• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of air way xenotransplant graft with extracellular matrix and cytokine

Research Project

Project/Area Number 24591881
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKagawa University

Principal Investigator

GO TETSUHIKO  香川大学, 医学部附属病院, 講師 (50313656)

Co-Investigator(Kenkyū-buntansha) MATSUURA Natsumi  香川大学医学部, 附属病院, 助教 (20572853)
KASAI Yoshitaka  香川大学医学部, 附属病院, 助教 (40610085)
YOKOMISE Hiroyasu  香川大学, 医学部, 教授 (80231728)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords再生医学 / 気道再建 / 異種移植 / 人工材料 / 再生医療 / 人工臓器 / 人口臓器
Outline of Final Research Achievements

We investigated the novel tissue material for airway repair. Pig trachea was decellularised by detergent - enzymatic method treatment into extracellular matrix (ECM) which was confirmed non-antigenicity. Patch material made from this ECM was applied as xenotransplant tissue graft to repair air way defect made on dog’s cervical trachea. ECM patch graft derived from pig was incorporated in heterologous host of dog without immunosuppression and air way defect was restored successfully. On the other hand, applying cytokines such as erythropoietin, G-CSF did not improve epithelialization on the ECM graft, which needs to be investigated further.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(2 results)

All 2013 Other

All Presentation (2 results)

  • [Presentation] 脱細胞化気管ECM (extra cellular matrix)の気道補填材料及び異種移植材料としての可能性について2013

    • Author(s)
      呉 哲彦
    • Organizer
      第30回日本呼吸器外科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 脱細胞化気管ECM(extra cellurar matrix)の気道補填材料及び異種移植材料としての可能性について

    • Author(s)
      呉 哲彦
    • Organizer
      第30回日本呼吸器外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi