| Project/Area Number |
24591942
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2014)
Osaka University (2012-2013) |
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Principal Investigator |
MIYATA Hiroshi 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他 (80362713)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMURA Keijiro 大阪府立成人病センター, 消化器外科, 医長 (00571374)
YAMASAKI Makoto 大阪大学, 大学院消化器外科, 助教 (50444518)
TAKAHASHI Tsuyoshi 大阪大学, 大学院消化器外科, 助教 (50452389)
TANAKA Koji 大阪大学, 医学部附属病院 (70621019)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | エクソソーム / マイクロRNA / 食道癌 / 化学療法 / 腫瘍間質 / 化学り療法 |
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| Outline of Final Research Achievements |
Our results suggested that miR-27 is involved in resistance to chemotherapy in esophageal cancer, through miR-27 -induced transformation of normal fibroblast into cancer-associated fibroblasts(CAFs), and that TGF-β secreted from these CAF-like fibroblasts induces chemoresistance to cisplatin in esophageal cancer. Based on these results, we believe that miR-27 , which can be secreted from esophageal cancer with being contained in exosome, is a potential therapeutic target for esophageal cancer treated with anticancer drugs.
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