Development of the anti-HER3 antibody therapy for esophageal squamous cell carcinoma.

• Project/Area Number: 24591936
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Yamanashi
• Principal Investigator: KAWAGUCHI Yoshihiko 山梨大学, 総合研究部, 助教 (80402048)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 食道扁平上皮癌 / 抗体療法 / HER3 / HER2 / 抗HER3抗体

Outline of Final Research Achievements

Relations on expressions among HER family (HER1, HER2, HER3) and antitumor effect of anti-HER3 antibody against different HER3-expressed cell clones of esophageal squamous cell carcinoma were investigated. We found HER3 expressions did not correlated with powers of antiproliferative activity, ADCC or proapototic activity induced by anti-HER3 antibody in any cell clones. In addition, correlation between HER1/HER2 and HER3 expressions was not found.

Research Products

• [Journal Article] Increased prevalence of tumor-infiltrating regulatory T cells is closely related to their lower sensitivity to H2O2-induced apoptosis in gastric and esophageal cancer. (2013)
  • Author(s): Izawa S
  • Journal Title: Cancer Immunol Immunother Volume: 62(1) Issue: 1 Pages: 161-70
  • DOI: 10.1007/s00262-012-1327-0
  • Peer Reviewed
• [Journal Article] Lapatinib acts on gastric cancer through both antiproliferative function and augmentation of trastuzumab-mediated antibody-dependent cellular cytotoxicity. (2012)
  • Author(s): Shiraishi K
  • Journal Title: Gastric Cancer Volume: Epub ahead of print Issue: 4 Pages: 571-80
  • DOI: 10.1007/s10120-012-0219-5
  • Peer Reviewed
• [Journal Article] Expression of MHC class I on breast cancer cells correlates inversely with HER2 expression. (2012)
  • Author(s): Inoue M
  • Journal Title: Oncoimmunology Volume: 1（7） Issue: 7 Pages: 1104-10
  • DOI: 10.4161/onci.21056
  • Peer Reviewed
• [Presentation] 胃癌・食道癌微小環境におけるRective Oxygen Speciesとregulatory T cell(T-reg)の関係 (2012)
  • Author(s): 井澤伸一郎
  • Organizer: 第33回癌免疫外科研究会
  • Place of Presentation: 新横浜プリンスホテル（神奈川県）
• [Presentation] 胃癌におけるHER2を標的とした分子標的治療の可能性について (2012)
  • Author(s): 白石謙介
  • Organizer: 第33回癌免疫外科研究会
  • Place of Presentation: 新横浜プリンスホテル（神奈川県）
• [Presentation] 乳癌におけるHER2発現と癌抗原特異的T細胞の効果について (2012)
  • Author(s): 丸山孝教
  • Organizer: 第20回日本乳癌学会学術総会
  • Place of Presentation: 熊本市民会館（熊本県）
• [Presentation] 胃癌におけるHER2を標的とした分子標的治療の可能性について (2012)
  • Author(s): 白石謙介
  • Organizer: JDDW2012
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Remarks] 山梨大学研究者総覧
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.List/3_70.html