Research on new mechanism for radioprotective effect of FGF12
Project/Area Number |
24591856
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | National Institute of Radiological Sciences |
Principal Investigator |
NAKAYAMA Fumiaki 独立行政法人放射線医学総合研究所, 重粒子医科学センター, チームリーダー (50277323)
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Co-Investigator(Renkei-kenkyūsha) |
IMAI Takashi 独立行政法人放射線医学総合研究所, 重粒子医科学センター, プログラムムリーダー (50183009)
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Research Collaborator |
UMEDA Sachiko
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 放射線障害 / 防護剤 / 治療薬 / 増殖因子 / 再生医療 / 蛋白質 / 放射線 / 細胞内移行 / 再生医学 / 生体分子 |
Outline of Final Research Achievements |
FGF12 can be internalized into cells using two domains (CPP-M, CPP-C). This study aimed at clarifying the role of FGF12 internalization in protection against radiation-induced intestinal injury. Administration of FGF12 into BALB/c mice after radiation exposure was as effective as pretreatment in significantly promoting intestinal regeneration from radiation damage. Two domains, comprising amino acid residues 80-109 and 140-169 of FGF12B, were identified as being responsible for the radioprotective activity. Interestingly, these regions included the CPP-M and CPP-C domains, respectively; however, CPP-C by itself did not show an anti-apoptotic effect. In addition, internalized FGF12 suppressed the activation of p38α after irradiation, resulting in reduced radiation-induced apoptosis. These findings indicate that FGF12 can protect the intestine against radiation-induced injury through its internalization, independently of FGFRs.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells.2013
Author(s)
T.Okada, K.Murata, R.Hirose, C.Matsuda, T.Komatsu, M.Ikekita, M.Nakawatari, F.Nakayama, M.Wakatsuki, T.Ohno, S.Kato, T.Imai, T.Imamura
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Journal Title
Scientific Reports
Volume: 3
Issue: 1
Pages: 2899-2899
DOI
Related Report
Peer Reviewed
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[Journal Article] Structural stability of human fibroblast growth factor-1 is essential for protective effects against radiation-induced intestinal damage2013
Author(s)
Nakayama, F., Umeda, S., Yasuda, T., Asada, M., Motomura, K., Suzuki, M., Zakrzewska, M., Imamura, T., and Imai, T
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Journal Title
Int. J. Radiat. Biol. Phys.
Volume: 85
Issue: 2
Pages: 477-483
DOI
Related Report
Peer Reviewed
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[Journal Article] Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines2013
Author(s)
Nakayama, F., Umeda, S., Ichimiya, T., Kamiyama, S., Hazawa, M., Yasuda, T., Nishihara, S., Imai, T
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Journal Title
FEBS Letters
Volume: 587
Issue: 2
Pages: 231-237
DOI
Related Report
Peer Reviewed
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