The role of cancer-related exosome on chemoresistance in esophageal cancer

Research Project

Project/Area Number	24591942
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2014) Osaka University (2012-2013)
Principal Investigator	MIYATA Hiroshi 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他 (80362713)
Co-Investigator(Kenkyū-buntansha)	SUGIMURA Keijiro 大阪府立成人病センター, 消化器外科, 医長 (00571374) YAMASAKI Makoto 大阪大学, 大学院消化器外科, 助教 (50444518) TAKAHASHI Tsuyoshi 大阪大学, 大学院消化器外科, 助教 (50452389) TANAKA Koji 大阪大学, 医学部附属病院 (70621019)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	エクソソーム / マイクロRNA / 食道癌 / 化学療法 / 腫瘍間質 / 化学り療法
Outline of Final Research Achievements	Our results suggested that miR-27 is involved in resistance to chemotherapy in esophageal cancer, through miR-27 -induced transformation of normal fibroblast into cancer-associated fibroblasts(CAFs), and that TGF-β　secreted from these CAF-like fibroblasts induces chemoresistance to cisplatin in esophageal cancer. Based on these results, we believe that miR-27 , which can be secreted from esophageal cancer with being contained in exosome, is a potential therapeutic target for esophageal cancer treated with anticancer drugs.