Translational research for deceased donor liver transplantation

• Project/Area Number: 24591882
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Ehime University
• Principal Investigator: TAKADA Yasutsugu 愛媛大学, 医学(系)研究科(研究院), 教授 (10272197)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 肝移植 / 心停止ドナー / トランスレーショナル・リサーチ

Outline of Final Research Achievements

Use of liver grafts from donors after cardiac death (DCD) is one of the ways to attenuate the organ shortage in clinical liver transplantation (LT). To introduce the DCD-LT in Japan, we conducted a study of porcine LT using DCD as a translational research. As a results, porcine model of DCD-LT operation has been established. In addition, the efficacy of pharmacological graft protection has been suggested.

Research Products

• [Journal Article] Biological markers of hepatocellular carcinoma for use as selection criteria in liver transplantation. (2015)
  • Author(s): Takada Y, Tohyama T, Watanabe J
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 22 Pages: 279-286
  • Peer Reviewed / Open Access
• [Journal Article] Intestinal preconditioning ameliorates hepatic ischemia reperfusion injury in rats: Role of heme oxygenase-1 in the second-window of protection. (2015)
  • Author(s): Kageyama S, Hata K, Tanaka H, Hirao H, Kubota T, Okamura Y, Iwaisako K, Takada Y, Uemoto S.
  • Journal Title: Liver Transpl Volume: 21 Pages: 112-122
  • Peer Reviewed
• [Journal Article] Quantification of pancreatic stiffness on intraoperative ultrasound elastography and evaluation of its relationship with postoperative pancreatic fistula. (2015)
  • Author(s): Hatano M, Watanabe J, Kushihata F, Tohyama T, Kuroda T, Koizumi M, Kumagi T, Hisano Y, Sugita A, Takada Y.
  • Journal Title: Int Surgery Volume: 100 Pages: 497-502
  • Peer Reviewed
• [Journal Article] 肝中央2区域切除術 (2014)
  • Author(s): 藤山泰二、高田泰次
  • Journal Title: 消化器外科 Volume: 37 Pages: 752-756
  • Peer Reviewed
• [Journal Article] Randomized, multicenter trial comparing tacrolimus plus mycophenolate mofetil to tacrolimus plus steroid in hepatitis C virus-positive recipients of living donor liver transplantation. (2013)
  • Author(s): Takada Y, Kaido T, Asonuma K, Sakurai H, Kubo S, Kiuchi T, Inomata Y, Isaji S, Tsumura H, Teramukai S, Matsubara Y, Sakabayashi S, Uemoto S.
  • Journal Title: Liver Transplantation Volume: 19 Pages: 896-906
  • Peer Reviewed
• [Journal Article] Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation. (2013)
  • Author(s): Kamei H, Matsuda S, Nakamura T, Fujimoto Y, Oike F, Ogura Y, Takada Y, Hamajima N.
  • Journal Title: Transplant Immunology Volume: 28 Pages: 14-17
  • Peer Reviewed
• [Journal Article] Association of transporter associated with antigen processing (TAP) gene polymorphisms in donors with acute cellular rejection in living donor liver transplantation. (2013)
  • Author(s): Kamei H, Masuda S, Nakamura T, Oike F, Takada Y, Hamajima N.
  • Journal Title: Journal of Gastrointestinal Liver Diseases Volume: 22 Pages: 167-171
  • Peer Reviewed
• [Journal Article] Usefulness of the Kyoto criteria as expanded selection criteria for liver transplantation for hepatocellular carcinoma. (2013)
  • Author(s): Kaido T, Ogawa K, Mori A, Fujimoto Y, Ito T, Tomiyama K, Takada Y, Uemoto S.
  • Journal Title: Surgery Volume: 154 Pages: 1053-1060
  • Peer Reviewed
• [Journal Article] Living donor liver transplantation for hepatitis C. (2013)
  • Author(s): Takada Y, Uemoto S.
  • Journal Title: Surg Today Volume: 2013 Jul43(7) Issue: 7 Pages: 709-714
  • DOI: 10.1007/s00595-012-0361-z
  • NAID: 10031183378
  • Peer Reviewed
• [Journal Article] Soft-light overhead illumination systems improve laparoscopic task performance. (2013)
  • Author(s): Takai A, Takada Y, Motomura H, Teramukai S.
  • Journal Title: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques Volume: in press
  • Peer Reviewed
• [Journal Article] Long-term quality of life of donors after living donor liver transplantation. (2012)
  • Author(s): Takada Y, Suzukamo Y, Oike F, Egawa H, Morita S, Fukuhara S, Uemoto S, Tanaka K.
  • Journal Title: Liver Transpl. Volume: 18 Issue: 11 Pages: 1343-1352
  • DOI: 10.1002/lt.23509
  • Peer Reviewed
• [Journal Article] Living donor liver transplantation for Budd-Chiari syndrome with hepatic inferior vena cava obstruction after open pericardial procedures. (2012)
  • Author(s): Fukuda A, Ogura Y, Kanazawa H, Mori K, Kawaguchi M, Takada Y, Uemoto S.
  • Journal Title: Surg Today Volume: Nov28 Issue: 10 Pages: 1180-1184
  • DOI: 10.1007/s00595-012-0440-1
  • NAID: 10031201395
  • Peer Reviewed
• [Presentation] Liver transplantation for hepatocellular carcinoma- Biological markers for selectioncriteria. (2014)
  • Author(s): Takada Y
  • Organizer: 24th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-12-05 – 2014-12-07
  • Invited
• [Presentation] Multicenter study based on the Japanese liver transplantation registry. (2014)
  • Author(s): Takada Y
  • Organizer: The 1st International Congress of Living Donor Liver Transplantation Study Group.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-11-07 – 2014-11-08
  • Invited
• [Presentation] The clinical course of preoperative anti-HLA antibody-positive rwcipients after liver transplantation. (2014)
  • Author(s): Tohyama T, Watanabe J, Hatano M, Ito E, Inoue H, Kageyama S, Takai A, Mizumoto T, Kushihata F, Takada Y
  • Organizer: The 2014 Joint International Congress of ILTS, ELITA & LICAGE
  • Place of Presentation: London, UK
  • Year and Date: 2014-06-04 – 2014-06-07
• [Presentation] Long-term course of five patients who underwent liver transplantation with small-for-size grafts with a hemi-portocaval shunt. (2014)
  • Author(s): Ito E, Tohyama T, Watanabe J, Hatano M, Inoue H, Kageyama S, Mizumoto T, Takai A, Kushihata F, Takada Y
  • Organizer: The 2014 Joint International Congress of ILTS, ELITA & LICAGE
  • Place of Presentation: London, UK
  • Year and Date: 2014-06-04 – 2014-06-07
• [Presentation] Optimal criteria for HCC in liver transplantation. (2013)
  • Author(s): Takada Y.
  • Organizer: Congress of Asian Society of Transplantation 2013
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] Risk factors for long term health-related QOL of donors after living donor liver transplantation. (2013)
  • Author(s): Takada Y.
  • Organizer: 23rd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
  • Place of Presentation: Bucharest, Romania
  • Invited
• [Presentation] 生体肝移植におけるsmall-for-size graft (2012)
  • Author(s): 高田泰次
  • Organizer: 第１１２回日本外科学会定期学術集会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] Small-for-Size Graft Syndrome in Liver Transplantation. (2012)
  • Author(s): Takada Y
  • Organizer: World Congress of the International Association of Surgeons, Gastroenterologists, and Oncologists (IASGO).
  • Place of Presentation: Bangkok, Thailand
  • Invited
• [Presentation] Strategies for Recurrence of Hepatitis C after Living Donor Liver Transplantation. (2012)
  • Author(s): Takada Y
  • Organizer: World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
  • Place of Presentation: Bangkok, Thailand
  • Invited
• [Presentation] Long Term Follow-Up of Donors’ Quality of Life after Living Donor Liver Transplantation. (2012)
  • Author(s): Takada Y, Suzukamo Y, Fukuhara S, Uemoto S, Tanaka K.
  • Organizer: 24Th International Congress of The Transplantation Society
  • Place of Presentation: Berlin, Germany
• [Presentation] Randomized Trial Comparing Tacrolimus And Steroid With Tacrolimus And Mycophenolate Mofetil Among HCV Positive Recipients In Living Donor Liver Transplantation. (2012)
  • Author(s): Yasutsugu Takada, Toshimi Kaido, Katsuhiro Asonuma, Hiroyuki Sakurai, Shoji Kubo, Tetsuya Kiuchi, Yukihiro Inomata, Shuji Isaji, Shinji Uemoto.
  • Organizer: The 2012 (18th) Joint international congress of ILTS（International Liver Transplantation Society）, ELITA, LICAGE
  • Place of Presentation: San Francisco, USA
• [Book] 肝移植医療における臨床検査の役割、「検査診断学への展望―臨床検査指針：測定とデータ判読のポイント－」 (2013)
  • Author(s): 藤山泰二、渡邊常太、高田泰次
  • Publisher: 南江堂