Development of hybrid neo-islet tissue using cell-sheet technology
| Project/Area Number |
24591885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Takahiro 福島県立医科大学, 医学部, 博士研究員 (00566812)
YAMASHITA Michitoshi 福島県立医科大学, 医学部, 助教 (20381387)
ISHII Shou 福島県立医科大学, 医学部, 助教 (40468129)
ISE Kazuya 福島県立医科大学, 医学部, 講師 (90363746)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 1型糖尿病 / 膵島移植 / 細胞シート / 血管新生 / 膵島再生 |
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| Outline of Final Research Achievements |
The aim of this study is to fabricate of islet cell sheet using porcine islets and to laminate endothelial cells and pancreatic ductal cells with islet cells in order to develop the blood supply and the islet function in the transplantation sites. The islet cell sheets of porcine islets were fabricated by using the temperature-responsive culture dishes. The endothelial cells sheets were laminated with islet cells, and the hybrid tissue was transplanted into the subcutaneous space of the diabetic mice without any complication. It was impossible to isolate the pancreatic ductal cells from pancreas. This study indicated that the fabrication of multi-layered islet cell sheets could result in further development of the therapeutic effect for diabetic mellitus.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Mizoribine as Sole Immunosuppressive Agent in Islet Xenotransplantation Models: A Candidate Immunosuppressant Causing no Adverse Effects on Islets.2012
Author(s)
Yamashita M, Saito T, Ise K, Ishii S, Satoh Y, Saito T, Oshibe I, Shimizu H, Kenjo A, Kimura T, Gotoh M.
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Journal Title
Cell Transplantation
Volume: 21(2-3)
Issue: 2-3
Pages: 535-545
DOI
Related Report
Peer Reviewed
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