Novel mechanism and molecular targeted therapy of thyroid cancer

• Project/Area Number: 24591919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Chubu University
• Principal Investigator: TAKEDA Kozue 中部大学, 生命健康科学部, 准教授 (80345884)
• Co-Investigator(Kenkyū-buntansha): KAWAMOTO Yoshiyuki 中部大学, 生命健康科学部, 准教授 (10410664)
• Co-Investigator(Renkei-kenkyūsha): KATO Masashi 名古屋大学, 医学系研究科, 教授 (10281073)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: チロシンキナーゼ / RET / がん

Outline of Final Research Achievements

We previously demonstrated that a specific cysteine residue is crucially involved in regulation of RET kinase activity. In this study, we successfully inhibited the oncogenic RET kinase activity through the cysteine mediated novel regulation mechanisms and suppressed the malignancy of RET expressed tumor cells.

Research Products

• [Journal Article] Commentary to Pastore et al (2014): Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors (2014)
  • Author(s): K. Takeda, Y. Kawamoto, M. Iida, Y. Omata, C. Zou, M. Kato
  • Journal Title: Arch Toxicol Volume: 88 Issue: 12 Pages: 2319-2320
  • DOI: 10.1007/s00204-014-1373-9
  • Peer Reviewed
• [Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice. (2014)
  • Author(s): Iida M,Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M.
  • Journal Title: Eur J Dermatol Volume: 24 Issue: 3 Pages: 392-394
  • DOI: 10.1684/ejd.2014.2330
  • Peer Reviewed / Open Access
• [Journal Article] Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma. (2014)
  • Author(s): Omata Y, Iida M, Yajima I, Takeda K, Ohgami N, Masaru Hori H, Kato M.
  • Journal Title: Environ Health Prev Med. Volume: 19 Issue: 5 Pages: 367-369
  • DOI: 10.1007/s12199-014-0399-1
  • NAID: 50009312844
  • Peer Reviewed / Acknowledgement Compliant