| Project/Area Number |
24591959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Mitsuo 埼玉医科大学, 医学部, 教授 (20200165)
KOYAMA Isamu 埼玉医科大学, 医学部, 教授 (60178390)
OKADA Katsuya 埼玉医科大学, 医学部, 助教 (60364775)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 食道再生 / 食道狭窄 / 生体吸収性材料 / 組織再生 / 食道外科 / 食道縫合不全 / 食道皮膚瘻 / 生体吸収性素材 / 消化器外科 / 縫合不全 / 生体吸収性ステント / 消化管ステント |
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| Outline of Final Research Achievements |
Esophageal injury was complicated situation and requires much invasive methods for the treatment in long term. In this study, we replaced an artificial esophageal wall(AEW) made by bioabsorbable polymer(BAP) into an esophageal injury and we investigated the effectiveness of treatment using AEW in clinical use. The AEW was compatible to defected esophageal healing and could cure benign esophageal stricture. Biodegradable self-expandable covered stent made by BAP was effective to treat acute esophageal perforation in less invasive procedure. Our study used large animal models, so the study is easy to transfer to clinical usage and may treat various esophageal diseases.
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