The study of novel prognostic marker and therapeutic target in esophageal squamous cell carcinoma patients

• Project/Area Number: 24591954
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: OKUMURA Hiroshi 鹿児島大学, 医学部・歯学部附属病院, 講師 (10398282)
• Co-Investigator(Kenkyū-buntansha): ISHIGAMI Sumiya 鹿児島大学, 医歯学総合研究科, 准教授 (90325803) ; NATSUGOE Shoji 鹿児島大学, 医歯学総合研究科, 教授 (70237577) ; UCHIKADO Yasuto 鹿児島大学, 医学部・歯学部附属病院, 特例准教授 (30464465) ; 佐々木 健 鹿児島大学, 医学部・歯学部附属病院, その他 (00418849) ; 喜多 芳昭 鹿児島大学, 医学部・歯学部附属病院, その他 (30570692)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 食道癌 / 癌遺伝子 / 予後因子 / 治療ターゲット / 食道癌治療 / 癌幹細胞 / 集学的治療

Outline of Final Research Achievements

CYHR1 (cysteine/histidine-rich1) was first discovered in a yeast two-hybrid screen with murine galectin-3, and there have been no previous reports of a relationship between the CYHR1 gene and human cancer. The present study evaluated the role and significance of CYHR1 in esophageal cancer. CYHR1 is associated with proliferation, invasion and tumorigenicity in esophageal cancer cells. The expression of CYHR1 mRNA is associated with lymph node metastasis and stage, and it is an independent prognostic factor in patients with esophageal cancer. CYHR1 is not only a prognostic marker for esophageal squamous cell carcinoma patients but also a possible therapeutic target.

Research Products

• [Journal Article] Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer (2015)
  • Author(s): Kawasaki Y, Ishigami S, Arigami T, Uenosono Y, Yanagita S, Uchikado Y, Kita Y, Nishizono Y, Okumura H, Nakajo A, Kijima Y, Maemura K, Natsugoe S.
  • Journal Title: BMC Cancer Volume: 15 Issue: 1 Pages: 5-5
  • DOI: 10.1186/s12885-015-1008-4
  • Peer Reviewed / Open Access
• [Journal Article] Nrf2 is useful for predicting the effect of chemoradiation therapy on esophageal squamous cell carcinoma (2014)
  • Author(s): Kawasaki Y, Okumura H, Uchikado Y, Kita Y, Sasaki K, Owaki T, Ishigami S, Natsugoe S
  • Journal Title: Ann Surg Oncol Volume: 21 Issue: 7 Pages: 2347-2352
  • DOI: 10.1245/s10434-014-3600-2
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical and biological impact of cyclin-dependent kinase subunit 2 in esophageal squamous cell carcinoma (2014)
  • Author(s): Kita Y, Nishizono Y, Okumura H, Uchikado Y, Sasaki K, Matsumoto M, Setoyama T, Tanoue K, Omoto I, Mori S, Owaki T, Ishigami S, Nakagawa H, Tanaka F, Mimori K, Mori M, Natsugoe S
  • Journal Title: Oncol Rep Volume: 31 Issue: 5 Pages: 1986-1992
  • DOI: 10.3892/or.2014.3062
  • Peer Reviewed
• [Journal Article] Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma (2014)
  • Author(s): Omoto I, Matsumoto M, Okumura H, Uchikado Y, Setoyama T, Kita Y, Owaki T, Kijima Y, Shinchi H, Ishigami S, Ueno S, Natsugoe S
  • Journal Title: Oncol Lett Volume: 7 Pages: 1027-1032
  • Peer Reviewed
• [Journal Article] Immunohistochemical evidence of association between ghrelin expression and tumor growth in esophageal Carcinoma (2014)
  • Author(s): Omoto I, Matsumoto M, Uchikado Y, Kita Y, Sakurai T, Sasaki K, Setoyama T, Okumura H, Owaki T, Ishigami S, Natsugoe S
  • Journal Title: Anticancer Res Volume: 34 Pages: 2727-2733
  • Peer Reviewed
• [Journal Article] The usefulness of neoadjuvant chemoradiation therapy for locally advanced esophageal cancer with multiple lymph-node metastases (2014)
  • Author(s): Okumura H, Uchikado Y, Omoto I, Kita Y, Sasaki K, Arigami T, Uenosono Y, Matsushita D, Hiraki Y, Owaki T, Ishigami S, Natsugoe S:
  • Journal Title: Ann Surg Oncol Volume: 21 Issue: 9 Pages: 2845-9
  • DOI: 10.1245/s10434-014-3688-4
  • Peer Reviewed
• [Journal Article] Decreased density of CD3+ tumor-infiltrating lymphocytes during gastric cancer progression (2014)
  • Author(s): Arigami T, Uenosono Y, Ishigami S, Matsushita D, Hirahara T, Yanagita S, Okumura H, Uchikado Y, Nakajo A, Kijima Y, Natsugoe S
  • Journal Title: J Gastroenterol Hepatol Volume: 29 Pages: 1435-41
  • Peer Reviewed
• [Journal Article] Endoglin (CD105) is a useful marker for evaluating microvessel density and predicting the prognosis in esophageal squamous cell carcinoma (2014)
  • Author(s): Sakurai T, Okumura H, Matsumoto M, Uchikado Y, Owaki T, Kita Y, Setoyama T, Omoto I, Kijima Y, Ishigami S, Natsugoe S
  • Journal Title: Anticancer Res Volume: 34 Pages: 3431-8
  • Peer Reviewed
• [Journal Article] Biomarkers for predicting the response of esophageal squamous cell carcinoma to neoadjuvant chemoradiation therapy (2014)
  • Author(s): Okumura H, Uchikado Y, Setoyama T, Matsumoto M, Owaki T, Ishigami S, Natsugoe S
  • Journal Title: Surg Today Volume: 44 Issue: 3 Pages: 421-428
  • DOI: 10.1007/s00595-013-0580-y
  • Peer Reviewed
• [Journal Article] Nrf2 is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma (2014)
  • Author(s): Kawasaki Y, Okumura H, Uchikado Y, Kita Y, Sasaki K, Owaki T, Ishigami S, Natsugoe S
  • Journal Title: Ann Surg Oncol Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy (2013)
  • Author(s): Okumura H, Uchikado Y, Matsumoto M, Owaki T, Kita Y, Omoto I, Sasaki K, Sakurai T, Setoyama T, Nabeki B, Matsushita D, Ishigami S, Hiraki Y, Nakajo M, Natsugoe S
  • Journal Title: Int J Clin Oncol Volume: 18 Issue: 2 Pages: 329-334
  • DOI: 10.1007/s10147-012-0383-y
  • NAID: 10031176273
  • Peer Reviewed
• [Journal Article] The expression of LC-3 is related to tumor suppression through angiogenesis in esophageal cancer (2013)
  • Author(s): Sakurai T, Okumura H, Matsumoto M, Uchikado Y, Setoyama T, Omoto I, Owaki T, Maemura K, Ishigami S, Natsugoe S
  • Journal Title: Med Oncol Volume: 30 Issue: 4 Pages: 701-708
  • DOI: 10.1007/s12032-013-0701-x
  • Peer Reviewed
• [Journal Article] Clinical Significance of (18)F-fluorodeoxyglucose Positron Emission Tomography in Superficial Esophageal Squamous Cell Carcinoma. (2013)
  • Author(s): Kita Y, Ueno S, et al.
  • Journal Title: Ann Surg Oncol. Volume: 20 Issue: 5 Pages: 1646-1652
  • DOI: 10.1245/s10434-012-2796-2
  • NAID: 120005447077
  • Peer Reviewed
• [Journal Article] Serumconcentrations of antibiotics during severe invasive surgery such asesophagectomy for esophageal cancer (2013)
  • Author(s): Owaki T, Okumura H, Uchikado Y, Sasaki K, Matsumoto M, Omoto I, Setoyama T,Kita Y, Sakurai T, Matsushita D, Ishigami S, Ueno S, Natsugoe S
  • Journal Title: Int Surg Volume: 98 Issue: 1 Pages: 1-5
  • DOI: 10.9738/cc164.1
  • Peer Reviewed
• [Presentation] Ferredoxin Reductase (Fdxr）発現と化学（放射線）療法感受性 (2014)
  • Author(s): 奥村浩, 内門泰斗,尾本至, 肥後直倫, 出先亮介, 野田昌宏, 喜多芳昭, 佐々木健, 瀬戸山徹郎, 惠浩一, 有上貴明, 上之園芳一, 盛真一郎, 馬場研二, 大脇哲洋, 石神純也, 夏越祥次
  • Organizer: 第25回日本消化器癌発生学会総会
  • Place of Presentation: 福岡（アクロス福岡）
  • Year and Date: 2014-11-24
• [Presentation] 多発リンパ節転移を伴う食道癌に対する術前化学放射線療法 (2014)
  • Author(s): 奥村浩, 内門泰斗, 尾本至, 喜多芳昭, 佐々木健, 上之園芳一, 有上貴明, 大脇哲洋, 盛真一郎, 石神純也, 夏越祥次
  • Organizer: 第76回日本臨床外科学会総会シンポジウム
  • Place of Presentation: 福島（郡山市民文化センター）
  • Year and Date: 2014-11-21
• [Presentation] 多発リンパ節転移を伴う食道癌に対する術前化学放射線療法の意義 (2014)
  • Author(s): 奥村浩, 内門泰斗, 尾本至, 喜多芳昭, 佐々木健, 上之園芳一, 有上貴明, 大脇哲洋, 石神純也, 上野真一, 夏越祥次
  • Organizer: 第22回日本消化器関連学会週間(JDDW)
  • Place of Presentation: 神戸（神戸国際展示場）
  • Year and Date: 2014-10-24
• [Presentation] 第52回日本癌治療学会, 多発リンパ節転移を伴う食道癌に対する術前化学放射線療法の意義 (2014)
  • Author(s): 奥村浩, 内門泰斗, 尾本至, 喜多芳昭, 佐々木健, 上之園芳一, 有上貴明, 大脇哲洋, 上野真一, 石神純也, 夏越祥次
  • Organizer: 第52回日本癌治療学会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2014-08-28
• [Presentation] 食道胃接合部癌に対する治療戦略 (2014)
  • Author(s): 奥村浩, 石神純也, 大脇哲洋, 内門泰斗, 尾本至, 喜多芳昭, 佐々木健,
  • Organizer: 第69回日本消化器外科学会総会
  • Place of Presentation: 福島（郡山市民文化センター）
  • Year and Date: 2014-07-17
• [Presentation] 食道癌細胞の活性酸素産生能による食道癌術前化学放射線療の効果予測法 (2014)
  • Author(s): 奥村浩, 川崎洋太, 内門泰斗, 尾本至, 大脇哲洋, 喜多芳昭, 佐々木健, 石神純也, 夏越祥次
  • Organizer: 第68回日本食道学会学術集会
  • Place of Presentation: 東京（東京ドーム）
  • Year and Date: 2014-07-03
• [Presentation] 局所進行食道癌における術前化学放射線療法 (2014)
  • Author(s): 奥村浩, 松本正隆, 内門泰斗, 大脇哲洋, 喜多芳昭, 尾本至, 佐々木健, 松下大輔, 石神純也, 夏越祥次
  • Organizer: 第114回日本外科学会学術集会
  • Place of Presentation: 京都（国立京都国際会館）
  • Year and Date: 2014-04-05
• [Presentation] Prognostic Factor in Esophageal Squamous cell carcinoma Patients Treated with Neoadjuvant Chemoradiation Therapy and Determination of an Appropriate Strategy for Their Evaluation (2012)
  • Author(s): Okumura H, Uchikado Y, Matsumoto M, Owaki T, Kita Y, Omoto I, Sasaki K, Sakurai T, Setoyama T, Nabeki B, Matsushita D, Ishigami S, Suenaga T, Natsugoe S
  • Organizer: 13th World Congress of the International Society for Disease of the Esophagus
  • Place of Presentation: Venice Italy
• [Presentation] 食道癌術前化学放射線療法症例の検討 (2012)
  • Author(s): 奥村浩，夏越祥次，松本正隆，内門泰斗，大脇哲洋，喜多芳昭，尾本至，佐々木健，石神純也，上野真一、夏越祥次
  • Organizer: 第67回日本消化器外科学会定期総会
  • Place of Presentation: 富山市
• [Presentation] Neoadjuvant chemoradiation therapy for advanced esophageal cancer patients
  • Author(s): Hiroshi Okumura， Yasuto Uchikado， Tetsuhiro Owaki， Masataka Matsumoto， Yoshiaki Kita， Tetsuro Setoyama， Itaru Omoto， Ken Sasaki， Sumiya Ishigami， Sinichi Ueno， Shoji Natsugoe
  • Organizer: The 113th Annual Congress of Japan Surgical Society， Symposium
  • Place of Presentation: Fukuoka Japan
• [Presentation] 局所進行食道癌に対する治療戦略 ―リンパ節転移制御を目的とした術前化学放射線治療の意義―
  • Author(s): 奥村 浩，内門泰斗，佐々木 健，喜多芳昭，松本正隆，尾本 至，石神純也， 大脇哲洋，上野真一， 夏越祥次
  • Organizer: 第68回日本消化器外科学会定期総会，シンポジウム
  • Place of Presentation: 宮崎市
• [Presentation] 進行食道癌に対する術前化学放射線治療法の治療成績と今後の展望
  • Author(s): 奥村 浩，内門泰斗，大脇哲洋，松本正隆，喜多芳昭，瀬戸山徹郎， 尾本 至，佐々木 健，石神純也，上野真一，夏越祥次
  • Organizer: 第67回日本食道学会定期学術集会
  • Place of Presentation: 大阪市
• [Presentation] 癌抑制遺伝子FhitノックアウトマウスおよびFhit/Nit1ダブルノックアウトマウスにおける消化管腫瘍の解析
  • Author(s): 奥村 浩，内門泰斗，佐々木 健， 喜多芳昭， 大脇哲洋， 有上貴明， 上之園芳一， 石神純也，夏越祥次
  • Organizer: 第24回日本消化器癌発生学会総会ワークショップ
  • Place of Presentation: 金沢市
• [Presentation] The usefulness of estimating pN status and T-effect of ESCC patients treated with neoadjuvant CRT
  • Author(s): Hiroshi Okumura， Yasuto Uchikado， Masataka Matsumoto， Tetsuhiro Owaki， Yoshiaki Kita， Itaru Omoto， Ken Sasaki， Yoshikazu Uenosono， Sumiya Ishigami， Shoji Natsugoe
  • Organizer: 1st International Conference of Federation of Asian Clinical Oncology (FACO)
  • Place of Presentation: Xiamen， China
• [Presentation] 食道癌術前化学放射線療法の効果予測バイオマーカーの検討
  • Author(s): 奥村 浩，内門泰斗，川崎洋太，喜多芳昭，尾本 至， 佐々木 健，大脇哲洋，石神純也，有上貴明， 上之園芳一， 盛 真一郎， 上野真一，夏越祥次
  • Organizer: 第51回癌治療学会学術集会
  • Place of Presentation: 京都市