Direct target genes of miRNAs involved in lung cancer
| Project/Area Number |
24591905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
Ouchida Mamoru 岡山大学, 医歯(薬)学総合研究科, 准教授 (80213635)
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| Co-Investigator(Kenkyū-buntansha) |
OKA Takashi 岡山大学, 大学院医歯薬学総合研究科, 助教 (50160651)
ITO Sachio 岡山大学, 大学院医歯薬学総合研究科, 助教 (30335624)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | microRNA / 標的遺伝子 / 肺癌 / miRNA / 肺がん |
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| Outline of Final Research Achievements |
Lately, miR-17-92, which is highly expressed in malignant lung cancer cells, is considered the key miRNA for tumorigenesis. However, its direct targets remain under reported. We identified the FOXP1, TP53INP1, TNFAIP3, and TUSC2 genes as miR-19a targets, using luciferase, pull-down, and western blot assays. The four miR-19a target cDNA expression vectors suppressed cell viability, colony formation, migration, and invasion of lung cancer cells.
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Report
(5 results)
Research Products
(15 results)
