Fundamental analyses of our near-infrared fluorescent liposome system as therapeutic agents against gastrointestinal malignancies
| Project/Area Number |
24591933
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
HAYASHI Hideki 千葉大学, フロンティア医工学センター, 教授 (20312960)
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| Co-Investigator(Renkei-kenkyūsha) |
TOYOTA Taro 東京大学, 総合文化研究科, 准教授 (80422377)
TAMURA Yutaka 千葉大学, 大学院医学研究院, 准教授 (50263174)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | インドシアニングリーン / 光線温熱療法 / 光線力学療法 / ハプテン |
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| Outline of Final Research Achievements |
We tested the basic effectiveness of our near-infrared fluorescent (NIRF) liposome system with newly-made hydrophobic form of Indocyanine green (ICG-C18) in gastrointestinal cancer therapy using tumor bearing mouse model. When NIRF liposomes of 200nm in mean diameter were administered to mice inoculated with esophageal carcinoma cell line, the liposomes were revealed to accumulate in the tumor with EPR effect. NIR light irradiation to the tumor after administration of the liposomes showed significant suppression of the tumor growth. Administration of the liposomes containing cisplatin indicated enhanced tumor growth suppression. In vitro analysis of the liposomes containing Dinitrophenol revealed that 1.5 to 4 % of the contents were released after irradiation of NIR light.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Treatment of near-infrared photodynamic therapy using a liposomally formulated indocyanine green derivative for squamous cell carcinoma2015
Author(s)
Maruyama T, Akutsu Y, Suganami A, Tamura Y, Fujito H, Ouchi T, Akanuma N, Isozaki Y, Takeshita N, Hoshino I, Uesato M, Toyota T, Hayashi H, Matsubara H
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Journal Title
PLoS One
Volume: 10
Issue: 4
Pages: e0122849-e0122849
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Detection of Peritoneal Dissemination with Near-infrared Fluorescence Laparoscopic Imaging Using a Liposomal Formulation of a Synthesized Indocyanine Green Liposomal Derivative2015
Author(s)
Hoshino I, Maruyama T, Fujito H, Tamura Y, Suganami A, Hayashi H, Toyota T, Akutsu Y, Murakami K, Isozaki Y, Akanuma N, Takeshita N, Toyozumi T, Komatsu A, Matsubara H
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Journal Title
Anticancer research
Volume: 35
Pages: 1353-1359
Related Report
Peer Reviewed
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[Journal Article] Near-infrared-fluorescence imaging of lymph nodes by using liposomally formulated indocyanine green derivatives2014
Author(s)
Taro Toyota, Hiromichi Fujito, Akiko Suganami, Tomoki Ouchi, Aki Ooishi, Akira Aoki, Kazutaka Onoue, Yutaka Muraki, Tomoyuki Madono, Masanori Fujinami, Yutaka Tamura, Hideki Hayashi
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Journal Title
Bioorganic & Medical Chemistry
Volume: 22
Issue: 2
Pages: 721-727
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of a non-blurring, dual-imaging tissue marker for gastrointestinal tumor localization2014
Author(s)
Hayashi, H., Toyota, T., Goto, S., Ooishi, A., Gao, T., Ee, L. B., Hatayama, H., Nomoto, T., Fujinami, M, Matsubara, H
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Journal Title
Surg Endosc
Volume: -
Issue: 6
Pages: 1445-1451
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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