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Chemosensitivity test based on protein dynamics in response to anticancer drugs

Research Project

Project/Area Number 24591917
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionIwate Medical University

Principal Investigator

KOEDA Keisuke  岩手医科大学, 医学部, 准教授 (10285596)

Co-Investigator(Kenkyū-buntansha) WAKABAYASHI Go  岩手医科大学, 医学部, 教授 (50175064)
NISHIZUKA Satoshi  岩手医科大学, 医学部, 講師 (50453311)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords抗癌剤感受性 / 抗癌剤耐性 / バイオマーカー / タンパク動態モニタリング
Outline of Final Research Achievements

In the present study, we used "reverse-phase" protein array (RPPA) for profiling extremely small cell populations. This RPPA technology provides information on protein dynamics that occur prior to changing the phenotype in response to anticancer drugs. In practice, we were unable to collect enough samples from patients with peritonitis carcinomatosa; thus our study had more focused on establishment of the technology using cell lines. With respect to protein dynamics, the cellular proteins formed clusters that were regulated to degrade in synchronous manner in response to anticancer drugs regardless of the protein function. Moreover, drug-resistant populations expressed either stem- or epithelial-markers in mutually-exclusive manner, which exhibited very weak relationships to the stress induced by drugs.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (12 results) (of which Invited: 3 results)

  • [Journal Article] Hyperglycemia 3 days after esophageal cancer surgery is associated with an increased risk of postoperative infection.2014

    • Author(s)
      Ito N, Iwaya T, Ikeda K, Kimura Y, Akiyama Y, Konosu M, Ishida K, Fujiwara H, Otsuka K, Nitta H, Kashiwaba M, Koeda K, Nishizuka S, Mizuno M, Sasaki A, Wakabayashi G.
    • Journal Title

      J Gastrointest Surg.

      Volume: 18 Issue: 9 Pages: 1547-1556

    • DOI

      10.1007/s11605-014-2587-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胃癌骨転移の臨床的特徴2014

    • Author(s)
      肥田圭介ほか
    • Journal Title

      日本臨床

      Volume: 72 Pages: 177-180

    • Related Report
      2013 Research-status Report
  • [Journal Article] A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines2014

    • Author(s)
      Endo et al.
    • Journal Title

      PLoS ONE

      Volume: 27

    • Related Report
      2013 Research-status Report
  • [Journal Article] Evaluation of chemosensitivity prediction using quantitative dose-response curve classification for highly advanced/relapsed gastric cancer2012

    • Author(s)
      Matsuo T, Nishizuka SS, Ishida S, Endo F, Katagiri H, Kume K, Ikeda M, Koeda K, Wakabayashi G
    • Journal Title

      World Journal of Surgical Oncology

      Volume: 11 Issue: 1 Pages: 11-11

    • DOI

      10.1186/1477-7819-11-11

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers.2012

    • Author(s)
      Ishida K, Nishiduka S, Chiba T, Ikeda M, Kume K, Endo F, Katagiri H, Matsuo T, Noda H, Iwaya T, Yamada N, Fujiwara H, Takahashi M, Itabashi T, Uesugi N,Maesawa C, Tamura G, Sugai T, Otsuka K, Koeda K, Wakabayashi G.
    • Journal Title

      PLoS One

      Volume: 7(8) Issue: 8 Pages: e43236-e43236

    • DOI

      10.1371/journal.pone.0043236

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Gastrointestinal endoscopy, education and accreditation in Japan2014

    • Author(s)
      Keisuke Koeda
    • Organizer
      The 66th annual congress of the Korean Surgical Society
    • Place of Presentation
      Seoul
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Proteomic Characterization of Drug-Tolerant Colonies for the Prevention of Peritonitis Carcinomatosa after Adjuvant Chemotherapy2014

    • Author(s)
      Satoshi Nishizuka
    • Organizer
      4TH GLOBAL REVERSE PHASE PROTEIN ARRAY WORKSHOP
    • Place of Presentation
      Paris
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 肥満胃がん症例における完全腹腔鏡下胃切除術の効果に関する検討2014

    • Author(s)
      肥田 圭介, 藤原 久貴, 千葉 丈広, 西成 悠, 岩谷 岳, 木村 祐輔, 西塚 哲, 新田 浩幸, 大塚 幸喜, 佐々木 章, 若林 剛
    • Organizer
      第12回日本消化器外科大会(JDDW2014)
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 5-FU不応性の腫瘍に対する治療戦略2014

    • Author(s)
      西塚 哲
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Daikenchuto (DKT) Helps Improve Postoperative Functional Disorder After Total Gastrectomy in Patients With Gastric Cancer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (JFMC42-1002)2014

    • Author(s)
      Koeda K et al.
    • Organizer
      DDW 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-05-03 – 2014-05-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃癌術後補助化学療法における5-FU効果予測因子としてのNF-κBの検討2013

    • Author(s)
      遠藤史隆, 西塚 哲, 石田和茂, 久米浩平, 片桐弘勝, 石田 馨, 岩谷 岳, 藤原久貴, 肥田圭介, 若林 剛
    • Organizer
      第85回日本胃癌学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 術後補助化学療法効果予測マーカーの同定とその生物学的意義の検証2012

    • Author(s)
      西塚 哲, 遠藤史隆, 石田和茂, 久米浩平, 片桐弘勝, 松尾鉄平, 大塚幸喜, 肥田圭介, 佐々木章, 若林 剛
    • Organizer
      第67回日本消化器外科学会
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report
  • [Presentation] Intracorporeal reconstruction after laparoscopic pylorus-preserving gastre ctomy: The new technique and initial experience

    • Author(s)
      Koeda, et al.
    • Organizer
      10th International Gastric Cancer Congress
    • Place of Presentation
      Verona
    • Related Report
      2013 Research-status Report
  • [Presentation] A phase II Study of new combination regimen with trastuzumab, S-1 and CDDP in HER2-positive advanced gastric cancer; OGSG1101, HGCSG1102, T-Core1101 Intergroup study (HERBIS-1 trial)

    • Author(s)
      Koeda, et al.
    • Organizer
      American Society for Clinical Oncology 2013
    • Place of Presentation
      Chicago
    • Related Report
      2013 Research-status Report
  • [Presentation] 腹腔鏡下胃切除術の地域における普及と教育ー胃がん治療の地域均てん化を目指し てー

    • Author(s)
      肥田圭介ほか
    • Organizer
      第26回日本内視鏡外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 腹腔鏡下幽門保存胃切除における鏡視下再建術の工夫

    • Author(s)
      肥田圭介ほか
    • Organizer
      第75回日本臨床外科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃癌骨転移例に関する臨床病理学的特徴と集学的治療

    • Author(s)
      肥田圭介ほか
    • Organizer
      第51回日本癌治療学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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