Phosphatome - targeted therapy for breast cancer

• Project/Area Number: 24591928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: KAKUGAWA YOICHIRO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (60221173)
• Co-Investigator(Kenkyū-buntansha): FUKAMACHI Kayoko 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (00626137) ; SHIMA Hiroshi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 (10196462) ; NISHINO Yoshikazu 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん疫学・予防研究部, 部長 (70302099)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 乳がん / HER2 / ホスファターゼ / PP6 / ノックアウトマウス / BRCA1 / SNPs / HER２ / PP６ / BRCA１ / SNP

Outline of Final Research Achievements

BRCA1 gene is identified as one of anti-cancer gene against breast cancer. The function of BRCA1 is regulated by its status of phosphorylation, and PP6 is thought to be involved in this regulation. In this experiment, we firstly showed that PP6 functions as anti-oncogene in vivo.

Research Products

• [Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA (2015)
  • Author(s): Hayashi K, Momoi Y , Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, and Shima H
  • Journal Title: Oncogene Volume: 印刷中 Issue: 35 Pages: 4647-55
  • DOI: 10.1038/onc.2014.398
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cigarette smoking and breast cancer risk in relation to joint estrogen and progesterone receptor status: a case-control study in Japan (2014)
  • Author(s): Yoshikazu Nishino, Yuko Minami, Masaaki Kawai, Kayoko Fukamachi, Ikuro Sato, Noriaki Ohuchi, Yoichiro Kakugawa
  • Journal Title: Springerplus Volume: 3;65 Issue: 1 Pages: 1-15
  • DOI: 10.1186/2193-1801-3-65
  • Peer Reviewed
• [Journal Article] Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. (2014)
  • Author(s): Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K.
  • Journal Title: Nat Commun Volume: in press Issue: 1 Pages: 3393-3393
  • DOI: 10.1038/ncomms4393
  • Peer Reviewed / Open Access
• [Journal Article] Anthropometric factors, physical activity, and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women: a case-control study (2013)
  • Author(s): Masaaki Kawai, Yoichiro Kakugawa, Yoshikazu Nishino, Yohei Hamanaka, Noriaki Ohuchi, Yuko Minami
  • Journal Title: Cancer Causes Control Volume: 24 Issue: 5 Pages: 1033-1044
  • DOI: 10.1007/s10552-013-0181-5
  • Peer Reviewed
• [Journal Article] p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells. (2013)
  • Author(s): Notsuda H, Sakurada A, Endo C, Okada Y, Horii A, Shima H, Kondo T.
  • Journal Title: Int J Oncol Volume: 43 Issue: 5 Pages: 1569-1577
  • DOI: 10.3892/ijo.2013.2096
  • Peer Reviewed
• [Journal Article] Cigarette smoking and lung cancer risk according to histological type in Japanese men and women. (2013)
  • Author(s): Seki T, Takahashi S, et al.
  • Journal Title: Cancer Sci Volume: 104 Issue: 11 Pages: 1515-1522
  • DOI: 10.1111/cas.12273
  • Peer Reviewed
• [Journal Article] Being breastfed in infancy and adult breast cancer risk among Japasese women (2012)
  • Author(s): Minami Y
  • Journal Title: Cancer Causes Control Volume: 23 Pages: 389-398
  • Peer Reviewed
• [Journal Article] Reproductive factors and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women (2012)
  • Author(s): Kawai M
  • Journal Title: Cancer Sci. Volume: 103 Pages: 1861-1870
  • Peer Reviewed
• [Journal Article] Body mass index and survival after breast cancer diagnosis in Japanese women (2012)
  • Author(s): Kawai M
  • Journal Title: BMC Cancer Volume: 12 Pages: 148-149
  • Peer Reviewed
• [Journal Article] Novel function of MKP-5/DUSP10, a phosphatae of stres-activated inases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas (2012)
  • Author(s): Nomura M
  • Journal Title: Oncol Rep. Volume: 28 Pages: 931-936
  • Peer Reviewed
• [Presentation] Developing prognostic biomarker of breast cancer using expression profile about TP53 status. (2012)
  • Author(s): 高橋 信
  • Organizer: 第10回日本臨床腫瘍学会
  • Place of Presentation: 大阪
• [Presentation] 内分泌受容体別Reproductive factor と乳がん罹患リスクの症例対照研究 (2012)
  • Author(s): 河合 賢朗
  • Organizer: 第20回日本乳癌学会総会
  • Place of Presentation: 熊本
• [Presentation] やせ、肥満と乳がんの予後との関連 (2012)
  • Author(s): 角川 陽一郎
  • Organizer: 第２０回日本乳癌学会総会
  • Place of Presentation: 熊本
• [Presentation] 疫学的にみた乳がんハイリスクグループ (2012)
  • Author(s): 河合 賢朗
  • Organizer: 第22回日本乳癌検診学会
  • Place of Presentation: 沖縄
• [Presentation] Anthropometic factors, physical activity and breast cancer risk by hormone receptor status:a case control study (2012)
  • Author(s): Kawai M
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Book] がん化学療法とケアQ＆A 第2版 (2012)
  • Author(s): 角川 陽一郎
  • Total Pages: 2
  • Publisher: 総合医学社