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The development of the system estimating realtime antitumor activity of activated T lymphocytes in cancer immunotherapy

Research Project

Project/Area Number 24591908
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKyushu University

Principal Investigator

MORISAKI Takashi  九州大学, 医学(系)研究科(研究院), 共同研究員 (90291517)

Co-Investigator(Kenkyū-buntansha) ONISHI Hideya  九州大学, 大学院医学研究院, 准教授 (30553276)
KATANO Mitsuo  九州大学, 大学院医学研究院, 教授 (10145203)
IMAIZUMI Akira  九州大学, 大学院医学研究院, 共同研究員 (30624051)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsrandom migration / 運動能 / 活性化リンパ球 / 細胞障害活性 / バイオマーカー / 治療効果予測 / FTYP / 癌細胞障害活性 / 治療効果 / 患者予後 / がん / 免疫療法 / リアルタイム評価システム / 定量的評価 / 抗腫瘍活性 / リンパ球 / 樹状細胞 / ベッドサイド
Outline of Final Research Achievements

In activated T lymphocytes, velocity of random migration increases than resting lymphocytes and it may contribute to cytotoxicity against cancer. Addition of phosphorylated FTY720 (FTYP) suppresses the velocity of random migration in activated T lymphocytes and it leads to the decrease in cytotoxicity against cancer. In addition, we confirmed tha antitumor effect by the administration of FTYP using in vivo mice model. These results suggest that random migration in activated T lymphocytes may become a useful biomarker for therapeutic effect of cancer immunotherapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) Remarks (3 results)

  • [Journal Article] Random Migration Contributes to Cytotoxicity of Activated CD8+ T-Lymphocytes but not NK cells.2014

    • Author(s)
      Onishi H, Kiyota A, Koya N, Tanaka H, Umebayashi M, Katano M, Morisaki T
    • Journal Title

      Anticancer Res

      Volume: 34(8) Pages: 3947-3956

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An epithelial cell adhesion molecule- and CD3 bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro.2014

    • Author(s)
      Umebayashi M, Kiyota A, Koya N, Tanaka H, Onishi H, Katano M, Morisaki T
    • Journal Title

      Anticancer Res

      Volume: 34(8) Pages: 4509-4520

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] NKG2D-directed cytokine-activated killer lymphocyte therapy combined with gemcitabine for patients with chemoresistant metastatic solid tumors.2014

    • Author(s)
      Morisaki T, Hirano T, Koya N, Kiyota A, Tanaka H, Umebayashi M, Onishi H, Katano M
    • Journal Title

      Anticancer Res

      Volume: 34(8) Pages: 4529-4538

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Hedgehog inhibitor cyclopamine impairs the benefits of immunotherapy with activated T and NK lymphocytes derived from patients with advanced cancer.2013

    • Author(s)
      Onishi H, Morisaki T, Kiyota A, Koya N, Tanaka H, Umebayashi M, Katano M
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: 62(6) Issue: 6 Pages: 1029-1039

    • DOI

      10.1007/s00262-013-1419-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Hedgehog inhibitor suppresses the function of monocyte-derived dendritic cells from patients with advanced cancer under hypoxia.2013

    • Author(s)
      Onishi H, Morisaki T, Kiyota A, Koya N, Tanaka H, Umebayashi M, Katano M
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 436(1) Issue: 1 Pages: 53-59

    • DOI

      10.1016/j.bbrc.2013.05.057

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new method for rapid cytotoxic T-lymphocyte induction using a multiple cytokine.2012

    • Author(s)
      Onishi H, Katano M, Morisaki T et al.
    • Journal Title

      Anticancer Research

      Volume: 32(6) Pages: 2385-2390

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combining cetuximab with killer lymphocytes synergistically inhibits human.2012

    • Author(s)
      Morisaki T, Onishi H, Katano M et al.
    • Journal Title

      Anticancer Research

      Volume: 32(6) Pages: 2249-2256

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cancer immunotherapy using NKG2D and DNAM-1 systems.2012

    • Author(s)
      Morisaki T, Onishi H, Katano M
    • Journal Title

      Anticancer Research

      Volume: 32(6) Pages: 2241-2247

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 個別化免疫細胞療法確立への試み2014

    • Author(s)
      大西 秀哉、森崎 隆、梅林 雅代、古屋 雄大、田中 裕人、清田 章文、片野 光男
    • Organizer
      第35回癌免疫外科研究会
    • Place of Presentation
      シェラトン都ホテル大阪(大阪府・大阪市)
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 免疫細胞療法テーラーメード化確立への試み2013

    • Author(s)
      大西 秀哉、森崎 隆、梅林 雅代、古屋 雄大、田中 裕人、清田 章文、片野 光男
    • Organizer
      第38回日本外科系連合学会
    • Place of Presentation
      ハイアットリージェンシー東京(東京都新宿区)
    • Related Report
      2013 Research-status Report
  • [Presentation] 制御性T細胞を標的としたテーラーメード消化器癌免疫療法2013

    • Author(s)
      大西 秀哉、森崎 隆、片野 光男
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      サンホテルフェニックス(宮崎市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Hedgehogシグナル阻害剤は活性化リンパ球療法の効果を減弱する2013

    • Author(s)
      大西 秀哉、森崎 隆、清田 章文、梅林 雅代、古屋 雄大、田中 裕人、片野 光男
    • Organizer
      第26回日本バイオセラピィ学会
    • Place of Presentation
      いわて県民情報交流センターアイーナ(盛岡市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ジェムザール併用活性化リンパ球の臨床効果とそのメカニズムの検討

    • Author(s)
      森崎 隆、清田 章文、田中 裕人、梅林 雅代、古屋 雄大、大西 秀哉、片野 光男
    • Organizer
      第17回バイオ治療法研究会
    • Place of Presentation
      福岡大学病院・福大メディカルセンター(福岡市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 樹状細胞(DCs)による制御性T細胞誘導の抑制を目的としたIDO阻害/DCワクチン併用療法の可能性

    • Author(s)
      荻野 利達
    • Organizer
      第112回 日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 低酸素環境で分化した樹状細胞(DCs)による制御性T細胞誘導にIDOが関与する

    • Author(s)
      大西 秀哉
    • Organizer
      第22回 日本樹状細胞研究会
    • Place of Presentation
      福島ビューホテル(福島市)
    • Related Report
      2012 Research-status Report
  • [Presentation] K-Ras変異癌に対するCetuximab併用免疫細胞療法の可能性

    • Author(s)
      古屋 雄大
    • Organizer
      第25回 日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      倉敷市芸文館(倉敷市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 個別化(テ-ラーメード)癌免疫細胞療法と地域医療

    • Author(s)
      森崎 隆
    • Organizer
      第5回 福岡県医学会総会
    • Place of Presentation
      福岡県医師会館(福岡市)
    • Related Report
      2012 Research-status Report
  • [Remarks] 九州大学大学院医学研究院 腫瘍制御学分野ホームページ

    • URL

      http://www.tumor.med.kyushu-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 九州大学大学院医学研究院 腫瘍制御学分野ホームページ

    • URL

      http://www.tumor.med.kyushu-u.ac.jp/

    • Related Report
      2013 Research-status Report
  • [Remarks] http://www.tumor.med.kyushu-u.ac.jp/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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