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Exploration of biological charactoristics of residual cancer after chemotherapy

Research Project

Project/Area Number 24591955
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

ISHIGAMI SUMIYA  鹿児島大学, 医歯(薬)学総合研究科, 准教授 (90325803)

Co-Investigator(Kenkyū-buntansha) MAEMURA Kousei  鹿児島大学, 医歯学総合研究科, 特任准教授 (30398292)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords化学療法 / 消化器癌 / 遺残 / キャラクター
Outline of Final Research Achievements

We tried to investigate analysis of characteristics of residual cancer after the chemotherapy especially in gastrointestinal cancer.We previously demostrated the clinical significance of CD133 expression in gastric cancer including an independent prognostic factor. However, immunohistochemically, CD133 expression of the residual cancer after the chemotherapy could not reflect aggressiveness of tumor behavior in gastric cancer. We now tried to clarify the clinical significance of MIB-1, Fox3p positive cells, PDL1 expression in the cancer stroma after the chemotherapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2015 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 1 results) Presentation (10 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Human Leukocyte Antigen (HLA)-E and HLA-F Expression in Gastric Cancer2015

    • Author(s)
      Ishigami S
    • Journal Title

      Anticancer RES

      Volume: 35 Pages: 2279-85

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-32 Expression and Treg Infiltration in Esophageal Squamous Cell Carcinoma2015

    • Author(s)
      Nabeki B
    • Journal Title

      Anticancer RES

      Volume: 35 Pages: 1111-1111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical utility of perioperative staging laparoscopy for advanced gastric cancer.2014

    • Author(s)
      Ishigami S
    • Journal Title

      World J Surg Oncol

      Volume: 18 Issue: 1 Pages: 350-350

    • DOI

      10.1186/1477-7819-12-350

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical implications of DLL4 expression in gastric cancer.2013

    • Author(s)
      Ishigami S, Ueno S, et al.
    • Journal Title

      J Exp Clin Cancer Res.

      Volume: 32 Issue: 1 Pages: 46-46

    • DOI

      10.1186/1756-9966-32-46

    • NAID

      120005367610

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of sudden onset septicemia in recurred gastric cancer following s1 plus docetaxel treatment2013

    • Author(s)
      Ishigami S
    • Journal Title

      J Gastric Cancer

      Volume: 13 Issue: 2 Pages: 126-8

    • DOI

      10.5230/jgc.2013.13.2.126

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical-pathological implication of human leukocyte antigen-F-positive gastric adenocarcinoma2013

    • Author(s)
      Ishigami S
    • Journal Title

      J Surg Res

      Volume: 184 Issue: 2 Pages: 802-6

    • DOI

      10.1016/j.jss.2013.04.003

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-32 expression is an independent prognostic marker for gastric cancer.2013

    • Author(s)
      Ishigami S, Ueno S, et al.
    • Journal Title

      Med Oncol.

      Volume: 30 Issue: 2 Pages: 472-472

    • DOI

      10.1007/s12032-013-0472-4

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 進行・再発胃癌に対する化学放射線療法の治療成績2013

    • Author(s)
      石神 純也
    • Journal Title

      癌と化学療法

      Volume: 40 Pages: 1213-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical implication of HLA-F in gasgtric cancer2013

    • Author(s)
      Ishigami s
    • Journal Title

      J Surg Res

      Volume: 23 Pages: 414-414

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cancerous HLA class I expression and regulatory T cell infiltration in gastric cancer.2012

    • Author(s)
      Ishigami s
    • Journal Title

      Cancer Immunol Immunother

      Volume: 61 Pages: 1663-9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of advanced gastric adenocarcinoma with portal tumor thrombosis by total gastrectomy following2012

    • Author(s)
      Ishigami s
    • Journal Title

      Clin J Gastroenterol

      Volume: 5 Pages: 230-233

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Stage IV胃癌におけるConversion therapyの可能性2014

    • Author(s)
      石神純也
    • Organizer
      日本臨床外科学会
    • Place of Presentation
      郡山市(郡山市民文化センター)
    • Year and Date
      2014-11-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃全摘後のY脚パウチ法2014

    • Author(s)
      石神純也
    • Organizer
      第44回胃外科・術後障害研究会
    • Place of Presentation
      富士市(ロゼシアター)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高度進行再発胃癌に対する化学放射線療法の有用性について2014

    • Author(s)
      石神純也
    • Organizer
      第52回日本癌治療学会
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃癌におけるHLA-E およびHLA-F発現と臨床的意義2014

    • Author(s)
      石神純也
    • Organizer
      第35回癌免疫外科研究会
    • Place of Presentation
      大阪市(シャトラン都ホテル大阪)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃癌および食道癌における腫瘍IL32の発現と臨床病理学的意義2012

    • Author(s)
      石神純也、辺木文平、青木雅也、恵浩一、内門泰斗、有上貴明、喜多芳昭、上之園芳一、奥村浩、上野真一、夏越祥次
    • Organizer
      第21回がん転移学会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行・再発胃癌に対する治療戦略 -外科治療の介入時期について-シンポジウム32012

    • Author(s)
      石神純也、有上貴明、上之園芳一、内門泰斗、奥村浩、佐々木健、喜多芳昭、大脇哲洋、上野真一、帆北修一、夏越祥次
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report
  • [Presentation] 切除困難胃癌化学療法後の手術 根治切除はどこまで可能か2012

    • Author(s)
      石神純也、有上貴明、上之園芳一、内門泰斗、奥村浩、佐々木健、喜多芳昭、大脇哲洋、上野真一、帆北修一、夏越祥次
    • Organizer
      第112回日本外科学会総会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行胃癌外科治療における術中腹腔鏡検査の活用2012

    • Author(s)
      石神純也、有上貴明、上之園芳一、内門泰斗、奥村浩、佐々木健、喜多芳昭、大脇哲洋、上野真一、帆北修一、夏越祥次
    • Organizer
      第74回日本臨床外科学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行胃癌に対する放射線化学療法の治療成績について

    • Author(s)
      石神純也
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinical implication of salvage surgery following chemotherapy for stage IV gastric cancer

    • Author(s)
      Sumiya Ishigami
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
  • [Book] 開腹幽門側胃切除術(早期・進行胃癌) 胃外科のすべて2014

    • Author(s)
      石神純也
    • Publisher
      medical view
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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