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EFFICACY AND SAFETY OF T CELLS WITH CEA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR CANCER IMMUNOTHERAPY

Research Project

Project/Area Number 24591899
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionMie University

Principal Investigator

WANG Linan  三重大学, 医学(系)研究科(研究院), 特任助教(研究担当) (00589484)

Co-Investigator(Kenkyū-buntansha) KATO Takuma  三重大学, 大学院医学系研究科, 准教授 (60224515)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCEA-Tgマウス / CAR-T細胞 / キメラ抗原受容体 / 胎児性癌抗原 / T細胞受容体 / GITR / がん治療 / 複刺激シグナル分子 / 癌胎児性抗原
Outline of Final Research Achievements

(1)Retrovirus vector composed of anti-CEA scFV and signaling domain of human or mouse CD3 and CD28 successfully transduced human or mouse T cells, respectively, to express functional CAR.(2) Adoptive therapy with CEA-specific CAR expressing human T cells to tumor bearing lymphopenic NOG mouse inhibited growth of CEA positive, but not CEA negative, tumor. (3) Likewise, adoptive therapy with CEA-specific CAR expressing mouse T cells to tumor bearing lymphoreplete CEA-Tg mouse inhibited growth of CEA-positive tumor only when the mouse received lymphodepleting preconditioning. (4) However, this tumor growth inhibition was associated with inflammation in lungs in a manner independent of CAR-specificity and severe weight loss in a manner dependent of CAR-specificity. (5) CEA-specific CAR-T cells induce systemic cytokine response that could induce anorexia in CEA-Tg. (6) CEA-specific CAR-T cells induce malnutrition in CEA-Tg.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] 癌胎児性抗原を標的としたキメラ抗原受容体導入T細胞輸注療法の有効性と安全性の検討2013

    • Author(s)
      王 立楠
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      山口
    • Related Report
      2013 Research-status Report
  • [Presentation] Efficacy and safety of T cells with CEA specific chimeric antigen receptor for cancer immunotherapy2013

    • Author(s)
      王 立楠
    • Organizer
      日本癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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