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Role of cancer stem in determining radiosensitivity in vitro and in vivo

Research Project

Project/Area Number 24591860
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

Akimoto Tetsuo  国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (10261851)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords放射線感受性 / がん幹細胞 / 放射線抵抗性 / 放射線生物学 / 放射線治療 / HPV感染 / 頭頚部癌 / 治療抵抗性 / 頭頸部癌 / 放射線応答 / 放射線生物
Outline of Final Research Achievements

The main purpose of this study is to establish effective radiosensitizing approach based in the role of cancer stem cells in determining radiosensitivity and/or cellular response to cancer cells. In 2013 and 2014, we performed basic research using cultured cancer cells, and then, we investigated the correlation between clinical outcomes after definitive IMRT for oropharyngeal cancer and the expression of p16 and CD44, cancer stem cell marker. Finally, we demonstrated that the PFS and LRC rates in the CD44(-) patients (86% and 93%, respectively) were significantly higher than those in the CD44(+) patients (57% and 70%, respectively), and concluded that profiling of CD44 and p16 protein expressions by immunohistochemical staining is useful for predicting the treatment outcomes in patients with OPSCC undergoing definitive intensity modulated radiation therapy.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 4 results) Presentation (8 results) (of which Invited: 6 results) Book (1 results)

  • [Journal Article] Impact of expression of CD44, a cancer stem cell marker, on the treatment outcomes of intensity-modulated radiotherapy in patients with oropharyngeal squamous cell carcinoma.2016

    • Author(s)
      Motegi A, Arahira S, Zenda S, Hayashi R, Fujii M, Akimoto T
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 94(3) Issue: 3 Pages: 461-468

    • DOI

      10.1016/j.ijrobp.2015.11.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phase II study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses2016

    • Author(s)
      Zenda S, Akimoto T, Mizumoto M, Hayashi R, Arahira S, Okumura T, Sakurai H
    • Journal Title

      Radiother Oncol

      Volume: 118(2) Issue: 2 Pages: 267-71

    • DOI

      10.1016/j.radonc.2015.10.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuropathic Pain Features in Patients with Bone Metastases2016

    • Author(s)
      Nakamura N, Takahashi O, Zenda S, Kawamori J, Ogita M, Onozawa M, Arahira S, Toshima M, Motegi A, Hirano Y, Hojo H, Akimoto T
    • Journal Title

      Clin Oncol (R Coll Radiol)

      Volume: 28 Issue: 3 Pages: 204-208

    • DOI

      10.1016/j.clon.2015.10.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phase II trial of chemoradiotherapy with S-1 plus cisplatin for unresectable locally advanced head and neck cancer (JCOG0706).2015

    • Author(s)
      ahara M, Kiyota N, Mizusawa J, Nakamura K, Hayashi R, Akimoto T, Hasegawa Y, Iwae S, Monden N, Matsuura K, Fujii H, Onozawa Y, Homma A, Kubota A, Fukuda H, Fujii M.
    • Journal Title

      Cancer Science

      Volume: 12 Issue: 6 Pages: 132-136

    • DOI

      10.1111/cas.12657

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between the changes in the EPIC QOL scores and the dose-volume histogram parameters in high-dose-rate brachytherapy combined with hypofractionated external beam radiation therapy for prostate cancer2015

    • Author(s)
      4.Hashimoto Y, Akimoto T, Iizuka J, Tanabe K, Mitsuhashi N.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 45(1) Issue: 1 Pages: 81-87

    • DOI

      10.1093/jjco/hyu173

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Accelerated radiotherapy for T1-T2 glottic cancer.2014

    • Author(s)
      Atsushi Motegi, Mitsuhiko Kawashima, Satoko Arahira, Sadamoto Zenda, Masamichi Toshima, Masakatsu Onozawa, Ryuichi Hayashi, Tetsuo Akimoto
    • Journal Title

      Head and Neck

      Volume: in press Issue: 4 Pages: 579-84

    • DOI

      10.1002/hed.23641

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Working Subgroup of Urological Cancers in Japanese Radiation Oncology Study Group. Patterns of practice in the radiation therapy for bladder cancer: survey of the Japanese Radiation Oncology Study Group (JROSG).2014

    • Author(s)
      5.Maebayashi T, Ishikawa H, Yorozu A, Yoshida D, Katoh H, Nemoto K, Ishihara S, Takemoto S, Ishibashi N, Tokumaru S, Akimoto T;
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44(11): Issue: 11 Pages: 1109-15

    • DOI

      10.1093/jjco/hyu129

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Accelerated radiotherapy for T1―T2 glottic cancer2014

    • Author(s)
      Motegi A, Akimoto T
    • Journal Title

      Head and Neck

      Volume: 23 Pages: 23-27

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase II Study of Cetuximab Plus Concomitant Boost Radiotherapy in Japanese Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck.2013

    • Author(s)
      1. Okano S, Yoshino T, Fujii M, Onozawa Y, Kodaira T, Fujii H, Akimoto T, Ishikura S, Oguchi M, Zenda S, de Blas B, Tahara M
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43(5) Pages: 476-82

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreatic resection for metastatic melanoma originating from the nasal cavity: a case report and literature review2013

    • Author(s)
      2. Sugimoto M, Gotohda N, Kato Y, Takahashi S, Kinoshita T, Shibasaki H, Kojima M, Ochiai A, Zenda S, Akimoto T, Konishi M
    • Journal Title

      Anticancer Res

      Volume: 33(2) Pages: 567-73

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 頭頸部癌の生物学多様性と放射線治療2015

    • Author(s)
      秋元
    • Organizer
      第17回癌治療増感研​究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2015-02-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 中咽頭癌におけるがん幹細胞マーカー発現とHPV感染の相関の研究2014

    • Author(s)
      茂木 厚、林 隆一、全田貞幹、秋元哲夫
    • Organizer
      日本放射線腫瘍学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-12-11 – 2014-12-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 中咽頭癌に対する強度変調放射線治療の遡及的検討2014

    • Author(s)
      茂木 厚、全田貞幹、荒平聡子、小野澤正勝、林 隆一、秋元哲夫
    • Organizer
      頭頚部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 頭頸部がん治療医の養成の現状と今後の方向について2014

    • Author(s)
      秋元哲夫
    • Organizer
      頭頚部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 生物学的アプローチと放射線治療の臨床2014

    • Author(s)
      秋元哲夫
    • Organizer
      第11回癌治療増感研究会シンポジウム
    • Place of Presentation
      奈良
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 化学放射線療法総論2013

    • Author(s)
      秋元哲夫
    • Organizer
      第51回日本癌治療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 分子生物学的見地からみた分子標的治療と放射線治療の併用の有用性と課題2013

    • Author(s)
      秋元哲夫
    • Organizer
      第26回日本放射線腫瘍学会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 食道癌に対する分子標的薬と放射線治療併用の安全性2013

    • Author(s)
      秋元哲夫
    • Organizer
      第11回日本臨床腫瘍学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] Intensity-Modulated Radiation Therapy2015

    • Author(s)
      Hidenobu Tachibana, Tetsuo Akimoto
    • Total Pages
      473
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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