Establishment of the method to detect endoleaks after stentgrafting using unenhanced MRI

• Project/Area Number: 24591864
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: University of Tsukuba
• Principal Investigator: Mori Kensaku 筑波大学, 医学医療系, 准教授 (80361343)
• Co-Investigator(Renkei-kenkyūsha): SAIDA Tsukasa 筑波大学, 医学医療系, 講師 (80719485) ; MINAMI Manabu 筑波大学, 医学医療系, 教授 (60309713) ; SATO Fujio 筑波大学, 医学医療系, 講師 (20375497) ; NASU Katsuhiro 筑波大学, 医学医療系, 講師 (30450571) ; OKAMOTO Yoshikazu 筑波大学, 医学医療系, 講師 (90420083) ; SHIIGAI Masanari 筑波大学, 附属病院, 病院講師 (90535056)
• Research Collaborator: YABE Hitoshi ; SHINDO Masayuki ; YAMADA Kouji ; TOKI Taketo
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 大動脈瘤 / ステントグラフト / エンドリーク / 検出 / 非造影 / MRI / aortic aneurysm / endoleak / unenhanced MR imaging / stentgraft

Outline of Final Research Achievements

The detection of endoleaks is important to prevent late aortic aneurysm rupture after endovascular aneurysm repair (EVAR). For this purpose, contrast-enhanced computed tomography (CE-CT) is most widely used; however we often encounter the cases, where CE-CTis contraindicated due to renal dysfunction.
To evaluate the feasibility of unenhanced MRI using motion-sensitized driven equilibrium (MSDE) prepared balanced turbo field echo (BTFE) sequences for the detection of endoleaks after EVAR, we performed a phantom study using a pulsatile flow generator and a clinical study with CE-CT as the reference standard. As a result, the MSDE prepared BTFE sequences were clinically feasible and provided high diagnostic performance.

Research Products

• [Journal Article] Endoleak detection after endovascular aneurysm repair using unenhanced MRI with flow suppression technique: Feasibility study in comparison with contrast-enhanced CT (2016)
  • Author(s): Mori K, Saida T, Sato F, Uchikawa Y, Konishi T, Ishiguro T, Hiyama T, Hoshiai S, Okamoto Y, Nasu K, Minami M
  • Journal Title: European Radiology Volume: 印刷中 Issue: 1 Pages: 336-344
  • DOI: 10.1007/s00330-016-4315-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Noninvasive visualization of endoleaks after endovascular aortic aneurysm repair through unenhanced MRI with motion-sensitized driven equilibrium preparation: Phantom experiments. (2013)
  • Author(s): Tsukasa Saida, Kensaku Mori, Hitoshi Yabe, Masashi Shindo, Katsuhiro Nasu, Masanari Shiigai, Hideto Takahashi, and Manabu Minami
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 未定 Issue: 3 Pages: 714-721
  • DOI: 10.1002/jmri.23993
  • Peer Reviewed
• [Presentation] Detection of endoleaks after endovascular aneurysm repair using unenhanced MRI: feasibility study of motion-sensitized driven equilibrium-prepared balanced turbo field echo sequences (2016)
  • Author(s): Mori K
  • Organizer: Bi-Annual Meeting 2016, German-Japanese Radiological Affiliation
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-06-02
  • Int'l Joint Research
• [Presentation] MSDE併用BTFE法を用いた非造影MRIによるステントグラフト内挿術後のエンドリーク検出 (2015)
  • Author(s): 森 健作，斎田 司，佐藤藤夫，内川容子，古西崇寛，石黒聡尚，檜山貴志，星合壮大，岡本嘉一，那須克宏，南 学
  • Organizer: 第43回日本磁気共鳴医学会総会
  • Place of Presentation: 東京ドームホテル（東京）
  • Year and Date: 2015-09-10
• [Presentation] Detection of endoleaks after endovascular aneurysm repair using unenhanced MR imaging:diagnostic accuracy of balanced turbo field echo sequencewith motion-sensitized driven equilibrium (2014)
  • Author(s): Kensaku Mori, Tsukasa Saida, Fujio Sato, Katsuhiro Nasu, Toshitaka Ishiguro, Takahiro Konishi, Yoko Uchikawa, Sodai Hoshiai, Takashi Hiyama, Manabu Minami
  • Organizer: Radiological Society of North America 2014 - 100th scientific assembly and annual meeting
  • Place of Presentation: Chicago, Ilinois, USA
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Noninvasive Visualization of Endoleaks after Endovascular Aortic Aneurysm Repair Using Unenhanced MR Imaging with Motion-sensitized Driven Equilibrium: Phantom Experiments (2012)
  • Author(s): Tsukasa Saida, Kensaku Mori, Hitoshi Yabe, Masashi Shindo, Katsuhiro Nasu, Masanari Shiigai, Hideto Takahashi, and Manabu Minami
  • Organizer: 98th Scientific Assembly and Annual Meeting of Radiologic Society of North America
  • Place of Presentation: Chicago, Ilinios, USA