Chemosensitivity test based on protein dynamics in response to anticancer drugs
| Project/Area Number |
24591917
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
KOEDA Keisuke 岩手医科大学, 医学部, 准教授 (10285596)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WAKABAYASHI Go 岩手医科大学, 医学部, 教授 (50175064)
NISHIZUKA Satoshi 岩手医科大学, 医学部, 講師 (50453311)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 抗癌剤感受性 / 抗癌剤耐性 / バイオマーカー / タンパク動態モニタリング |
|---|
| Outline of Final Research Achievements |
In the present study, we used "reverse-phase" protein array (RPPA) for profiling extremely small cell populations. This RPPA technology provides information on protein dynamics that occur prior to changing the phenotype in response to anticancer drugs. In practice, we were unable to collect enough samples from patients with peritonitis carcinomatosa; thus our study had more focused on establishment of the technology using cell lines. With respect to protein dynamics, the cellular proteins formed clusters that were regulated to degrade in synchronous manner in response to anticancer drugs regardless of the protein function. Moreover, drug-resistant populations expressed either stem- or epithelial-markers in mutually-exclusive manner, which exhibited very weak relationships to the stress induced by drugs.
|
Report
(4 results)
Research Products
(17 results)
-
[Journal Article] Hyperglycemia 3 days after esophageal cancer surgery is associated with an increased risk of postoperative infection.2014
Author(s)
Ito N, Iwaya T, Ikeda K, Kimura Y, Akiyama Y, Konosu M, Ishida K, Fujiwara H, Otsuka K, Nitta H, Kashiwaba M, Koeda K, Nishizuka S, Mizuno M, Sasaki A, Wakabayashi G.
-
Journal Title
J Gastrointest Surg.
Volume: 18
Issue: 9
Pages: 1547-1556
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers.2012
Author(s)
Ishida K, Nishiduka S, Chiba T, Ikeda M, Kume K, Endo F, Katagiri H, Matsuo T, Noda H, Iwaya T, Yamada N, Fujiwara H, Takahashi M, Itabashi T, Uesugi N,Maesawa C, Tamura G, Sugai T, Otsuka K, Koeda K, Wakabayashi G.
-
Journal Title
PLoS One
Volume: 7(8)
Issue: 8
Pages: e43236-e43236
DOI
Related Report
Peer Reviewed
-
-
-
[Presentation] 肥満胃がん症例における完全腹腔鏡下胃切除術の効果に関する検討2014
Author(s)
肥田 圭介, 藤原 久貴, 千葉 丈広, 西成 悠, 岩谷 岳, 木村 祐輔, 西塚 哲, 新田 浩幸, 大塚 幸喜, 佐々木 章, 若林 剛
Organizer
第12回日本消化器外科大会(JDDW2014)
Place of Presentation
神戸
Year and Date
2014-10-23 – 2014-10-25
Related Report
-
-
-
-
-
-
-
-
-
