The fragility of macrovesicular fatty liver grafts during ischemia reperfusion injury
| Project/Area Number |
24591868
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUDO Atsushi 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (20376734)
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| Co-Investigator(Kenkyū-buntansha) |
田中 真二 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (30253420)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | microcirculation / 脂肪肝 / 肝動脈 / 肝移植 / 類洞 / 生体内異物解毒 / 解毒機構 |
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| Outline of Final Research Achievements |
It has been well known that sinusoidal reperfusion imbalance is observed in the liver grafts. In xenobiotic detoxification capacity of macrovesicular fatty liver grafts, the sinusoidal reperfusion of zonal heterogenity may determine the graft viability in the liver with or without Macrovesicular fatty liver grafts. Sinusoidal perfusion verocity derived from hepatic artery clamping examined anatomically, physiologically, and biochemically in the liver with or without macrovesicular fatty liver.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study.2014
Author(s)
Kudo A, Mogushi K, Takayama T, Matsumura S, Ban D, Irie T, Ochiai T, Nakamura N, Tanaka H, Anzai N, Sakamoto M, Tanaka S, Arii S.
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Journal Title
J Gastroenterol.
Volume: 49
Issue: 3
Pages: 502-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Morphological and microarray analyses of human hepatocytes from xenogeneic host livers.2013
Author(s)
Tateno C, Miya F, Wake K, Kataoka M, Ishida Y, Yamasaki C, Yanagi A, Kakuni M, Wisse E, Verheyen F, Inoue K, Sato K, Kudo A, Arii S, Itamoto T, Asahara T, Tsunoda T, Yoshizato K.
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Journal Title
Laboratory investigation
Volume: 93
Issue: 1
Pages: 54-71
DOI
Related Report
Peer Reviewed
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[Presentation] 術後肝不全予測因子の検討.2014
Author(s)
古山 貴基, 工藤 篤, 上田 浩樹, 大畠 慶映, 佐藤 拓, 赤星 径一, 中尾 圭介, 伊藤 浩光, 勝田 絵里子, 松永 浩子, 三浦 智也, 松村 聡, 伴 大輔, 落合 高徳, 入江 工, 中村 典明, 田中 真二, 田邉 稔.
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
京都
Year and Date
2014-04-04
Related Report
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[Presentation] Non-B Non-C肝癌における代謝関連因子の臨床病理学的および分子生物学的解析.2014
Author(s)
赤星 径一, 松村 聡, 田中 真二, 上田 浩樹, 佐藤 拓, 大畠 慶映, 中尾 圭介, 古山 貴基, 勝田 絵里子, 松永 浩子, 伊藤 浩光, 三浦 智也, 伴 大輔, 落合 高徳, 入江 工, 工藤 篤, 中村 典明, 田邉 稔.
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
京都
Year and Date
2014-04-03
Related Report
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