tsuboi K, Miura H, Inoue H, Tanooka M, Nakamura T, Shikata T, Kimura T, Tsujimura T, Hirota S.
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Journal Title
J Radiat Res
Volume: 53
Pages: 217-224
NAID
Related Report
Peer Reviewed
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[Presentation] Evaluation of the complexity of volumetric modulated arc therapy treatment plan by the non-irradiation method using DICOM-RT2014
Author(s)
Hiroyuki Inoue, Hideharu Miura, Masao Tanooka, Kengo Kosaka, Kazuo Tarutani, Mitsuhiro Shibayama, Etsuko Nakamura, Tsukasa Wakayama, Jun Uehigashi, Toshiyuki Sakai, Masahiko Oda, Katsumi Yasumasa, Masayuki Fujiwara, Norihiko Kamikonya
Organizer
14th Asia-Oceania Congress of Medical Physics & 12th South East Asia Congress of Medical Physics
Place of Presentation
Ho Chi Minh City, Vietnam
Year and Date
2014-10-23 – 2014-10-25
Related Report
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[Presentation] Polaprezinc Protects Intestinal Epithelium from Radiation-induced Damage in Mice2014
Author(s)
Soichi Odawara, Hiroshi Doi, Tooru Tohru Tsujimura, toshiyuki Shikata, Hitomi Suzuki, Kengo Kosaka, Hiroyuki Inoue, Masao Tanooka, Yasuhiro Takada, Yasue Niwa, Masayuki Fujiwara, Norihiko Kamikonya, Shozo Hirota
Organizer
ASTRO’s 56th Annual Meeting
Place of Presentation
San Francisco, USA
Year and Date
2014-09-14 – 2014-09-17
Related Report
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[Presentation] Hemithoracic radiotherapy for malignant pleural mesothelioma following and extra pleural pneumonectomy2014
Author(s)
Soichi Odawara, Masayuki Fujiwara, Hiroshi Doi, Masao Tanooka, Yasuhiro Takada, Yasue Niwa, Seiki Hasegawa, Koji Nakano, Norihiko Kamikonya, Shozo Hirota
Organizer
ESTRO
Place of Presentation
Vienna, Austria
Year and Date
2014-04-05 – 2014-04-07
Related Report
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[Presentation] Safety and adverse events of neoadjuvant short- course hypoerfractionationed accelerated radiotherapy (SC-HART) combined with chemotherapy for rectal cancer2013
Author(s)
Doi Hiroshi, Beppu Naohito, Odawara Soichi, Tanooka Masao, Takada Yasuhiro, Niwa Yasue, Fujiwara Masayuki, Kimura Fumihiko, Yanagi Hidenori, Yamanaka Naoki, Kamikonya Norihiko, Hirota Shozo.
Organizer
ECCO2013(The European Cancer Congress)
Place of Presentation
Amsterdam, Nederland
Related Report
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