Management of breast cancer patients with BRCA1 or BRCA2 mutations.

Research Project

Project/Area Number	24591903
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	General surgery
Research Institution	Osaka University
Principal Investigator	SHIMOMURA Atsushi 大阪大学, 医学(系)研究科(研究院), 助教 (10625841)
Co-Investigator(Kenkyū-buntansha)	KIM Seung JIN 大阪大学, 医学系研究科, 准教授 (90346213)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	乳癌 / 家族性乳癌 / BRCA1 / BRCA2 / 変異保因者
Outline of Final Research Achievements	1. Four breast cancer patients with family history screened with HBOC, one BRCA1 mutation and two BRCA2 mutations were identified. Two of three pateints underwent risk-reducing salpingo-oophorectomy (RRSO) during surveillance program for HBOC. 2. We showed that a significant proportion of patients with BRCA1-methylated tumors harbored BRCA1 promoter methylation in normal breast tissues but those with BRCA1-unmethylated tumors did not. This suggests a possibility that a small proportion of the epithelial cells with BRCA1 promoter methylation can be precursor cells from which BRCA1-methylated breast tumors originate.