Study for molecular basis of trastuzumab-resistance and the development of novel therapeutic strategies.
| Project/Area Number |
24591901
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kansai Medical University (2013-2014)
Kyoto University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Eiji 京都大学, 医学研究科, 助教 (00612897)
SATO Fumiaki 京都大学, 医学研究科, 准教授 (20467426)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 乳癌 / HER2 / トラスツズマブ / 耐性 / ＡＤＣＣ / ADCC / トラスツズマブ耐性 |
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| Outline of Final Research Achievements |
HER2-targeted therapy using trastuzumab has dramatically improved the prognosis of HER2-positive breast cancer. However, it becomes the important clinical issue how to overcome tastuzumab-resistant breast cancer. In this study, we addressed the molecular mechanism for acquired resistance to trastuzumab which can activate antibody dependent cell mediated cytotoxicity (ADCC). Gene expressing profile using ADCC-resistant breast cancer cell line showed that vacuolar type ATPase (vATPase) which drives active membrane transport was associated with ADCC-resistance. ATP6V1B1 gene coding subunit B1 might be specifically responsible for acquired resistance in terms of perforin/granzyme pathway.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Effects of zoledronic acid and the association between its efficacy and \gamma\delta T cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol2014
Author(s)
Sumi E, Sugie T, Yoshimura K, Tada H, Ikeda T, Suzuki E, Tanaka Y, Teramukai S, Shimizu A, Toi M, Minato N
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Journal Title
Journal of Translational Medicine
Volume: 12
Issue: 1
Pages: 310-310
DOI
Related Report
Peer Reviewed / Open Access
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