Developmemt of novel psychosocial evaluation method in liver transplantation for alcohol liver failure

• Project/Area Number: 24591875
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya University
• Principal Investigator: Onishi Yasuharu 名古屋大学, 医学部附属病院, 病院助教 (60377257)
• Co-Investigator(Kenkyū-buntansha): 木内 哲也 名古屋大学, 医学系研究科, 教授(移行) (40303820) ; 小倉 靖弘 名古屋大学, 医学部附属病院, 病院教授 (20335251) ; 亀井 秀弥 名古屋大学, 医学部附属病院, 病院助教 (80422773) ; 木村 宏之 名古屋大学, 医学系研究科, 講師 (50378030)
• Project Period (FY): 2012-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: アルコール性肝不全 / 肝移植 / 心理社会的適応評価 / 心理社会的適応基準 / 肝移植適応評価

Outline of Final Research Achievements

Recipients' re-drinking in 20-50% after liver transplantation for alcoholic liver failure is a social problem that could negate transplanted organs provided free of donor. Psychosocial evaluation and long-term follow-up from the preoperative point of view are also important worldwide.
We created psychosocial criteria and compared retrospectively with "candidate for transplant recipients for alcoholic liver failure" and "candidate for other liver transplant recipients" to investigate the comprehensive factors. We have been conducting retrospective examination using psychosocial evaluation criteria established at our hospital, and we have clarified the effectiveness of this evaluation method so far at the conference.

Research Products

• [Journal Article] Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease. (2017)
  • Author(s): Kimura H, Onishi Y, Kishi S, Kurata N, Ogiso S, Kamei H, Tsuboi C, Yamaguchi N, Shiga A, Kondo M, Yokoyama Y, Takasato F, Fujishiro H, Ishizuka K, Okada T, Ogura Y, Ozaki N.
  • Journal Title: Am J Case Rep Volume: 18 Pages: 1215-1219
  • DOI: 10.12659/ajcr.906446
  • Peer Reviewed / Open Access
• [Journal Article] Risk of alcohol use relapse after liver transplantation for alcoholic liver disease (2017)
  • Author(s): Yasuharu Onishi, Hiroyuki Kimura, Tomohide Hori, Shinichi Kishi, Hideya Kamei, Nobuhiko Kurata, Chisato Tsuboi, Naoko Yamaguchi, Mayu Takahashi, Saki Sunada, Mitsuaki Hirano, Hiroshige Fujishiro, Takashi Okada, Masatoshi Ishigami, Hidemi Goto, Norio Ozaki, Yasuhiro Ogura
  • Journal Title: World Journal of Gastroenterology Volume: 23 Issue: 5 Pages: 869-875
  • DOI: 10.3748/wjg.v23.i5.869
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Successful Blood Transfusion Management of a Living Donor Liver Transplant Recipient in the Presence of Anti-Jra: A Case Report. (2017)
  • Author(s): Kurata N, Onishi Y, Kamei H, Hori T, Komagome M, Kato C, Matsushita T, Ogura Y
  • Journal Title: Transplant Proc Volume: 49 Issue: 7 Pages: 1604-1607
  • DOI: 10.1016/j.transproceed.2017.06.009
  • Peer Reviewed
• [Journal Article] Donor Selection and Prophylactic Strategy for Venous Thromboembolic Events in Living Donors of Liver Transplantation Based on Results of Thrombophilia Screening Tests. (2017)
  • Author(s): Kamei H, Onishi Y, Kurata N, Ishigami M, Ogura Y.
  • Journal Title: Ann Transplant Volume: 22 Pages: 409-416
  • Peer Reviewed
• [Journal Article] Changes in Muscle Strength and Six-Minute Walk Distance Before and After Living Donor Liver Transplantation. (2016)
  • Author(s): Mizuno Y, Ito S, Hattori K, Nagaya M, Inoue T, Nishida Y, Onishi Y, Kamei H, Kurata N, Hasegawa Y, Ogura Y
  • Journal Title: Transplant Proc Volume: 48(10) Issue: 10 Pages: 3348-3355
  • DOI: 10.1016/j.transproceed.2016.08.042
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of extensive inferior vena cava thrombosis due to the ligation of a large mesenteric-caval shunt during liver transplantation: A case report. (2016)
  • Author(s): Kamei H, Onishi Y, Ishigami M, Ishizu Y, Suzuki K, Ogura Y.
  • Journal Title: Int J Surg Case Rep Volume: 29 Pages: 211-214
  • DOI: 10.1016/j.ijscr.2016.11.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation. (2016)
  • Author(s): Hori T, Onishi Y, Kamei H, Kurata N, Ishigami M, Ishizu Y, Ogura Y.
  • Journal Title: Ann Gastroenterol Volume: 29(4) Pages: 454-459
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation. (2016)
  • Author(s): Hori T, Ogura Y, Onishi Y, Kamei H, Kurata N, Kainuma M, Takahashi H, Suzuki S, Ichikawa T, Mizuno S, Aoyama T, Ishida Y, Hirai T, Hayashi T, Hasegawa K, Takeichi H, Ota A, Kodera Y, Sugimoto H, Iida T, Yagi S, Taniguchi K, Uemoto S.
  • Journal Title: World J Hepatol Volume: 8(25) Issue: 25 Pages: 1047-1060
  • DOI: 10.4254/wjh.v8.i25.1047
  • NAID: 120006345026
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fibrosing Cholestatic Hepatitis in a Complicated Case of an Adult Recipient After Liver Transplantation: Diagnostic Findings and Therapeutic Dilemma. (2016)
  • Author(s): Hori T, Onishi Y, Kamei H, Kurata N, Ishigami M, Ishizu Y, Ogura Y.
  • Journal Title: Am J Case Rep Volume: 17 Pages: 597-604
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Postoperative psychiatric complications in living liver donors (2015)
  • Author(s): Hiroyuki Kimura、Yasuharu Onishi、Saki Sunada、Shinichi Kishi、Nobuyuki Suzuki、Chisato Tsuboi、Naoko Yamaguchi、Hisashi Imai、 Hideya Kamei、Satoshi Fujisiro、Takashi Okada、Masatoshi Ishigami、Yasuhiro Ogura、Tetsuya Kiuchi、Norio Ozaki
  • Journal Title: Transplant Proc Volume: 47 Issue: 6 Pages: 1860-1865
  • DOI: 10.1016/j.transproceed.2015.06.021
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 肝移植レシピエントにおける術後の精神医学的合併症についてー精神科リエゾンの活動を通してー (2017)
  • Author(s): 近藤麻衣、岸辰一、藤城弘樹、木村宏之、岡田俊、尾崎紀夫、川口高明、高橋真悠、坪井千里、山口尚子、小倉靖弘、大西康晴、亀井秀弥、駒込昌彦、倉田信彦
  • Organizer: 第35回日本肝移植研究会
• [Presentation] 心理社会的視点からみたアルコール性肝不全に対する肝移植治療 (2016)
  • Author(s): 大西康晴 木村宏之 坪井千里 山口尚子 倉田信彦 亀井秀弥 岸辰一 藤城弘樹 尾崎紀夫 小倉靖弘
  • Organizer: 第５２回日本移植学会総会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都港区)
  • Year and Date: 2016-09-29
• [Presentation] アルコール性肝不全に対する肝移植治療：心理社会的な視点から (2015)
  • Author(s): 大西康晴、木村宏之、坪井千里、山口尚子、倉田信彦、堀智英、亀井秀弥 藤城弘樹、尾崎紀夫、小倉靖弘
  • Organizer: 平成２７年度 アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 兵庫県神戸市（神戸国際会議場）
  • Year and Date: 2015-10-11
• [Presentation] 劇症肝炎に対する脳死肝移植登録症例の検討 (2014)
  • Author(s): 大西康晴
  • Organizer: 第50回日本移植学会総会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] 当院における劇症肝炎に対する肝移植の検討 (2014)
  • Author(s): 大西康晴
  • Organizer: 第69回日本消化器外科学会総会
  • Place of Presentation: ホテルハマツ（福島県郡山市）
  • Year and Date: 2014-07-16 – 2014-07-18
• [Presentation] 劇症肝炎にて脳死登録された症例の治療と転帰―改正臓器移植法前後の検討を中心に (2014)
  • Author(s): 大西康晴
  • Organizer: 第32回日本肝移植研究会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-03 – 2014-07-05
• [Presentation] 当院における劇症肝炎に対する肝移植の検討 (2014)
  • Author(s): 大西康晴
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 国立京都国際会館(京都府京都市）
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] アルコール性肝不全の肝移植適応 Sobriety(6-months rule)と Recidivism (2014)
  • Author(s): 木村宏之
  • Organizer: 第10回伊豆肝臓カンファレンス
  • Place of Presentation: 淡島ホテル（沼津市）
• [Presentation] アルコール性肝不全に対する肝移植治療：心理社会的適応基準の確立を目指して (2013)
  • Author(s): 大西康晴
  • Organizer: 第113回 日本外科学会定期学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
• [Presentation] アルコール性肝硬変の肝移植における心理社会的適応基準 (2013)
  • Author(s): 大西康晴
  • Organizer: 第31回 日本肝移植研究会
  • Place of Presentation: 熊本全日空ホテル（熊本市）
• [Presentation] アルコール性肝疾患に対する肝移植の新しい心理社会的適応基準 (2013)
  • Author(s): 大西康晴
  • Organizer: 第49回 日本移植学会
  • Place of Presentation: 京都国際会館（京都市）