Indication and timing of decease donor and living donor liver transplantation in Japan
Project/Area Number |
24591867
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SUGAWARA Yasuhiko 東京大学, 医学部大学院医学系研究科, 准教授 (90313155)
YAMASHIKI Noriyo 国際医療福祉大学, 保健医療学部, 講師 (90420215)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 肝移植 / 脳死肝移植 / 生体肝移植 / 臓器移植 / 肝硬変 / 肝不全 / 臓器提供 / C型肝炎 / 肝細胞癌 / 胆汁鬱滞性肝硬変 / C型肝炎 / 移植 / 脳死 / 生体 / 劇症肝炎 |
Outline of Final Research Achievements |
Organ transplantation requires organ donation from a donor. In liver transplantation, this is possible by donation from both living and deceased donor. In Japan, deceased donor is extremely limited. Living donation, however, requires sacrifice of an otherwise healthy family member. The aim of this project was to study the ideal indication and timing of both deceased and living donor liver transplantation to maximize utility and equity and to minimize the risk of living donors in the expected increase of decease donation following the revision of the law. During the scheduled period of the project, however, no increase in absolute number of deceased donation was observed. Currently, living donor liver transplantation remains the only reliable option to provide opportunity for survival. Further studies to increase the level of organ donation is mandatory.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Use of simeprevir following pre-emptive pegylated interferon/ribavirin treatment for recurrent hepatitis C in living donor liver transplant recipients: a 12-week pilot study2015
Author(s)
Tanaka T, Sugawara Y, Akamatsu N, Kaneko J, Tamura S, Aoki T, Sakamoto Y, Hasegawa K, Kurosaki M, Izumi N, Kokudo N
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 22
Issue: 2
Pages: 144-50
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Living donor liver transplantation: the Asian perspective.2014
Author(s)
Chen CL, Cheng YF, Yu CY, Ou HY, Tsang LL, Huang TL, Chen TY, Concejero A, Wang CC, Wang SH, Lin TS, Liu YW, Yang CH, Yong CC, Chiu KW, Jawan B, Eng HL, Chan SC, Sharr WW, Lo CM, Tamura S, et al
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Journal Title
Transplantation
Volume: 97
Issue: Supplement 8S
Pages: S3-S3
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of Early Reoperation following Living-Donor Liver Transplantation on Graft Survival2014
Author(s)
Kawaguchi Y, Sugawara Y, Akamatsu N, Kaneko J, Hamada T, Tanaka T, Ishizawa T, Tamura S, Aoki T, Sakamoto Y, Hasegawa K, Kokudo N
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Journal Title
PLoS One
Volume: 9
Issue: 11
Pages: e109731-e109731
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Telaprevir-based triple therapy for hepatitis C null responders among living donor liver transplant recipients2014
Author(s)
Kaneko J, Sugawara Y, Yamaguchi T, Harada N, Akamatsu N, Ishizawa T, Aoki T, Sakamoto Y, Hasegawa K, Tamura S, Tanaka T, Kokudo N.
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Journal Title
BioScience Trends
Volume: 8
Issue: 6
Pages: 339-345
DOI
NAID
ISSN
1881-7815, 1881-7823
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C2014
Author(s)
Harada N, Tamura S, Sugawara Y, Togashi J, Ishizawa T, Kaneko J, Aoki T, Sakamoto Y, Hasegawa K, Tanaka T, Yamashiki N, Kokudo N
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Journal Title
PLoS One
Volume: 9
Issue: 3
Pages: e90462-e90462
DOI
Related Report
Peer Reviewed
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[Presentation] Living donor liver transplantation for hepatocellular carcinoma.2014
Author(s)
Tamura S, Sugawara Y, Nagata R, Kaneko J, Tanaka T, Aoki T, Ishizawa Y, Sakamoto Y, Hasegawa K, Kokudo N.
Organizer
IHPBA world congress 2014
Place of Presentation
Seoul, Korea
Related Report
Invited
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[Presentation] Outcome after evaluation for Liver Transplantation in Patients with Primary Sclerosing Cholangitis.2013
Author(s)
Yamashiki N, Sugawara Y, Tamura S, Kaneko J, Togashi J, Tanaka T, Mizuno S, Hirano K, Isayama H, Koike K, Kokudo N.
Organizer
APASL Liver week
Place of Presentation
Singapore
Related Report
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[Presentation] Intraoperative Fluorescence Imaging of Hepatocellular carcinoma Using Indocyanine Green: Mechanistic Back ground and Clinical Applications.2013
Author(s)
Ishizawa T, Harada N, Miyata Y, Masuda K, Kawaguchi Y, Tamura S, Kaneko J, Aoki T, Sakamoto Y, Sugawara Y, Hasegawa K, Kokudo N.
Organizer
APASL Liver week
Place of Presentation
Singapore
Related Report
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[Presentation] Pre-emptive antiviral therapy for hepatitis C in living donor liver transplantation.2013
Author(s)
Tamura S, Sugawara Y, Yamashiki N, Kaneko J, Togashi J, Tanaka T, Hasegawa K, Aoki T, Ishizawa T, Sakamoto Y, Kokudo N.
Organizer
APASL Liver week
Place of Presentation
Singapore
Related Report
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[Presentation] Pre-emptive antiviral therapy for hepatitis C in living donor liver transplantation.2013
Author(s)
Tamura S, Sugawara Y, Yamashiki N, Kaneko J, Togashi J, Tanaka T, Hasegawa K, Aoki T, Ishizawa T, Sakamoto Y, Kokudo N.
Organizer
19th ILTS Annual international congress
Place of Presentation
Sydney, Australia
Related Report
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[Presentation] Treatment for hepatitis C in living donor liver transplantation.2013
Author(s)
Tamura S, Sugawara Y, Yamashiki N, Nojiri K, Tanaka T, Kaneko J, Hasegawa K, Aoki T, Ishizawa T, Sakamoto Y, Kokudo N.
Organizer
13th Congress of the Asian Society of Transplantation (CAST)
Place of Presentation
京都 京都国際会議場
Related Report
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[Presentation] Pre-emptive antiviral therapy for hepatitis C in living donor liver transplantation - Observation based on a single center experience.2012
Author(s)
Tamura S, Sugawara Y, Yamashiki N, Nojiri K, Kaneko J, Aoki T, Sakamoto Y, Hasegawa K, Kokudo N.
Organizer
The International Liver Transplantation Society 17th Annual Congress
Place of Presentation
Hilton San Francisco Union Square, San Francisco, CA, USA
Related Report
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[Presentation] Donor Morbidity and Recipient Outcome under Systematic Selection of Graft Types and Use of Cryo-Preserved Vein Grafts for Outflow Reconstruction in Living Donor Liver Transplantation: Outcomes of One Hundred Consecutive Adult-to-Adult Cases at a Single Center.2012
Author(s)
Tamura S, Sugawara Y, Yamashiki N, Nojiri K, Kaneko J, Aoki T, Sakamoto Y, Hasegawa K, Saito A, Motomura N, Kokudo N.
Organizer
The International Liver Transplantation Society 17th Annual Congress
Place of Presentation
Hilton San Francisco Union Square, San Francisco, CA, USA
Related Report
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[Presentation] Outcome Of Liver Transplantation for Acute Liver Failure In Japan; The Results from a Nationwide Survey.2012
Author(s)
Yamashiki N, Sugawara Y, Tamura S, Nakayama N, Oketani M, Umeshita K, Uemoto S, Mochida S, Tsubouchi H, Kokudo N.
Organizer
The International Liver Transplantation Society 17th Annual Congress
Place of Presentation
Hilton San Francisco Union Square, San Francisco, CA, USA
Related Report
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[Presentation] Hepatocellular Carcinoma and Living Donor Liver Transplantation2012
Author(s)
Tamura S, Sugawara Y, Yamashiki N, Nojiri K, Kaneko J, Aoki T, Sakamoto Y, Hasegawa K, Kokudo N
Organizer
22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologist
Place of Presentation
Shangri-la Hotel, Bangkok, Thailand
Related Report
Invited
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[Presentation] Donor morbidity and recipient outcome under systematic selection of graft types and use of cryo-preserved vein grafts for outflow reconstruction in living donor liver transplantation.2012
Author(s)
Tamura S, Sugawara Y, Kaneko J, Aoki S, Sakamoto Y, Hasegawa K, Saito A, Motomura N, Kokudo N.
Organizer
22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologist
Place of Presentation
Shangri-la Hotel, Bangkok, Thailand
Related Report
Invited