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Study on development of intermittent pneumatic compression according to severity of peripheral lymphedema

Research Project

Project/Area Number 24591914
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionYokohama City University

Principal Investigator

MAEGAWA Jiro  横浜市立大学, 医学(系)研究科(研究院), 教授 (70244449)

Co-Investigator(Kenkyū-buntansha) YABUKI Yuuichiro  横浜市立大学, 医学研究科, 客員研究員 (30610357)
YASUMURA Kazunori  横浜市立大学, 附属病院, 助教 (40351621)
TOMOEDA Hiroto  横浜市立大学, 医学研究科, 客員研究員 (40423553)
HIROTOMI Kouichi  横浜市立大学, 附属病院, 助教 (90368324)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsリンパ浮腫 / 空気圧マッサージ / 圧測定 / リンパマッサージ / 蛍光リンパ造影
Outline of Final Research Achievements

The aim of this study was to evaluate effectiveness of superficial lymph flow by intermittent pneumatic compression of 6 chambers with various modes for inflation and deflation using fluorescence lymphography. Suitable shape of a boot was also examined. Lymph flow was evaluated by analysis of intensity using a soft ware because lymph flow can be approximate to intensity changes. We observed steep intensity changes by alternate deflation mode from the thigh to the foot in healthy persons. This mode of deflation was applied for a patent. We applied the same study to secondary lymphedema patients and intensity was steeper in inflation-mode of regular order from the foot to the thigh. We also observed intensity was more gradual in severe lymphedema patients, which suggests strong compression may be necessary to accelerate lymph flow in sever lymph edema patients. The boot that can compress the dorsum of the foot was effective to accelerate lymph flow.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (26 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (19 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] 末梢動脈・静脈・リンパ管の病気update リンパ浮腫の病態と治療2013

    • Author(s)
      松原忍,前川二郎
    • Journal Title

      日本医師会雑誌

      Volume: 142 Pages: 1985-1988

    • Related Report
      2013 Research-status Report
  • [Journal Article] リンパ浮腫の臨床Up-To-Date リンパ浮腫の治療 圧迫療法2013

    • Author(s)
      松原忍,前川二郎
    • Journal Title

      Angiology Frontier

      Volume: 12 Pages: 122-129

    • Related Report
      2013 Research-status Report
  • [Journal Article] リンパ浮腫2013

    • Author(s)
      小川真里奈,矢吹雄一郎,門田優香,友枝裕人,廣冨浩一,安村和則,前川二郎
    • Journal Title

      成人病と生活習慣病

      Volume: 43 Pages: 568-573

    • Related Report
      2013 Research-status Report
  • [Journal Article] マイクロサージャリーにおける合併症とその対策 リンパ管静脈吻合2013

    • Author(s)
      北山晋也,前川二郎
    • Journal Title

      PEPERS

      Volume: 80 Pages: 47-53

    • Related Report
      2013 Research-status Report
  • [Journal Article] Outcomes of lymphaticovenous side-to-end anastomosis in peripheral lymphedema.2012

    • Author(s)
      Maegawa J, Yabuki, Y., Tomoeda,H, Hosono M,,Yasumura K.
    • Journal Title

      Journal of Vascular Surgery

      Volume: 55 Issue: 3 Pages: 753-760

    • DOI

      10.1016/j.jvs.2011.08.062

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Net Effect of Lymphaticovenous Anastomosis on Volume Reduction of Peripheral Lymphoedema after Complex Decongestive Physiotherapy2012

    • Author(s)
      Maegawa J, Hosono M, Tomoeda H, Tosaki A, Kobayashi S, Iwai T.
    • Journal Title

      European Journal of Vascular and Endvascular Surgery

      Volume: 43 Issue: 5 Pages: 602-608

    • DOI

      10.1016/j.ejvs.2011.12.032

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Study on real-time lymph flow in the lymph vessels of the lower limb by intermittent pneumatic compression in healthy volunteers and lymphedema patients2015

    • Author(s)
      Maegawa J,Kitayama S,Matsubara S,Mikami T,Tosaki A
    • Organizer
      41st European Society of Lymphology
    • Place of Presentation
      Lausanne, Sweitzerland
    • Year and Date
      2015-06-04 – 2015-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本リンパ学会 東京効果的にリンパドレナージを促す空気圧マッサージ器の開発(第二報)下肢リンパ浮腫患者における効果の検討2015

    • Author(s)
      北山晋也 篠木美穂 長谷川佳子 足立英子 鍵本慎太郎 廣富浩一 三上太郎 松原忍 前川二郎
    • Organizer
      第39回日本リンパ学会
    • Place of Presentation
      ソラシティーカンファレンスセンター(東京)
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ICG fluorescence lymphography reveals real-time lymph-flow in the superficial lymph-vessels of the lrg by intermittent pneumatic compression in healthy volunteers2014

    • Author(s)
      Maegawa J, Matsubara S, Kitayama S, Hirotomi K, Mikami T, Takagi N.
    • Organizer
      40th Congress of European Society of Lymphology
    • Place of Presentation
      Genova, Italy
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ICG fluorescence lymphography reveals real-time lymph-flow in the superficial lymph-vessels of the lrg by intermittent pneumatic compression in healthy volunteers2014

    • Author(s)
      Maegawa J, Matsubara S, Kitayama S, Hirotomi K, Mikami T, Takagi N.
    • Organizer
      15th Meeting of the European Venous Forum
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-06-26 – 2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 間歇的空気圧マッサージ器による表在リンパドレナージ効果の研究 第一報:ICG蛍光赤外リンパ造影による健常人のリンパ動態の検討2014

    • Author(s)
      前川二郎、松原忍、北山晋也、広富浩一、三上太郎、高木則和
    • Organizer
      第38回日本リンパ学会
    • Place of Presentation
      北里大学白金キャンパス(東京)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Outcomes of lymphativovenous side-to-end anastomosis and combined decongestive phystotherapy for treatment of breast cancer-related lymphedema2014

    • Author(s)
      Maegawa J,Kitayama S,Matsubara S,Hirotomi K,Mikami T,Tosaki A
    • Organizer
      63th European Society of Vascular Surgery
    • Place of Presentation
      Nice, France
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combination of combined decongestive physiotherapy and lymphaticovenous side-to-end anastomosis for treatment of breast cancer related lymphedema.2013

    • Author(s)
      Jiro Maegawa, Yuuichiro Yabuki, Hiroto Tomoeda
    • Organizer
      24th Congress of International Society of Lymphology
    • Place of Presentation
      Rome, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] Applications of SPECT-CT lymphoscintigraphy for lymphatico-microsurgery to evaluate lymphatic vessels in lower limb lymphedema.2013

    • Author(s)
      Jiro Maegawa, Yuuichiro Yabuki, Hiroto Tomoeda
    • Organizer
      24th Congress of International Society of Lymphology
    • Place of Presentation
      Rome, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] 四肢リンパ浮腫に対するリンパ管静脈側端吻合術の真の効果,2013

    • Author(s)
      前川二郎,矢吹雄一郎,友枝裕人,広富浩一,松原忍,戸崎綾子,松田奈菜絵,橋本紘吉
    • Organizer
      第37回日本リンパ学会
    • Place of Presentation
      アクロス福岡(福岡県)
    • Related Report
      2013 Research-status Report
  • [Presentation] リンパ浮腫最新の診断と治療,2013

    • Author(s)
      前川二郎
    • Organizer
      千葉大学形成外科医会
    • Place of Presentation
      京葉銀行文化プラザ(千葉県)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] リンパ浮腫の診断と治療 四肢リンパ浮腫の最新の画像診断と治療2013

    • Author(s)
      前川 二郎, 矢吹 雄一郎, 友枝 裕人, 広富 浩一, 安村 和則, 戸崎 綾子
    • Organizer
      日本静脈学会
    • Place of Presentation
      倉敷芸分館(岡山県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Outcomes of lymphaticovenous side-to-end anastomosis in patients with breast cancer related lymphedema.2013

    • Author(s)
      Jiro Maegawa, Yuuichiro Yabuki, Hiroto Tomoeda, Ayako Tosaki
    • Organizer
      39th Congress of European Society of Lymphology
    • Place of Presentation
      Valencia, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] Net effect of lymphaticovenous side-to-end anastomosis on volume reduction of peripheral lymphedema after complex decongestive physiotherapy2012

    • Author(s)
      Jiro Maegawa, Hiroto Tomoeda, Kouich Hirotomi, Kazunori Yasumura.,Yuuichiro Yabuki, Koukichi Hashimoto and Ayako Tosaki.
    • Organizer
      38th meeting of European Society of Lymphology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Research-status Report
  • [Presentation] 四肢リンパ浮腫に対するリンパ管静脈側端吻合術の真の体積減少効果と術後開存率についての検討2012

    • Author(s)
      前川二郎、矢吹雄一郎、友枝裕人、広富浩一、安村和則 , 戸崎綾子
    • Organizer
      第39回日本マイクロサージャリー学会
    • Place of Presentation
      北九州国際会議場(福岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] POSTOPERATIVE PATENCY RATES OF LYMPHATICOVENOUS SIDE-TO-END ANASTOMOSIS IN PERIPHERAL LYMPHEDEMA2012

    • Author(s)
      Jiro Maegawa, Yuichiro Yabuki, Hiroto Tomoeda, Misato Hosono, Kouichi Hirotomi, Kazunori Yasumura
    • Organizer
      4th Congress of the world union of the wound and healing society
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] リンパ浮腫の診断と治療-外科療法と保存療法の関係について-2012

    • Author(s)
      前川二郎
    • Organizer
      第32回日本静脈学会
    • Place of Presentation
      大宮ソニックシティー(埼玉県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 下肢慢性リンパ浮腫における弾性着衣を中心とする保存療法とリンパ管静脈吻合術の検討2012

    • Author(s)
      前川二郎、安村和則、広富浩一、細野味里、友枝裕人、矢吹雄一郎 、戸崎綾子
    • Organizer
      第55回日本形成外科学会総会
    • Place of Presentation
      ホテルニューオータニ(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 足がむくんでこまっています

    • Author(s)
      前川二郎
    • Organizer
      第25回健脚を血管病から守る公開シンポジウム
    • Place of Presentation
      はまぎんホール(神奈川県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] リンパ浮腫の診断と治療 -外科療法と保存療法の関係について-

    • Author(s)
      前川二郎
    • Organizer
      第33回石川県形成外科医会
    • Place of Presentation
      金沢都ホテル(石川県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Lymphedema: Presentation, Diagnosis, and Treatment2015

    • Author(s)
      Jiro Maegawa
    • Total Pages
      353
    • Publisher
      Springer International Publishing Switzerland
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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