| Project/Area Number |
24591962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAMOTO Haruhiko 近畿大学, 医学部, 教授 (80351609)
IMANO Motohiro 近畿大学, 医学部, 准教授 (00278681)
SHINKAI Masayuki 近畿大学, 医学部, 講師 (80340793)
YASUDA Atsushi 近畿大学, 医学部, 講師 (60351615)
SHIRAISHI Osamu 近畿大学, 医学部, 講師 (70388536)
IWAMA Mitsuru 近畿大学, 医学部, 講師 (20548648)
KATO Hiroaki 近畿大学, 医学部, 講師 (30460900)
塩崎 均 近畿大学, 医学部, 教授 (70144475)
錦 耕平 近畿大学, 医学部附属病院, 助教 (90441039)
曽我部 俊介 近畿大学, 医学部, 助教 (90580754)
田中 裕美子 近畿大学, 医学部附属病院, 助教 (90642877)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | p53-Ser-46 / 食道扁平上皮癌 / 治療効果予測 / リン酸化誘導 / バイオマーカー / アポトーシス / 食道癌 / p53 / 治療効果 / P53 Ser46 リン酸化 / 遺伝子変異 / p53-Ser46 / リン酸化 / 個別化治療 / apoptosis / P53 / Ser46 / 効果予測 / 個別化 |
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| Outline of Final Research Achievements |
In this study, we examined the usefulness of induction of the phosphorylation of p53-Ser46 the next day after initiation of treatment as a biomarker of the prediction of treatment response of chemotherapy/chemoradiotherapy for esophageal squamous cell carcinoma. We confirmed the fact for the first time that the phosphorylation of p53-Ser-46 was induced by chemotherapy/chemoradiotherapy in the early stage of treatment. However, there was no significant correlation between the phosphorylation of p-53-Ser-46 and treatment response. Among cases obtained complete response to preoperative therapy, the cases with p-53 mutant and no induction of Ser-46 phosphorylation were involved, therefore, these results suggested that the effect on chemotherapy and chemoradiotherapy was caused not only by apoptosis thorough p53 pathway, but also by another pathway associating with other factors.
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