Study of radiation responses via tumor-normal cell interaction

• Project/Area Number: 24591857
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: Shimokawa Takashi 国立研究開発法人放射線医学総合研究所, 重粒子医科学センター, チームリーダー (20608137)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 細胞間相互作用 / 放射線 / がん細胞 / 正常細胞 / 放射線応答 / 放射線科学

Outline of Final Research Achievements

This project aimed to clarify impact of microenvironment, especially interaction between cancer cells and stromal cells (normal cells), on radiation response of cancer cells. By using culture cells and mouse models, we showed that presence of normal cells surround of cancer cells significantly influenced radiation response of cancer cells. In addition, it has been shown that Wnt and Hedgehog signal pathways contribute greatly to radiation effects of cancer cells during the process. We had presented our findings at international conferences. A part of results was published in an international journal, and others have been in submission to international journals.

Research Products

• [Journal Article] Heterochromatin domain number correlates with X-ray and carbon-ion radiation resistance in cancer cells (2014)
  • Author(s): Sato K, Imai T, Okayasu R, Shimokawa T.
  • Journal Title: Radiat. Res. Volume: 182 Issue: 4 Pages: 408-419
  • DOI: 10.1667/rr13492.1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Biological Research at HIMAC, NIRS: Biological advantages of Carbon ion irradiation for cancer therapy (2015)
  • Author(s): Shimokawa, T
  • Organizer: IAEA Technical Meeting on Radiation Biology of Charged Particle Therapy
  • Place of Presentation: Vienna, Austoria
  • Year and Date: 2015-11-11
  • Invited
• [Presentation] Immune response modulation with 12C ion therapy? (2015)
  • Author(s): Shimokawa T
  • Organizer: the second annual International Symposium on Ion Therapy (ISIT)
  • Place of Presentation: Dallas, U.S.A.
  • Year and Date: 2015-10-15
  • Int'l Joint Research / Invited
• [Presentation] Homologous recombination repair is enhanced in X-ray and carbon ion beam resistant cancer cells (2015)
  • Author(s): Sato, K, Imai, T, Shimokawa, T
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Repeated g-ray irradiation but not C-ion irradiation promotes malignant progression of regrown tumor. (2015)
  • Author(s): Sato K, Ma L, Sakamoto Y, Imai T, Shimokawa T
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25 – 2015-05-29
• [Presentation] Repeated γ-ray irradiation but not C-ion irradiation promotes malignant progression of regrown tumor (2015)
  • Author(s): Sato, K, Ma, L, Sakamoto, Y, Imai, T, Shimokawa, T
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Elucidating the Mechanisms Behind Radiation Induced Pneumonitis and Pulmonary Fibrosis. (2015)
  • Author(s): Shimokawa, T, Fujita, H, Sato, K, Saito-Fujita, T, Ma, L, Ando, K, Irie, D, Imai, T
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] 放射線治療後の再増殖腫瘍モデルの樹立と これらの性質変化の解析 (2014)
  • Author(s): Sato K, Imai T, Shimokawa T
  • Organizer: 第57回 放射線影響学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-01 – 2014-10-03
  • Invited
• [Presentation] Repeated carbon ion beam irradiations confer the carbon ion beam resistance but not X-ray resistance in cancer cells. (2014)
  • Author(s): Sato K, Imai T, Shimokawa T
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Identification of Molecular Markers to Develop Carbon ion therapy. (2014)
  • Author(s): 下川卓志
  • Organizer: 広島大原医研国際シンポジウム
  • Place of Presentation: 広島
  • Invited
• [Presentation] Heterochromatin focus number correlates with X-ray and carbon ion beam resistance in cancer cells. (2013)
  • Author(s): Sato, K Imai, T Shimokawa, T
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
• [Presentation] Analysis of underlying mechanisms for combination therapy of carbon-ion irradiation and dendritic cell immunotherapy. (2013)
  • Author(s): Shimokawa, T Fujita, H Hosoi, A Sato, K Kakimi, K Imai, T
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
• [Presentation] Combination of Carbon-ion Irradiation and Immunotherapy in Mouse Models (2013)
  • Author(s): Shimokawa, T
  • Organizer: NIRS & MedAustron Joint Symposium on Carbon Ion Radiotherapy
  • Place of Presentation: Wiener Neustadt, Austria
  • Invited
• [Presentation] Establishment and characterization of novel carbon-ion beam resistance cells (2013)
  • Author(s): Sato, K Irie, D Nakawatari, M Nakamura, E Moritake, H Imai, T Shimokawa, T
  • Organizer: Heavy Ion in Therapy and Space Radiation Symposium 2013 (HITSRS2013)
  • Place of Presentation: Chiba
• [Presentation] Next-Generation Sequencing for Identification of Molecular markers in Prognosis of Carbon ion therapy. (2013)
  • Author(s): 下川卓志
  • Organizer: 広島大原医研国際シンポジウム
  • Place of Presentation: 広島
  • Invited
• [Presentation] 重粒子線－樹状細胞併用療法による転移制御の検討 (2013)
  • Author(s): 下川卓志
  • Organizer: 文部科学省 新学術領域研究「がん支援」個体レベルワークショップ
  • Place of Presentation: 大津
  • Invited