Management of breast cancer patients with BRCA1 or BRCA2 mutations.
| Project/Area Number |
24591903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka University |
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Principal Investigator |
SHIMOMURA Atsushi 大阪大学, 医学(系)研究科(研究院), 助教 (10625841)
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| Co-Investigator(Kenkyū-buntansha) |
KIM Seung JIN 大阪大学, 医学系研究科, 准教授 (90346213)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 乳癌 / 家族性乳癌 / BRCA1 / BRCA2 / 変異保因者 |
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| Outline of Final Research Achievements |
1. Four breast cancer patients with family history screened with HBOC, one BRCA1 mutation and two BRCA2 mutations were identified. Two of three pateints underwent risk-reducing salpingo-oophorectomy (RRSO) during surveillance program for HBOC. 2. We showed that a significant proportion of patients with BRCA1-methylated tumors harbored BRCA1 promoter methylation in normal breast tissues but those with BRCA1-unmethylated tumors did not. This suggests a possibility that a small proportion of the epithelial cells with BRCA1 promoter methylation can be precursor cells from which BRCA1-methylated breast tumors originate.
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Report
(4 results)
Research Products
(2 results)
